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The Journal of Artificial Intelligence Research (JAIR) is dedicated to the rapid dissemination of important research results to the global artificial intelligence (AI) community. The journal’s scope encompasses all areas of AI, including agents and multi-agent systems, automated reasoning, constraint processing and search, knowledge representation, machine learning, natural language, planning and scheduling, robotics and vision, and uncertainty in AI.

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• Published: 24 February 2023

Artificial intelligence in academic writing: a paradigm-shifting technological advance

• Roei Golan   ORCID: orcid.org/0000-0002-7214-3073 1   na1 ,
• Rohit Reddy 2   na1 ,
• Akhil Muthigi 2 &
• Ranjith Ramasamy 2  

Nature Reviews Urology volume  20 ,  pages 327–328 ( 2023 ) Cite this article

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Artificial intelligence (AI) has rapidly become one of the most important and transformative technologies of our time, with applications in virtually every field and industry. Among these applications, academic writing is one of the areas that has experienced perhaps the most rapid development and uptake of AI-based tools and methodologies. We argue that use of AI-based tools for scientific writing should widely be adopted.

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Acknowledgements

The manuscript was edited for grammar and structure using the advanced language model ChatGPT. The authors thank S. Verma for addressing inquiries related to artificial intelligence.

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These authors contributed equally: Roei Golan, Rohit Reddy.

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Department of Clinical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA

Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA

Rohit Reddy, Akhil Muthigi & Ranjith Ramasamy

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Correspondence to Ranjith Ramasamy .

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R.R. is funded by the National Institutes of Health Grant R01 DK130991 and the Clinician Scientist Development Grant from the American Cancer Society. The other authors declare no competing interests.

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Golan, R., Reddy, R., Muthigi, A. et al. Artificial intelligence in academic writing: a paradigm-shifting technological advance. Nat Rev Urol 20 , 327–328 (2023). https://doi.org/10.1038/s41585-023-00746-x

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The present and future of AI

Finale doshi-velez on how ai is shaping our lives and how we can shape ai.

Finale Doshi-Velez, the John L. Loeb Professor of Engineering and Applied Sciences. (Photo courtesy of Eliza Grinnell/Harvard SEAS)

How has artificial intelligence changed and shaped our world over the last five years? How will AI continue to impact our lives in the coming years? Those were the questions addressed in the most recent report from the One Hundred Year Study on Artificial Intelligence (AI100), an ongoing project hosted at Stanford University, that will study the status of AI technology and its impacts on the world over the next 100 years.

The 2021 report is the second in a series that will be released every five years until 2116. Titled “Gathering Strength, Gathering Storms,” the report explores the various ways AI is  increasingly touching people’s lives in settings that range from  movie recommendations  and  voice assistants  to  autonomous driving  and  automated medical diagnoses .

Barbara Grosz , the Higgins Research Professor of Natural Sciences at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) is a member of the standing committee overseeing the AI100 project and Finale Doshi-Velez , Gordon McKay Professor of Computer Science, is part of the panel of interdisciplinary researchers who wrote this year’s report. 

We spoke with Doshi-Velez about the report, what it says about the role AI is currently playing in our lives, and how it will change in the future.  

Q: Let's start with a snapshot: What is the current state of AI and its potential?

Doshi-Velez: Some of the biggest changes in the last five years have been how well AIs now perform in large data regimes on specific types of tasks.  We've seen [DeepMind’s] AlphaZero become the best Go player entirely through self-play, and everyday uses of AI such as grammar checks and autocomplete, automatic personal photo organization and search, and speech recognition become commonplace for large numbers of people.  

In terms of potential, I'm most excited about AIs that might augment and assist people.  They can be used to drive insights in drug discovery, help with decision making such as identifying a menu of likely treatment options for patients, and provide basic assistance, such as lane keeping while driving or text-to-speech based on images from a phone for the visually impaired.  In many situations, people and AIs have complementary strengths. I think we're getting closer to unlocking the potential of people and AI teams.

There's a much greater recognition that we should not be waiting for AI tools to become mainstream before making sure they are ethical.

Q: Over the course of 100 years, these reports will tell the story of AI and its evolving role in society. Even though there have only been two reports, what's the story so far?

There's actually a lot of change even in five years.  The first report is fairly rosy.  For example, it mentions how algorithmic risk assessments may mitigate the human biases of judges.  The second has a much more mixed view.  I think this comes from the fact that as AI tools have come into the mainstream — both in higher stakes and everyday settings — we are appropriately much less willing to tolerate flaws, especially discriminatory ones. There's also been questions of information and disinformation control as people get their news, social media, and entertainment via searches and rankings personalized to them. So, there's a much greater recognition that we should not be waiting for AI tools to become mainstream before making sure they are ethical.

Q: What is the responsibility of institutes of higher education in preparing students and the next generation of computer scientists for the future of AI and its impact on society?

First, I'll say that the need to understand the basics of AI and data science starts much earlier than higher education!  Children are being exposed to AIs as soon as they click on videos on YouTube or browse photo albums. They need to understand aspects of AI such as how their actions affect future recommendations.

But for computer science students in college, I think a key thing that future engineers need to realize is when to demand input and how to talk across disciplinary boundaries to get at often difficult-to-quantify notions of safety, equity, fairness, etc.  I'm really excited that Harvard has the Embedded EthiCS program to provide some of this education.  Of course, this is an addition to standard good engineering practices like building robust models, validating them, and so forth, which is all a bit harder with AI.

I think a key thing that future engineers need to realize is when to demand input and how to talk across disciplinary boundaries to get at often difficult-to-quantify notions of safety, equity, fairness, etc. 

Q: Your work focuses on machine learning with applications to healthcare, which is also an area of focus of this report. What is the state of AI in healthcare? 

A lot of AI in healthcare has been on the business end, used for optimizing billing, scheduling surgeries, that sort of thing.  When it comes to AI for better patient care, which is what we usually think about, there are few legal, regulatory, and financial incentives to do so, and many disincentives. Still, there's been slow but steady integration of AI-based tools, often in the form of risk scoring and alert systems.

In the near future, two applications that I'm really excited about are triage in low-resource settings — having AIs do initial reads of pathology slides, for example, if there are not enough pathologists, or get an initial check of whether a mole looks suspicious — and ways in which AIs can help identify promising treatment options for discussion with a clinician team and patient.

Q: Any predictions for the next report?

I'll be keen to see where currently nascent AI regulation initiatives have gotten to. Accountability is such a difficult question in AI,  it's tricky to nurture both innovation and basic protections.  Perhaps the most important innovation will be in approaches for AI accountability.

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Title: promises and challenges of generative artificial intelligence for human learning.

Abstract: Generative artificial intelligence (GenAI) holds the potential to transform the delivery, cultivation, and evaluation of human learning. This Perspective examines the integration of GenAI as a tool for human learning, addressing its promises and challenges from a holistic viewpoint that integrates insights from learning sciences, educational technology, and human-computer interaction. GenAI promises to enhance learning experiences by scaling personalised support, diversifying learning materials, enabling timely feedback, and innovating assessment methods. However, it also presents critical issues such as model imperfections, ethical dilemmas, and the disruption of traditional assessments. Cultivating AI literacy and adaptive skills is imperative for facilitating informed engagement with GenAI technologies. Rigorous research across learning contexts is essential to evaluate GenAI's impact on human cognition, metacognition, and creativity. Humanity must learn with and about GenAI, ensuring it becomes a powerful ally in the pursuit of knowledge and innovation, rather than a crutch that undermines our intellectual abilities.

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Overview of Artificial General Intelligence (AGI)

• First Online: 31 August 2024

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• Oroos Arshi 11 &
• Aryan Chaudhary 12  

Part of the book series: Advanced Technologies and Societal Change ((ATSC))

Artificial General Intelligence (AGI) is the pinnacle of artificial intelligence, intending to imbue robots with the ability to comprehend, absorb, and apply information throughout a wide range of tasks with human-level competence. Unlike narrow or specialized AI, which concentrates on specific domain names, AGI attempts to emulate human beings’ diverse cognitive capacities. This introductory section attempts to lay the framework for a comprehensive analysis of AGI, encompassing its origins, previous development, and the enormous implications it holds for the future.

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Arshi, O., Chaudhary, A. (2025). Overview of Artificial General Intelligence (AGI). In: El Hajjami, S., Kaushik, K., Khan, I.U. (eds) Artificial General Intelligence (AGI) Security. Advanced Technologies and Societal Change. Springer, Singapore. https://doi.org/10.1007/978-981-97-3222-7_1

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The best AI tools for research papers and academic research (Literature review, grants, PDFs and more)

As our collective understanding and application of artificial intelligence (AI) continues to evolve, so too does the realm of academic research. Some people are scared by it while others are openly embracing the change. 

Make no mistake, AI is here to stay!

Instead of tirelessly scrolling through hundreds of PDFs, a powerful AI tool comes to your rescue, summarizing key information in your research papers. Instead of manually combing through citations and conducting literature reviews, an AI research assistant proficiently handles these tasks.

These aren’t futuristic dreams, but today’s reality. Welcome to the transformative world of AI-powered research tools!

This blog post will dive deeper into these tools, providing a detailed review of how AI is revolutionizing academic research. We’ll look at the tools that can make your literature review process less tedious, your search for relevant papers more precise, and your overall research process more efficient and fruitful.

I know that I wish these were around during my time in academia. It can be quite confronting when trying to work out what ones you should and shouldn’t use. A new one seems to be coming out every day!

Here is everything you need to know about AI for academic research and the ones I have personally trialed on my YouTube channel.

My Top AI Tools for Researchers and Academics – Tested and Reviewed!

There are many different tools now available on the market but there are only a handful that are specifically designed with researchers and academics as their primary user.

These are my recommendations that’ll cover almost everything that you’ll want to do:

Want to find out all of the tools that you could use?

Here they are, below:

AI literature search and mapping – best AI tools for a literature review – elicit and more

Harnessing AI tools for literature reviews and mapping brings a new level of efficiency and precision to academic research. No longer do you have to spend hours looking in obscure research databases to find what you need!

AI-powered tools like Semantic Scholar and elicit.org use sophisticated search engines to quickly identify relevant papers.

They can mine key information from countless PDFs, drastically reducing research time. You can even search with semantic questions, rather than having to deal with key words etc.

With AI as your research assistant, you can navigate the vast sea of scientific research with ease, uncovering citations and focusing on academic writing. It’s a revolutionary way to take on literature reviews.

• Elicit –  https://elicit.org
• Litmaps –  https://www.litmaps.com
• Research rabbit – https://www.researchrabbit.ai/
• Connected Papers –  https://www.connectedpapers.com/
• Supersymmetry.ai: https://www.supersymmetry.ai
• Semantic Scholar: https://www.semanticscholar.org
• Laser AI –  https://laser.ai/
• Inciteful –  https://inciteful.xyz/
• Scite –  https://scite.ai/
• System –  https://www.system.com

If you like AI tools you may want to check out this article:

• How to get ChatGPT to write an essay [The prompts you need]

AI-powered research tools and AI for academic research

AI research tools, like Concensus, offer immense benefits in scientific research. Here are the general AI-powered tools for academic research. 

These AI-powered tools can efficiently summarize PDFs, extract key information, and perform AI-powered searches, and much more. Some are even working towards adding your own data base of files to ask questions from. 

Tools like scite even analyze citations in depth, while AI models like ChatGPT elicit new perspectives.

The result? The research process, previously a grueling endeavor, becomes significantly streamlined, offering you time for deeper exploration and understanding. Say goodbye to traditional struggles, and hello to your new AI research assistant!

• Consensus –  https://consensus.app/
• Iris AI –  https://iris.ai/
• Research Buddy –  https://researchbuddy.app/
• Mirror Think – https://mirrorthink.ai

AI for reading peer-reviewed papers easily

Using AI tools like Explain paper and Humata can significantly enhance your engagement with peer-reviewed papers. I always used to skip over the details of the papers because I had reached saturation point with the information coming in. 

These AI-powered research tools provide succinct summaries, saving you from sifting through extensive PDFs – no more boring nights trying to figure out which papers are the most important ones for you to read!

They not only facilitate efficient literature reviews by presenting key information, but also find overlooked insights.

With AI, deciphering complex citations and accelerating research has never been easier.

• Aetherbrain – https://aetherbrain.ai
• Explain Paper – https://www.explainpaper.com
• Chat PDF – https://www.chatpdf.com
• Humata – https://www.humata.ai/
• Lateral AI –  https://www.lateral.io/
• Paper Brain –  https://www.paperbrain.study/
• Scholarcy – https://www.scholarcy.com/
• SciSpace Copilot –  https://typeset.io/
• Unriddle – https://www.unriddle.ai/
• Sharly.ai – https://www.sharly.ai/
• Open Read –  https://www.openread.academy

AI for scientific writing and research papers

In the ever-evolving realm of academic research, AI tools are increasingly taking center stage.

Enter Paper Wizard, Jenny.AI, and Wisio – these groundbreaking platforms are set to revolutionize the way we approach scientific writing.

Together, these AI tools are pioneering a new era of efficient, streamlined scientific writing.

• Jenny.AI – https://jenni.ai/ (20% off with code ANDY20)
• Yomu – https://www.yomu.ai
• Wisio – https://www.wisio.app

AI academic editing tools

In the realm of scientific writing and editing, artificial intelligence (AI) tools are making a world of difference, offering precision and efficiency like never before. Consider tools such as Paper Pal, Writefull, and Trinka.

Together, these tools usher in a new era of scientific writing, where AI is your dedicated partner in the quest for impeccable composition.

• PaperPal –  https://paperpal.com/
• Writefull –  https://www.writefull.com/
• Trinka –  https://www.trinka.ai/

AI tools for grant writing

In the challenging realm of science grant writing, two innovative AI tools are making waves: Granted AI and Grantable.

These platforms are game-changers, leveraging the power of artificial intelligence to streamline and enhance the grant application process.

Granted AI, an intelligent tool, uses AI algorithms to simplify the process of finding, applying, and managing grants. Meanwhile, Grantable offers a platform that automates and organizes grant application processes, making it easier than ever to secure funding.

Together, these tools are transforming the way we approach grant writing, using the power of AI to turn a complex, often arduous task into a more manageable, efficient, and successful endeavor.

• Granted AI – https://grantedai.com/
• Grantable – https://grantable.co/

Best free AI research tools

There are many different tools online that are emerging for researchers to be able to streamline their research processes. There’s no need for convience to come at a massive cost and break the bank.

The best free ones at time of writing are:

• Elicit – https://elicit.org
• Connected Papers – https://www.connectedpapers.com/
• Litmaps – https://www.litmaps.com ( 10% off Pro subscription using the code “STAPLETON” )
• Consensus – https://consensus.app/

Wrapping up

The integration of artificial intelligence in the world of academic research is nothing short of revolutionary.

With the array of AI tools we’ve explored today – from research and mapping, literature review, peer-reviewed papers reading, scientific writing, to academic editing and grant writing – the landscape of research is significantly transformed.

The advantages that AI-powered research tools bring to the table – efficiency, precision, time saving, and a more streamlined process – cannot be overstated.

These AI research tools aren’t just about convenience; they are transforming the way we conduct and comprehend research.

They liberate researchers from the clutches of tedium and overwhelm, allowing for more space for deep exploration, innovative thinking, and in-depth comprehension.

Whether you’re an experienced academic researcher or a student just starting out, these tools provide indispensable aid in your research journey.

And with a suite of free AI tools also available, there is no reason to not explore and embrace this AI revolution in academic research.

We are on the precipice of a new era of academic research, one where AI and human ingenuity work in tandem for richer, more profound scientific exploration. The future of research is here, and it is smart, efficient, and AI-powered.

Before we get too excited however, let us remember that AI tools are meant to be our assistants, not our masters. As we engage with these advanced technologies, let’s not lose sight of the human intellect, intuition, and imagination that form the heart of all meaningful research. Happy researching!

Thank you to Ivan Aguilar – Ph.D. Student at SFU (Simon Fraser University), for starting this list for me!

Dr Andrew Stapleton has a Masters and PhD in Chemistry from the UK and Australia. He has many years of research experience and has worked as a Postdoctoral Fellow and Associate at a number of Universities. Although having secured funding for his own research, he left academia to help others with his YouTube channel all about the inner workings of academia and how to make it work for you.

Thank you for visiting Academia Insider.

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OECD Artificial Intelligence Papers

Regulatory approaches to artificial intelligence in finance.

The OECD engages in comprehensive research and analysis to deepen insights into the transformative power of artificial intelligence (AI) and its implications for economies and societies. The OECD Artificial Intelligence Papers series draws on comprehensive evidence-base to identify trends and developments and delve into an extensive array of AI-related subjects. This includes opportunities and challenges in AI governance, the impact of AI across policy domains including labour markets, education and healthcare, ethical considerations in AI design and deployment, and new frontiers such as generative AI. This collection encompasses OECD policy papers as well as working papers.

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• ISSN: 3005348X (online)
• https://doi.org/10.1787/dee339a8-en
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UNDER EMBARGO  

The use of Artificial Intelligence (AI) in finance has increased rapidly in recent years, with the potential to deliver important benefits to market participants and to improve customer welfare. At the same time, AI in finance could also amplify existing risks in financial markets and create new ones. This report analyses different regulatory approaches to the use of AI in finance in 48 OECD and non-OECD jurisdictions based on the Survey on Regulatory Approaches to AI in Finance.

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Author(s) OECD

05 Sep 2024, 5:00 AM UTC

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Artificial intelligence: A powerful paradigm for scientific research

1 Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China

35 University of Chinese Academy of Sciences, Beijing 100049, China

5 Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China

10 Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai 200032, China

Changping Huang

18 Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China

11 Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China

37 Songshan Lake Materials Laboratory, Dongguan, Guangdong 523808, China

26 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China

Xingchen Liu

28 Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, China

2 Institute of Software, Chinese Academy of Sciences, Beijing 100190, China

Fengliang Dong

3 National Center for Nanoscience and Technology, Beijing 100190, China

Cheng-Wei Qiu

4 Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore

6 Department of Gynaecology, Obstetrics and Gynaecology Hospital, Fudan University, Shanghai 200011, China

36 Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai 200011, China

7 School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China

41 Second Affiliated Hospital School of Medicine, and School of Public Health, Zhejiang University, Hangzhou 310058, China

8 Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China

9 Zhejiang Provincial People’s Hospital, Hangzhou 310014, China

Chenguang Fu

12 School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China

Zhigang Yin

13 Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China

Ronald Roepman

14 Medical Center, Radboud University, 6500 Nijmegen, the Netherlands

Sabine Dietmann

15 Institute for Informatics, Washington University School of Medicine, St. Louis, MO 63110, USA

Marko Virta

16 Department of Microbiology, University of Helsinki, 00014 Helsinki, Finland

Fredrick Kengara

17 School of Pure and Applied Sciences, Bomet University College, Bomet 20400, Kenya

19 Agriculture College of Shihezi University, Xinjiang 832000, China

Taolan Zhao

20 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

21 The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

38 Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China

Jialiang Yang

22 Geneis (Beijing) Co., Ltd, Beijing 100102, China

23 Department of Communication Studies, Hong Kong Baptist University, Hong Kong, China

24 South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China

39 Center of Economic Botany, Core Botanical Gardens, Chinese Academy of Sciences, Guangzhou 510650, China

Zhaofeng Liu

27 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China

29 Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China

Xiaohong Liu

30 Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China

James P. Lewis

James m. tiedje.

34 Center for Microbial Ecology, Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI 48824, USA

40 Zhejiang Lab, Hangzhou 311121, China

25 Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China

31 Department of Computer Science, Aberystwyth University, Aberystwyth, Ceredigion SY23 3FL, UK

Zhipeng Cai

32 Department of Computer Science, Georgia State University, Atlanta, GA 30303, USA

33 Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China

Jiabao Zhang

Artificial intelligence (AI) coupled with promising machine learning (ML) techniques well known from computer science is broadly affecting many aspects of various fields including science and technology, industry, and even our day-to-day life. The ML techniques have been developed to analyze high-throughput data with a view to obtaining useful insights, categorizing, predicting, and making evidence-based decisions in novel ways, which will promote the growth of novel applications and fuel the sustainable booming of AI. This paper undertakes a comprehensive survey on the development and application of AI in different aspects of fundamental sciences, including information science, mathematics, medical science, materials science, geoscience, life science, physics, and chemistry. The challenges that each discipline of science meets, and the potentials of AI techniques to handle these challenges, are discussed in detail. Moreover, we shed light on new research trends entailing the integration of AI into each scientific discipline. The aim of this paper is to provide a broad research guideline on fundamental sciences with potential infusion of AI, to help motivate researchers to deeply understand the state-of-the-art applications of AI-based fundamental sciences, and thereby to help promote the continuous development of these fundamental sciences.

Graphical abstract

Public summary

• • “Can machines think?” The goal of artificial intelligence (AI) is to enable machines to mimic human thoughts and behaviors, including learning, reasoning, predicting, and so on.
• • “Can AI do fundamental research?” AI coupled with machine learning techniques is impacting a wide range of fundamental sciences, including mathematics, medical science, physics, etc.
• • “How does AI accelerate fundamental research?” New research and applications are emerging rapidly with the support by AI infrastructure, including data storage, computing power, AI algorithms, and frameworks.

Introduction

“Can machines think?” Alan Turing posed this question in his famous paper “Computing Machinery and Intelligence.” 1 He believes that to answer this question, we need to define what thinking is. However, it is difficult to define thinking clearly, because thinking is a subjective behavior. Turing then introduced an indirect method to verify whether a machine can think, the Turing test, which examines a machine's ability to show intelligence indistinguishable from that of human beings. A machine that succeeds in the test is qualified to be labeled as artificial intelligence (AI).

AI refers to the simulation of human intelligence by a system or a machine. The goal of AI is to develop a machine that can think like humans and mimic human behaviors, including perceiving, reasoning, learning, planning, predicting, and so on. Intelligence is one of the main characteristics that distinguishes human beings from animals. With the interminable occurrence of industrial revolutions, an increasing number of types of machine types continuously replace human labor from all walks of life, and the imminent replacement of human resources by machine intelligence is the next big challenge to be overcome. Numerous scientists are focusing on the field of AI, and this makes the research in the field of AI rich and diverse. AI research fields include search algorithms, knowledge graphs, natural languages processing, expert systems, evolution algorithms, machine learning (ML), deep learning (DL), and so on.

The general framework of AI is illustrated in Figure 1 . The development process of AI includes perceptual intelligence, cognitive intelligence, and decision-making intelligence. Perceptual intelligence means that a machine has the basic abilities of vision, hearing, touch, etc., which are familiar to humans. Cognitive intelligence is a higher-level ability of induction, reasoning and acquisition of knowledge. It is inspired by cognitive science, brain science, and brain-like intelligence to endow machines with thinking logic and cognitive ability similar to human beings. Once a machine has the abilities of perception and cognition, it is often expected to make optimal decisions as human beings, to improve the lives of people, industrial manufacturing, etc. Decision intelligence requires the use of applied data science, social science, decision theory, and managerial science to expand data science, so as to make optimal decisions. To achieve the goal of perceptual intelligence, cognitive intelligence, and decision-making intelligence, the infrastructure layer of AI, supported by data, storage and computing power, ML algorithms, and AI frameworks is required. Then by training models, it is able to learn the internal laws of data for supporting and realizing AI applications. The application layer of AI is becoming more and more extensive, and deeply integrated with fundamental sciences, industrial manufacturing, human life, social governance, and cyberspace, which has a profound impact on our work and lifestyle.

The general framework of AI

History of AI

The beginning of modern AI research can be traced back to John McCarthy, who coined the term “artificial intelligence (AI),” during at a conference at Dartmouth College in 1956. This symbolized the birth of the AI scientific field. Progress in the following years was astonishing. Many scientists and researchers focused on automated reasoning and applied AI for proving of mathematical theorems and solving of algebraic problems. One of the famous examples is Logic Theorist, a computer program written by Allen Newell, Herbert A. Simon, and Cliff Shaw, which proves 38 of the first 52 theorems in “Principia Mathematica” and provides more elegant proofs for some. 2 These successes made many AI pioneers wildly optimistic, and underpinned the belief that fully intelligent machines would be built in the near future. However, they soon realized that there was still a long way to go before the end goals of human-equivalent intelligence in machines could come true. Many nontrivial problems could not be handled by the logic-based programs. Another challenge was the lack of computational resources to compute more and more complicated problems. As a result, organizations and funders stopped supporting these under-delivering AI projects.

AI came back to popularity in the 1980s, as several research institutions and universities invented a type of AI systems that summarizes a series of basic rules from expert knowledge to help non-experts make specific decisions. These systems are “expert systems.” Examples are the XCON designed by Carnegie Mellon University and the MYCIN designed by Stanford University. The expert system derived logic rules from expert knowledge to solve problems in the real world for the first time. The core of AI research during this period is the knowledge that made machines “smarter.” However, the expert system gradually revealed several disadvantages, such as privacy technologies, lack of flexibility, poor versatility, expensive maintenance cost, and so on. At the same time, the Fifth Generation Computer Project, heavily funded by the Japanese government, failed to meet most of its original goals. Once again, the funding for AI research ceased, and AI was at the second lowest point of its life.

In 2006, Geoffrey Hinton and coworkers 3 , 4 made a breakthrough in AI by proposing an approach of building deeper neural networks, as well as a way to avoid gradient vanishing during training. This reignited AI research, and DL algorithms have become one of the most active fields of AI research. DL is a subset of ML based on multiple layers of neural networks with representation learning, 5 while ML is a part of AI that a computer or a program can use to learn and acquire intelligence without human intervention. Thus, “learn” is the keyword of this era of AI research. Big data technologies, and the improvement of computing power have made deriving features and information from massive data samples more efficient. An increasing number of new neural network structures and training methods have been proposed to improve the representative learning ability of DL, and to further expand it into general applications. Current DL algorithms match and exceed human capabilities on specific datasets in the areas of computer vision (CV) and natural language processing (NLP). AI technologies have achieved remarkable successes in all walks of life, and continued to show their value as backbones in scientific research and real-world applications.

Within AI, ML is having a substantial broad effect across many aspects of technology and science: from computer science to geoscience to materials science, from life science to medical science to chemistry to mathematics and to physics, from management science to economics to psychology, and other data-intensive empirical sciences, as ML methods have been developed to analyze high-throughput data to obtain useful insights, categorize, predict, and make evidence-based decisions in novel ways. To train a system by presenting it with examples of desired input-output behavior, could be far easier than to program it manually by predicting the desired response for all potential inputs. The following sections survey eight fundamental sciences, including information science (informatics), mathematics, medical science, materials science, geoscience, life science, physics, and chemistry, which develop or exploit AI techniques to promote the development of sciences and accelerate their applications to benefit human beings, society, and the world.

AI in information science

AI aims to provide the abilities of perception, cognition, and decision-making for machines. At present, new research and applications in information science are emerging at an unprecedented rate, which is inseparable from the support by the AI infrastructure. As shown in Figure 2 , the AI infrastructure layer includes data, storage and computing power, ML algorithms, and the AI framework. The perception layer enables machines have the basic ability of vision, hearing, etc. For instance, CV enables machines to “see” and identify objects, while speech recognition and synthesis helps machines to “hear” and recognize speech elements. The cognitive layer provides higher ability levels of induction, reasoning, and acquiring knowledge with the help of NLP, 6 knowledge graphs, 7 and continual learning. 8 In the decision-making layer, AI is capable of making optimal decisions, such as automatic planning, expert systems, and decision-supporting systems. Numerous applications of AI have had a profound impact on fundamental sciences, industrial manufacturing, human life, social governance, and cyberspace. The following subsections provide an overview of the AI framework, automatic machine learning (AutoML) technology, and several state-of-the-art AI/ML applications in the information field.

The knowledge graph of the AI framework

The AI framework provides basic tools for AI algorithm implementation

In the past 10 years, applications based on AI algorithms have played a significant role in various fields and subjects, on the basis of which the prosperity of the DL framework and platform has been founded. AI frameworks and platforms reduce the requirement of accessing AI technology by integrating the overall process of algorithm development, which enables researchers from different areas to use it across other fields, allowing them to focus on designing the structure of neural networks, thus providing better solutions to problems in their fields. At the beginning of the 21st century, only a few tools, such as MATLAB, OpenNN, and Torch, were capable of describing and developing neural networks. However, these tools were not originally designed for AI models, and thus faced problems, such as complicated user API and lacking GPU support. During this period, using these frameworks demanded professional computer science knowledge and tedious work on model construction. As a solution, early frameworks of DL, such as Caffe, Chainer, and Theano, emerged, allowing users to conveniently construct complex deep neural networks (DNNs), such as convolutional neural networks (CNNs), recurrent neural networks (RNNs), and LSTM conveniently, and this significantly reduced the cost of applying AI models. Tech giants then joined the march in researching AI frameworks. 9 Google developed the famous open-source framework, TensorFlow, while Facebook's AI research team released another popular platform, PyTorch, which is based on Torch; Microsoft Research published CNTK, and Amazon announced MXNet. Among them, TensorFlow, also the most representative framework, referred to Theano's declarative programming style, offering a larger space for graph-based optimization, while PyTorch inherited the imperative programming style of Torch, which is intuitive, user friendly, more flexible, and easier to be traced. As modern AI frameworks and platforms are being widely applied, practitioners can now assemble models swiftly and conveniently by adopting various building block sets and languages specifically suitable for given fields. Polished over time, these platforms gradually developed a clearly defined user API, the ability for multi-GPU training and distributed training, as well as a variety of model zoos and tool kits for specific tasks. 10 Looking forward, there are a few trends that may become the mainstream of next-generation framework development. (1) Capability of super-scale model training. With the emergence of models derived from Transformer, such as BERT and GPT-3, the ability of training large models has become an ideal feature of the DL framework. It requires AI frameworks to train effectively under the scale of hundreds or even thousands of devices. (2) Unified API standard. The APIs of many frameworks are generally similar but slightly different at certain points. This leads to some difficulties and unnecessary learning efforts, when the user attempts to shift from one framework to another. The API of some frameworks, such as JAX, has already become compatible with Numpy standard, which is familiar to most practitioners. Therefore, a unified API standard for AI frameworks may gradually come into being in the future. (3) Universal operator optimization. At present, kernels of DL operator are implemented either manually or based on third-party libraries. Most third-party libraries are developed to suit certain hardware platforms, causing large unnecessary spending when models are trained or deployed on different hardware platforms. The development speed of new DL algorithms is usually much faster than the update rate of libraries, which often makes new algorithms to be beyond the range of libraries' support. 11

To improve the implementation speed of AI algorithms, much research focuses on how to use hardware for acceleration. The DianNao family is one of the earliest research innovations on AI hardware accelerators. 12 It includes DianNao, DaDianNao, ShiDianNao, and PuDianNao, which can be used to accelerate the inference speed of neural networks and other ML algorithms. Of these, the best performance of a 64-chip DaDianNao system can achieve a speed up of 450.65× over a GPU, and reduce the energy by 150.31×. Prof. Chen and his team in the Institute of Computing Technology also designed an Instruction Set Architecture for a broad range of neural network accelerators, called Cambricon, which developed into a serial DL accelerator. After Cambricon, many AI-related companies, such as Apple, Google, HUAWEI, etc., developed their own DL accelerators, and AI accelerators became an important research field of AI.

AI for AI—AutoML

AutoML aims to study how to use evolutionary computing, reinforcement learning (RL), and other AI algorithms, to automatically generate specified AI algorithms. Research on the automatic generation of neural networks has existed before the emergence of DL, e.g., neural evolution. 13 The main purpose of neural evolution is to allow neural networks to evolve according to the principle of survival of the fittest in the biological world. Through selection, crossover, mutation, and other evolutionary operators, the individual quality in a population is continuously improved and, finally, the individual with the greatest fitness represents the best neural network. The biological inspiration in this field lies in the evolutionary process of human brain neurons. The human brain has such developed learning and memory functions that it cannot do without the complex neural network system in the brain. The whole neural network system of the human brain benefits from a long evolutionary process rather than gradient descent and back propagation. In the era of DL, the application of AI algorithms to automatically generate DNN has attracted more attention and, gradually, developed into an important direction of AutoML research: neural architecture search. The implementation methods of neural architecture search are usually divided into the RL-based method and the evolutionary algorithm-based method. In the RL-based method, an RNN is used as a controller to generate a neural network structure layer by layer, and then the network is trained, and the accuracy of the verification set is used as the reward signal of the RNN to calculate the strategy gradient. During the iteration, the controller will give the neural network, with higher accuracy, a higher probability value, so as to ensure that the strategy function can output the optimal network structure. 14 The method of neural architecture search through evolution is similar to the neural evolution method, which is based on a population and iterates continuously according to the principle of survival of the fittest, so as to obtain a high-quality neural network. 15 Through the application of neural architecture search technology, the design of neural networks is more efficient and automated, and the accuracy of the network gradually outperforms that of the networks designed by AI experts. For example, Google's SOTA network EfficientNet was realized through the baseline network based on neural architecture search. 16

AI enabling networking design adaptive to complex network conditions

The application of DL in the networking field has received strong interest. Network design often relies on initial network conditions and/or theoretical assumptions to characterize real network environments. However, traditional network modeling and design, regulated by mathematical models, are unlikely to deal with complex scenarios with many imperfect and high dynamic network environments. Integrating DL into network research allows for a better representation of complex network environments. Furthermore, DL could be combined with the Markov decision process and evolve into the deep reinforcement learning (DRL) model, which finds an optimal policy based on the reward function and the states of the system. Taken together, these techniques could be used to make better decisions to guide proper network design, thereby improving the network quality of service and quality of experience. With regard to the aspect of different layers of the network protocol stack, DL/DRL can be adopted for network feature extraction, decision-making, etc. In the physical layer, DL can be used for interference alignment. It can also be used to classify the modulation modes, design efficient network coding 17 and error correction codes, etc. In the data link layer, DL can be used for resource (such as channels) allocation, medium access control, traffic prediction, 18 link quality evaluation, and so on. In the network (routing) layer, routing establishment and routing optimization 19 can help to obtain an optimal routing path. In higher layers (such as the application layer), enhanced data compression and task allocation is used. Besides the above protocol stack, one critical area of using DL is network security. DL can be used to classify the packets into benign/malicious types, and how it can be integrated with other ML schemes, such as unsupervised clustering, to achieve a better anomaly detection effect.

AI enabling more powerful and intelligent nanophotonics

Nanophotonic components have recently revolutionized the field of optics via metamaterials/metasurfaces by enabling the arbitrary manipulation of light-matter interactions with subwavelength meta-atoms or meta-molecules. 20 , 21 , 22 The conventional design of such components involves generally forward modeling, i.e., solving Maxwell's equations based on empirical and intuitive nanostructures to find corresponding optical properties, as well as the inverse design of nanophotonic devices given an on-demand optical response. The trans-dimensional feature of macro-optical components consisting of complex nano-antennas makes the design process very time consuming, computationally expensive, and even numerically prohibitive, such as device size and complexity increase. DL is an efficient and automatic platform, enabling novel efficient approaches to designing nanophotonic devices with high-performance and versatile functions. Here, we present briefly the recent progress of DL-based nanophotonics and its wide-ranging applications. DL was exploited for forward modeling at first using a DNN. 23 The transmission or reflection coefficients can be well predicted after training on huge datasets. To improve the prediction accuracy of DNN in case of small datasets, transfer learning was introduced to migrate knowledge between different physical scenarios, which greatly reduced the relative error. Furthermore, a CNN and an RNN were developed for the prediction of optical properties from arbitrary structures using images. 24 The CNN-RNN combination successfully predicted the absorption spectra from the given input structural images. In inverse design of nanophotonic devices, there are three different paradigms of DL methods, i.e., supervised, unsupervised, and RL. 25 Supervised learning has been utilized to design structural parameters for the pre-defined geometries, such as tandem DNN and bidirectional DNNs. Unsupervised learning methods learn by themselves without a specific target, and thus are more accessible to discovering new and arbitrary patterns 26 in completely new data than supervised learning. A generative adversarial network (GAN)-based approach, combining conditional GANs and Wasserstein GANs, was proposed to design freeform all-dielectric multifunctional metasurfaces. RL, especially double-deep Q-learning, powers up the inverse design of high-performance nanophotonic devices. 27 DL has endowed nanophotonic devices with better performance and more emerging applications. 28 , 29 For instance, an intelligent microwave cloak driven by DL exhibits millisecond and self-adaptive response to an ever-changing incident wave and background. 28 Another example is that a DL-augmented infrared nanoplasmonic metasurface is developed for monitoring dynamics between four major classes of bio-molecules, which could impact the fields of biology, bioanalytics, and pharmacology from fundamental research, to disease diagnostics, to drug development. 29 The potential of DL in the wide arena of nanophotonics has been unfolding. Even end-users without optics and photonics background could exploit the DL as a black box toolkit to design powerful optical devices. Nevertheless, how to interpret/mediate the intermediate DL process and determine the most dominant factors in the search for optimal solutions, are worthy of being investigated in depth. We optimistically envisage that the advancements in DL algorithms and computation/optimization infrastructures would enable us to realize more efficient and reliable training approaches, more complex nanostructures with unprecedented shapes and sizes, and more intelligent and reconfigurable optic/optoelectronic systems.

AI in other fields of information science

We believe that AI has great potential in the following directions:

• • AI-based risk control and management in utilities can prevent costly or hazardous equipment failures by using sensors that detect and send information regarding the machine's health to the manufacturer, predicting possible issues that could occur so as to ensure timely maintenance or automated shutdown.
• • AI could be used to produce simulations of real-world objects, called digital twins. When applied to the field of engineering, digital twins allow engineers and technicians to analyze the performance of an equipment virtually, thus avoiding safety and budget issues associated with traditional testing methods.
• • Combined with AI, intelligent robots are playing an important role in industry and human life. Different from traditional robots working according to the procedures specified by humans, intelligent robots have the ability of perception, recognition, and even automatic planning and decision-making, based on changes in environmental conditions.
• • AI of things (AIoT) or AI-empowered IoT applications. 30 have become a promising development trend. AI can empower the connected IoT devices, embedded in various physical infrastructures, to perceive, recognize, learn, and act. For instance, smart cities constantly collect data regarding quality-of-life factors, such as the status of power supply, public transportation, air pollution, and water use, to manage and optimize systems in cities. Due to these data, especially personal data being collected from informed or uninformed participants, data security, and privacy 31 require protection.

AI in mathematics

Mathematics always plays a crucial and indispensable role in AI. Decades ago, quite a few classical AI-related approaches, such as k-nearest neighbor, 32 support vector machine, 33 and AdaBoost, 34 were proposed and developed after their rigorous mathematical formulations had been established. In recent years, with the rapid development of DL, 35 AI has been gaining more and more attention in the mathematical community. Equipped with the Markov process, minimax optimization, and Bayesian statistics, RL, 36 GANs, 37 and Bayesian learning 38 became the most favorable tools in many AI applications. Nevertheless, there still exist plenty of open problems in mathematics for ML, including the interpretability of neural networks, the optimization problems of parameter estimation, and the generalization ability of learning models. In the rest of this section, we discuss these three questions in turn.

The interpretability of neural networks

From a mathematical perspective, ML usually constructs nonlinear models, with neural networks as a typical case, to approximate certain functions. The well-known Universal Approximation Theorem suggests that, under very mild conditions, any continuous function can be uniformly approximated on compact domains by neural networks, 39 which serves a vital function in the interpretability of neural networks. However, in real applications, ML models seem to admit accurate approximations of many extremely complicated functions, sometimes even black boxes, which are far beyond the scope of continuous functions. To understand the effectiveness of ML models, many researchers have investigated the function spaces that can be well approximated by them, and the corresponding quantitative measures. This issue is closely related to the classical approximation theory, but the approximation scheme is distinct. For example, Bach 40 finds that the random feature model is naturally associated with the corresponding reproducing kernel Hilbert space. In the same way, the Barron space is identified as the natural function space associated with two-layer neural networks, and the approximation error is measured using the Barron norm. 41 The corresponding quantities of residual networks (ResNets) are defined for the flow-induced spaces. For multi-layer networks, the natural function spaces for the purposes of approximation theory are the tree-like function spaces introduced in Wojtowytsch. 42 There are several works revealing the relationship between neural networks and numerical algorithms for solving partial differential equations. For example, He and Xu 43 discovered that CNNs for image classification have a strong connection with multi-grid (MG) methods. In fact, the pooling operation and feature extraction in CNNs correspond directly to restriction operation and iterative smoothers in MG, respectively. Hence, various convolution and pooling operations used in CNNs can be better understood.

The optimization problems of parameter estimation

In general, the optimization problem of estimating parameters of certain DNNs is in practice highly nonconvex and often nonsmooth. Can the global minimizers be expected? What is the landscape of local minimizers? How does one handle the nonsmoothness? All these questions are nontrivial from an optimization perspective. Indeed, numerous works and experiments demonstrate that the optimization for parameter estimation in DL is itself a much nicer problem than once thought; see, e.g., Goodfellow et al. 44 As a consequence, the study on the solution landscape ( Figure 3 ), also known as loss surface of neural networks, is no longer supposed to be inaccessible and can even in turn provide guidance for global optimization. Interested readers can refer to the survey paper (Sun et al. 45 ) for recent progress in this aspect.

Recent studies indicate that nonsmooth activation functions, e.g., rectified linear units, are better than smooth ones in finding sparse solutions. However, the chain rule does not work in the case that the activation functions are nonsmooth, which then makes the widely used stochastic gradient (SG)-based approaches not feasible in theory. Taking approximated gradients at nonsmooth iterates as a remedy ensures that SG-type methods are still in extensive use, but that the numerical evidence has also exposed their limitations. Also, the penalty-based approaches proposed by Cui et al. 46 and Liu et al. 47 provide a new direction to solve the nonsmooth optimization problems efficiently.

The generalization ability of learning models

A small training error does not always lead to a small test error. This gap is caused by the generalization ability of learning models. A key finding in statistical learning theory states that the generalization error is bounded by a quantity that grows with the increase of the model capacity, but shrinks as the number of training examples increases. 48 A common conjecture relating generalization to solution landscape is that flat and wide minima generalize better than sharp ones. Thus, regularization techniques, including the dropout approach, 49 have emerged to force the algorithms to bypass the sharp minima. However, the mechanism behind this has not been fully explored. Recently, some researchers have focused on the ResNet-type architecture, with dropout being inserted after the last convolutional layer of each modular building. They thus managed to explain the stochastic dropout training process and the ensuing dropout regularization effect from the perspective of optimal control. 50

AI in medical science

There is a great trend for AI technology to grow more and more significant in daily operations, including medical fields. With the growing needs of healthcare for patients, hospital needs are evolving from informationization networking to the Internet Hospital and eventually to the Smart Hospital. At the same time, AI tools and hardware performance are also growing rapidly with each passing day. Eventually, common AI algorithms, such as CV, NLP, and data mining, will begin to be embedded in the medical equipment market ( Figure 4 ).

AI doctor based on electronic medical records

For medical history data, it is inevitable to mention Doctor Watson, developed by the Watson platform of IBM, and Modernizing Medicine, which aims to solve oncology, and is now adopted by CVS & Walgreens in the US and various medical organizations in China as well. Doctor Watson takes advantage of the NLP performance of the IBM Watson platform, which already collected vast data of medical history, as well as prior knowledge in the literature for reference. After inputting the patients' case, Doctor Watson searches the medical history reserve and forms an elementary treatment proposal, which will be further ranked by prior knowledge reserves. With the multiple models stored, Doctor Watson gives the final proposal as well as the confidence of the proposal. However, there are still problems for such AI doctors because, 51 as they rely on prior experience from US hospitals, the proposal may not be suitable for other regions with different medical insurance policies. Besides, the knowledge updating of the Watson platform also relies highly on the updating of the knowledge reserve, which still needs manual work.

AI for public health: Outbreak detection and health QR code for COVID-19

AI can be used for public health purposes in many ways. One classical usage is to detect disease outbreaks using search engine query data or social media data, as Google did for prediction of influenza epidemics 52 and the Chinese Academy of Sciences did for modeling the COVID-19 outbreak through multi-source information fusion. 53 After the COVID-19 outbreak, a digital health Quick Response (QR) code system has been developed by China, first to detect potential contact with confirmed COVID-19 cases and, secondly, to indicate the person's health status using mobile big data. 54 Different colors indicate different health status: green means healthy and is OK for daily life, orange means risky and requires quarantine, and red means confirmed COVID-19 patient. It is easy to use for the general public, and has been adopted by many other countries. The health QR code has made great contributions to the worldwide prevention and control of the COVID-19 pandemic.

Biomarker discovery with AI

High-dimensional data, including multi-omics data, patient characteristics, medical laboratory test data, etc., are often used for generating various predictive or prognostic models through DL or statistical modeling methods. For instance, the COVID-19 severity evaluation model was built through ML using proteomic and metabolomic profiling data of sera 55 ; using integrated genetic, clinical, and demographic data, Taliaz et al. built an ML model to predict patient response to antidepressant medications 56 ; prognostic models for multiple cancer types (such as liver cancer, lung cancer, breast cancer, gastric cancer, colorectal cancer, pancreatic cancer, prostate cancer, ovarian cancer, lymphoma, leukemia, sarcoma, melanoma, bladder cancer, renal cancer, thyroid cancer, head and neck cancer, etc.) were constructed through DL or statistical methods, such as least absolute shrinkage and selection operator （LASSO）, combined with Cox proportional hazards regression model using genomic data. 57

Image-based medical AI

Medical image AI is one of the most developed mature areas as there are numerous models for classification, detection, and segmentation tasks in CV. For the clinical area, CV algorithms can also be used for computer-aided diagnosis and treatment with ECG, CT, eye fundus imaging, etc. As human doctors may be tired and prone to make mistakes after viewing hundreds and hundreds of images for diagnosis, AI doctors can outperform a human medical image viewer due to their specialty at repeated work without fatigue. The first medical AI product approved by FDA is IDx-DR, which uses an AI model to make predictions of diabetic retinopathy. The smartphone app SkinVision can accurately detect melanomas. 58 It uses “fractal analysis” to identify moles and their surrounding skin, based on size, diameter, and many other parameters, and to detect abnormal growth trends. AI-ECG of LEPU Medical can automatically detect heart disease with ECG images. Lianying Medical takes advantage of their hardware equipment to produce real-time high-definition image-guided all-round radiotherapy technology, which successfully achieves precise treatment.

Wearable devices for surveillance and early warning

For wearable devices, AliveCor has developed an algorithm to automatically predict the presence of atrial fibrillation, which is an early warning sign of stroke and heart failure. The 23andMe company can also test saliva samples at a small cost, and a customer can be provided with information based on their genes, including who their ancestors were or potential diseases they may be prone to later in life. It provides accurate health management solutions based on individual and family genetic data. In the 20–30 years of the near feature, we believe there are several directions for further research: (1) causal inference for real-time in-hospital risk prediction. Clinical doctors usually acquire reasonable explanations for certain medical decisions, but the current AI models nowadays are usually black box models. The casual inference will help doctors to explain certain AI decisions and even discover novel ground truths. (2) Devices, including wearable instruments for multi-dimensional health monitoring. The multi-modality model is now a trend for AI research. With various devices to collect multi-modality data and a central processor to fuse all these data, the model can monitor the user's overall real-time health condition and give precautions more precisely. (3) Automatic discovery of clinical markers for diseases that are difficult to diagnose. Diseases, such as ALS, are still difficult for clinical doctors to diagnose because they lack any effective general marker. It may be possible for AI to discover common phenomena for these patients and find an effective marker for early diagnosis.

AI-aided drug discovery

Today we have come into the precision medicine era, and the new targeted drugs are the cornerstones for precision therapy. However, over the past decades, it takes an average of over one billion dollars and 10 years to bring a new drug into the market. How to accelerate the drug discovery process, and avoid late-stage failure, are key concerns for all the big and fiercely competitive pharmaceutical companies. The highlighted emerging role of AI, including ML, DL, expert systems, and artificial neural networks (ANNs), has brought new insights and high efficiency into the new drug discovery processes. AI has been adopted in many aspects of drug discovery, including de novo molecule design, structure-based modeling for proteins and ligands, quantitative structure-activity relationship research, and druggable property judgments. DL-based AI appliances demonstrate superior merits in addressing some challenging problems in drug discovery. Of course, prediction of chemical synthesis routes and chemical process optimization are also valuable in accelerating new drug discovery, as well as lowering production costs.

There has been notable progress in the AI-aided new drug discovery in recent years, for both new chemical entity discovery and the relating business area. Based on DNNs, DeepMind built the AlphaFold platform to predict 3D protein structures that outperformed other algorithms. As an illustration of great achievement, AlphaFold successfully and accurately predicted 25 scratch protein structures from a 43 protein panel without using previously built proteins models. Accordingly, AlphaFold won the CASP13 protein-folding competition in December 2018. 59 Based on the GANs and other ML methods, Insilico constructed a modular drug design platform GENTRL system. In September 2019, they reported the discovery of the first de novo active DDR1 kinase inhibitor developed by the GENTRL system. It took the team only 46 days from target selection to get an active drug candidate using in vivo data. 60 Exscientia and Sumitomo Dainippon Pharma developed a new drug candidate, DSP-1181, for the treatment of obsessive-compulsive disorder on the Centaur Chemist AI platform. In January 2020, DSP-1181 started its phase I clinical trials, which means that, from program initiation to phase I study, the comprehensive exploration took less than 12 months. In contrast, comparable drug discovery using traditional methods usually needs 4–5 years with traditional methods.

How AI transforms medical practice: A case study of cervical cancer

As the most common malignant tumor in women, cervical cancer is a disease that has a clear cause and can be prevented, and even treated, if detected early. Conventionally, the screening strategy for cervical cancer mainly adopts the “three-step” model of “cervical cytology-colposcopy-histopathology.” 61 However, limited by the level of testing methods, the efficiency of cervical cancer screening is not high. In addition, owing to the lack of knowledge by doctors in some primary hospitals, patients cannot be provided with the best diagnosis and treatment decisions. In recent years, with the advent of the era of computer science and big data, AI has gradually begun to extend and blend into various fields. In particular, AI has been widely used in a variety of cancers as a new tool for data mining. For cervical cancer, a clinical database with millions of medical records and pathological data has been built, and an AI medical tool set has been developed. 62 Such an AI analysis algorithm supports doctors to access the ability of rapid iterative AI model training. In addition, a prognostic prediction model established by ML and a web-based prognostic result calculator have been developed, which can accurately predict the risk of postoperative recurrence and death in cervical cancer patients, and thereby better guide decision-making in postoperative adjuvant treatment. 63

AI in materials science

As the cornerstone of modern industry, materials have played a crucial role in the design of revolutionary forms of matter, with targeted properties for broad applications in energy, information, biomedicine, construction, transportation, national security, spaceflight, and so forth. Traditional strategies rely on the empirical trial and error experimental approaches as well as the theoretical simulation methods, e.g., density functional theory, thermodynamics, or molecular dynamics, to discover novel materials. 64 These methods often face the challenges of long research cycles, high costs, and low success rates, and thus cannot meet the increasingly growing demands of current materials science. Accelerating the speed of discovery and deployment of advanced materials will therefore be essential in the coming era.

With the rapid development of data processing and powerful algorithms, AI-based methods, such as ML and DL, are emerging with good potentials in the search for and design of new materials prior to actually manufacturing them. 65 , 66 By integrating material property data, such as the constituent element, lattice symmetry, atomic radius, valence, binding energy, electronegativity, magnetism, polarization, energy band, structure-property relation, and functionalities, the machine can be trained to “think” about how to improve material design and even predict the properties of new materials in a cost-effective manner ( Figure 5 ).

AI is expected to power the development of materials science

AI in discovery and design of new materials

Recently, AI techniques have made significant advances in rational design and accelerated discovery of various materials, such as piezoelectric materials with large electrostrains, 67 organic-inorganic perovskites for photovoltaics, 68 molecular emitters for efficient light-emitting diodes, 69 inorganic solid materials for thermoelectrics, 70 and organic electronic materials for renewable-energy applications. 66 , 71 The power of data-driven computing and algorithmic optimization can promote comprehensive applications of simulation and ML (i.e., high-throughput virtual screening, inverse molecular design, Bayesian optimization, and supervised learning, etc.), in material discovery and property prediction in various fields. 72 For instance, using a DL Bayesian framework, the attribute-driven inverse materials design has been demonstrated for efficient and accurate prediction of functional molecular materials, with desired semiconducting properties or redox stability for applications in organic thin-film transistors, organic solar cells, or lithium-ion batteries. 73 It is meaningful to adopt automation tools for quick experimental testing of potential materials and utilize high-performance computing to calculate their bulk, interface, and defect-related properties. 74 The effective convergence of automation, computing, and ML can greatly speed up the discovery of materials. In the future, with the aid of AI techniques, it will be possible to accomplish the design of superconductors, metallic glasses, solder alloys, high-entropy alloys, high-temperature superalloys, thermoelectric materials, two-dimensional materials, magnetocaloric materials, polymeric bio-inspired materials, sensitive composite materials, and topological (electronic and phonon) materials, and so on. In the past decade, topological materials have ignited the research enthusiasm of condensed matter physicists, materials scientists, and chemists, as they exhibit exotic physical properties with potential applications in electronics, thermoelectrics, optics, catalysis, and energy-related fields. From the most recent predictions, more than a quarter of all inorganic materials in nature are topologically nontrivial. The establishment of topological electronic materials databases 75 , 76 , 77 and topological phononic materials databases 78 using high-throughput methods will help to accelerate the screening and experimental discovery of new topological materials for functional applications. It is recognized that large-scale high-quality datasets are required to practice AI. Great efforts have also been expended in building high-quality materials science databases. As one of the top-ranking databases of its kind, the “atomly.net” materials data infrastructure, 79 has calculated the properties of more than 180,000 inorganic compounds, including their equilibrium structures, electron energy bands, dielectric properties, simulated diffraction patterns, elasticity tensors, etc. As such, the atomly.net database has set a solid foundation for extending AI into the area of materials science research. The X-ray diffraction (XRD)-matcher model of atomly.net uses ML to match and classify the experimental XRD to the simulated patterns. Very recently, by using the dataset from atomly.net, an accurate AI model was built to rapidly predict the formation energy of almost any given compound to yield a fairly good predictive ability. 80

AI-powered Materials Genome Initiative

The Materials Genome Initiative (MGI) is a great plan for rational realization of new materials and related functions, and it aims to discover, manufacture, and deploy advanced materials efficiently, cost-effectively, and intelligently. The initiative creates policy, resources, and infrastructure for accelerating materials development at a high level. This is a new paradigm for the discovery and design of next-generation materials, and runs from a view point of fundamental building blocks toward general materials developments, and accelerates materials development through efforts in theory, computation, and experiment, in a highly integrated high-throughput manner. MGI raises an ultimately high goal and high level for materials development and materials science for humans in the future. The spirit of MGI is to design novel materials by using data pools and powerful computation once the requirements or aspirations of functional usages appear. The theory, computation, and algorithm are the primary and substantial factors in the establishment and implementation of MGI. Advances in theories, computations, and experiments in materials science and engineering provide the footstone to not only accelerate the speed at which new materials are realized but to also shorten the time needed to push new products into the market. These AI techniques bring a great promise to the developing MGI. The applications of new technologies, such as ML and DL, directly accelerate materials research and the establishment of MGI. The model construction and application to science and engineering, as well as the data infrastructure, are of central importance. When the AI-powered MGI approaches are coupled with the ongoing autonomy of manufacturing methods, the potential impact to society and the economy in the future is profound. We are now beginning to see that the AI-aided MGI, among other things, integrates experiments, computation, and theory, and facilitates access to materials data, equips the next generation of the materials workforce, and enables a paradigm shift in materials development. Furthermore, the AI-powdered MGI could also design operational procedures and control the equipment to execute experiments, and to further realize autonomous experimentation in future material research.

Advanced functional materials for generation upgrade of AI

The realization and application of AI techniques depend on the computational capability and computer hardware, and this bases physical functionality on the performance of computers or supercomputers. For our current technology, the electric currents or electric carriers for driving electric chips and devices consist of electrons with ordinary characteristics, such as heavy mass and low mobility. All chips and devices emit relatively remarkable heat levels, consuming too much energy and lowering the efficiency of information transmission. Benefiting from the rapid development of modern physics, a series of advanced materials with exotic functional effects have been discovered or designed, including superconductors, quantum anomalous Hall insulators, and topological fermions. In particular, the superconducting state or topologically nontrivial electrons will promote the next-generation AI techniques once the (near) room temperature applications of these states are realized and implanted in integrated circuits. 81 In this case, the central processing units, signal circuits, and power channels will be driven based on the electronic carriers that show massless, energy-diffusionless, ultra-high mobility, or chiral-protection characteristics. The ordinary electrons will be removed from the physical circuits of future-generation chips and devices, leaving superconducting and topological chiral electrons running in future AI chips and supercomputers. The efficiency of transmission, for information and logic computing will be improved on a vast scale and at a very low cost.

AI for materials and materials for AI

The coming decade will continue to witness the development of advanced ML algorithms, newly emerging data-driven AI methodologies, and integrated technologies for facilitating structure design and property prediction, as well as to accelerate the discovery, design, development, and deployment of advanced materials into existing and emerging industrial sectors. At this moment, we are facing challenges in achieving accelerated materials research through the integration of experiment, computation, and theory. The great MGI, proposed for high-level materials research, helps to promote this process, especially when it is assisted by AI techniques. Still, there is a long way to go for the usage of these advanced functional materials in future-generation electric chips and devices to be realized. More materials and functional effects need to be discovered or improved by the developing AI techniques. Meanwhile, it is worth noting that materials are the core components of devices and chips that are used for construction of computers or machines for advanced AI systems. The rapid development of new materials, especially the emergence of flexible, sensitive, and smart materials, is of great importance for a broad range of attractive technologies, such as flexible circuits, stretchable tactile sensors, multifunctional actuators, transistor-based artificial synapses, integrated networks of semiconductor/quantum devices, intelligent robotics, human-machine interactions, simulated muscles, biomimetic prostheses, etc. These promising materials, devices, and integrated technologies will greatly promote the advancement of AI systems toward wide applications in human life. Once the physical circuits are upgraded by advanced functional or smart materials, AI techniques will largely promote the developments and applications of all disciplines.

AI in geoscience

Ai technologies involved in a large range of geoscience fields.

Momentous challenges threatening current society require solutions to problems that belong to geoscience, such as evaluating the effects of climate change, assessing air quality, forecasting the effects of disaster incidences on infrastructure, by calculating the incoming consumption and availability of food, water, and soil resources, and identifying factors that are indicators for potential volcanic eruptions, tsunamis, floods, and earthquakes. 82 , 83 It has become possible, with the emergence of advanced technology products (e.g., deep sea drilling vessels and remote sensing satellites), for enhancements in computational infrastructure that allow for processing large-scale, wide-range simulations of multiple models in geoscience, and internet-based data analysis that facilitates collection, processing, and storage of data in distributed and crowd-sourced environments. 84 The growing availability of massive geoscience data provides unlimited possibilities for AI—which has popularized all aspects of our daily life (e.g., entertainment, transportation, and commerce)—to significantly contribute to geoscience problems of great societal relevance. As geoscience enters the era of massive data, AI, which has been extensively successful in different fields, offers immense opportunities for settling a series of problems in Earth systems. 85 , 86 Accompanied by diversified data, AI-enabled technologies, such as smart sensors, image visualization, and intelligent inversion, are being actively examined in a large range of geoscience fields, such as marine geoscience, rock physics, geology, ecology, seismicity, environment, hydrology, remote sensing, Arc GIS, and planetary science. 87

Multiple challenges in the development of geoscience

There are some traits of geoscience development that restrict the applicability of fundamental algorithms for knowledge discovery: (1) inherent challenges of geoscience processes, (2) limitation of geoscience data collection, and (3) uncertainty in samples and ground truth. 88 , 89 , 90 Amorphous boundaries generally exist in geoscience objects between space and time that are not as well defined as objects in other fields. Geoscience phenomena are also significantly multivariate, obey nonlinear relationships, and exhibit spatiotemporal structure and non-stationary characteristics. Except for the inherent challenges of geoscience observations, the massive data at multiple dimensions of time and space, with different levels of incompleteness, noise, and uncertainties, disturb processes in geoscience. For supervised learning approaches, there are other difficulties owing to the lack of gold standard ground truth and the “small size” of samples (e.g., a small amount of historical data with sufficient observations) in geoscience applications.

Usage of AI technologies as efficient approaches to promote the geoscience processes

Geoscientists continually make every effort to develop better techniques for simulating the present status of the Earth system (e.g., how much greenhouse gases are released into the atmosphere), and the connections between and within its subsystems (e.g., how does the elevated temperature influence the ocean ecosystem). Viewed from the perspective of geoscience, newly emerging approaches, with the aid of AI, are a perfect combination for these issues in the application of geoscience: (1) characterizing objects and events 91 ; (2) estimating geoscience variables from observations 92 ; (3) forecasting geoscience variables according to long-term observations 85 ; (4) exploring geoscience data relationships 93 ; and (5) causal discovery and causal attribution. 94 While characterizing geoscience objects and events using traditional methods are primarily rooted in hand-coded features, algorithms can automatically detect the data by improving the performance with pattern-mining techniques. However, due to spatiotemporal targets with vague boundaries and the related uncertainties, it can be necessary to advance pattern-mining methods that can explain the temporal and spatial characteristics of geoscience data when characterizing different events and objects. To address the non-stationary issue of geoscience data, AI-aided algorithms have been expanded to integrate the holistic results of professional predictors and engender robust estimations of climate variables (e.g., humidity and temperature). Furthermore, forecasting long-term trends of the current situation in the Earth system using AI-enabled technologies can simulate future scenarios and formulate early resource planning and adaptation policies. Mining geoscience data relationships can help us seize vital signs of the Earth system and promote our understanding of geoscience developments. Of great interest is the advancement of AI-decision methodology with uncertain prediction probabilities, engendering vague risks with poorly resolved tails, signifying the most extreme, transient, and rare events formulated by model sets, which supports various cases to improve accuracy and effectiveness.

AI technologies for optimizing the resource management in geoscience

Currently, AI can perform better than humans in some well-defined tasks. For example, AI techniques have been used in urban water resource planning, mainly due to their remarkable capacity for modeling, flexibility, reasoning, and forecasting the water demand and capacity. Design and application of an Adaptive Intelligent Dynamic Water Resource Planning system, the subset of AI for sustainable water resource management in urban regions, largely prompted the optimization of water resource allocation, will finally minimize the operation costs and improve the sustainability of environmental management 95 ( Figure 6 ). Also, meteorology requires collecting tremendous amounts of data on many different variables, such as humidity, altitude, and temperature; however, dealing with such a huge dataset is a big challenge. 96 An AI-based technique is being utilized to analyze shallow-water reef images, recognize the coral color—to track the effects of climate change, and to collect humidity, temperature, and CO 2 data—to grasp the health of our ecological environment. 97 Beyond AI's capabilities for meteorology, it can also play a critical role in decreasing greenhouse gas emissions originating from the electric-power sector. Comprised of production, transportation, allocation, and consumption of electricity, many opportunities exist in the electric-power sector for Al applications, including speeding up the development of new clean energy, enhancing system optimization and management, improving electricity-demand forecasts and distribution, and advancing system monitoring. 98 New materials may even be found, with the auxiliary of AI, for batteries to store energy or materials and absorb CO 2 from the atmosphere. 99 Although traditional fossil fuel operations have been widely used for thousands of years, AI techniques are being used to help explore the development of more potential sustainable energy sources for the development (e.g., fusion technology). 100

Applications of AI in hydraulic resource management

In addition to the adjustment of energy structures due to climate change (a core part of geoscience systems), a second, less-obvious step could also be taken to reduce greenhouse gas emission: using AI to target inefficiencies. A related statistical report by the Lawrence Livermore National Laboratory pointed out that around 68% of energy produced in the US could be better used for purposeful activities, such as electricity generation or transportation, but is instead contributing to environmental burdens. 101 AI is primed to reduce these inefficiencies of current nuclear power plants and fossil fuel operations, as well as improve the efficiency of renewable grid resources. 102 For example, AI can be instrumental in the operation and optimization of solar and wind farms to make these utility-scale renewable-energy systems far more efficient in the production of electricity. 103 AI can also assist in reducing energy losses in electricity transportation and allocation. 104 A distribution system operator in Europe used AI to analyze load, voltage, and network distribution data, to help “operators assess available capacity on the system and plan for future needs.” 105 AI allowed the distribution system operator to employ existing and new resources to make the distribution of energy assets more readily available and flexible. The International Energy Agency has proposed that energy efficiency is core to the reform of energy systems and will play a key role in reducing the growth of global energy demand to one-third of the current level by 2040.

AI as a building block to promote development in geoscience

The Earth’s system is of significant scientific interest, and affects all aspects of life. 106 The challenges, problems, and promising directions provided by AI are definitely not exhaustive, but rather, serve to illustrate that there is great potential for future AI research in this important field. Prosperity, development, and popularization of AI approaches in the geosciences is commonly driven by a posed scientific question, and the best way to succeed is that AI researchers work closely with geoscientists at all stages of research. That is because the geoscientists can better understand which scientific question is important and novel, which sample collection process can reasonably exhibit the inherent strengths, which datasets and parameters can be used to answer that question, and which pre-processing operations are conducted, such as removing seasonal cycles or smoothing. Similarly, AI researchers are better suited to decide which data analysis approaches are appropriate and available for the data, the advantages and disadvantages of these approaches, and what the approaches actually acquire. Interpretability is also an important goal in geoscience because, if we can understand the basic reasoning behind the models, patterns, or relationships extracted from the data, they can be used as building blocks in scientific knowledge discovery. Hence, frequent communication between the researchers avoids long detours and ensures that analysis results are indeed beneficial to both geoscientists and AI researchers.

AI in the life sciences

The developments of AI and the life sciences are intertwined. The ultimate goal of AI is to achieve human-like intelligence, as the human brain is capable of multi-tasking, learning with minimal supervision, and generalizing learned skills, all accomplished with high efficiency and low energy cost. 107

Mutual inspiration between AI and neuroscience

In the past decades, neuroscience concepts have been introduced into ML algorithms and played critical roles in triggering several important advances in AI. For example, the origins of DL methods lie directly in neuroscience, 5 which further stimulated the emergence of the field of RL. 108 The current state-of-the-art CNNs incorporate several hallmarks of neural computation, including nonlinear transduction, divisive normalization, and maximum-based pooling of inputs, 109 which were directly inspired by the unique processing of visual input in the mammalian visual cortex. 110 By introducing the brain's attentional mechanisms, a novel network has been shown to produce enhanced accuracy and computational efficiency at difficult multi-object recognition tasks than conventional CNNs. 111 Other neuroscience findings, including the mechanisms underlying working memory, episodic memory, and neural plasticity, have inspired the development of AI algorithms that address several challenges in deep networks. 108 These algorithms can be directly implemented in the design and refinement of the brain-machine interface and neuroprostheses.

On the other hand, insights from AI research have the potential to offer new perspectives on the basics of intelligence in the brains of humans and other species. Unlike traditional neuroscientists, AI researchers can formalize the concepts of neural mechanisms in a quantitative language to extract their necessity and sufficiency for intelligent behavior. An important illustration of such exchange is the development of the temporal-difference (TD) methods in RL models and the resemblance of TD-form learning in the brain. 112 Therefore, the China Brain Project covers both basic research on cognition and translational research for brain disease and brain-inspired intelligence technology. 113

AI for omics big data analysis

Currently, AI can perform better than humans in some well-defined tasks, such as omics data analysis and smart agriculture. In the big data era, 114 there are many types of data (variety), the volume of data is big, and the generation of data (velocity) is fast. The high variety, big volume, and fast velocity of data makes having it a matter of big value, but also makes it difficult to analyze the data. Unlike traditional statistics-based methods, AI can easily handle big data and reveal hidden associations.

In genetics studies, there are many successful applications of AI. 115 One of the key questions is to determine whether a single amino acid polymorphism is deleterious. 116 There have been sequence conservation-based SIFT 117 and network-based SySAP, 118 but all these methods have met bottlenecks and cannot be further improved. Sundaram et al. developed PrimateAI, which can predict the clinical outcome of mutation based on DNN. 119 Another problem is how to call copy-number variations, which play important roles in various cancers. 120 , 121 Glessner et al. proposed a DL-based tool DeepCNV, in which the area under the receiver operating characteristic (ROC) curve was 0.909, much higher than other ML methods. 122 In epigenetic studies, m6A modification is one of the most important mechanisms. 123 Zhang et al. developed an ensemble DL predictor (EDLm6APred) for mRNA m6A site prediction. 124 The area under the ROC curve of EDLm6APred was 86.6%, higher than existing m6A methylation site prediction models. There are many other DL-based omics tools, such as DeepCpG 125 for methylation, DeepPep 126 for proteomics, AtacWorks 127 for assay for transposase-accessible chromatin with high-throughput sequencing, and deepTCR 128 for T cell receptor sequencing.

Another emerging application is DL for single-cell sequencing data. Unlike bulk data, in which the sample size is usually much smaller than the number of features, the sample size of cells in single-cell data could also be big compared with the number of genes. That makes the DL algorithm applicable for most single-cell data. Since the single-cell data are sparse and have many unmeasured missing values, DeepImpute can accurately impute these missing values in the big gene × cell matrix. 129 During the quality control of single-cell data, it is important to remove the doublet solo embedded cells, using autoencoder, and then build a feedforward neural network to identify the doublet. 130 Potential energy underlying single-cell gradients used generative modeling to learn the underlying differentiation landscape from time series single-cell RNA sequencing data. 131

In protein structure prediction, the DL-based AIphaFold2 can accurately predict the 3D structures of 98.5% of human proteins, and will predict the structures of 130 million proteins of other organisms in the next few months. 132 It is even considered to be the second-largest breakthrough in life sciences after the human genome project 133 and will facilitate drug development among other things.

AI makes modern agriculture smart

Agriculture is entering a fourth revolution, termed agriculture 4.0 or smart agriculture, benefiting from the arrival of the big data era as well as the rapid progress of lots of advanced technologies, in particular ML, modern information, and communication technologies. 134 , 135 Applications of DL, information, and sensing technologies in agriculture cover the whole stages of agricultural production, including breeding, cultivation, and harvesting.

Traditional breeding usually exploits genetic variations by searching natural variation or artificial mutagenesis. However, it is hard for either method to expose the whole mutation spectrum. Using DL models trained on the existing variants, predictions can be made on multiple unidentified gene loci. 136 For example, an ML method, multi-criteria rice reproductive gene predictor, was developed and applied to predict coding and lincRNA genes associated with reproductive processes in rice. 137 Moreover, models trained in species with well-studied genomic data (such as Arabidopsis and rice) can also be applied to other species with limited genome information (such as wild strawberry and soybean). 138 In most cases, the links between genotypes and phenotypes are more complicated than we expected. One gene can usually respond to multiple phenotypes, and one trait is generally the product of the synergism between multi-genes and multi-development. For this reason, multi-traits DL models were developed and enabled genomic editing in plant breeding. 139 , 140

It is well known that dynamic and accurate monitoring of crops during the whole growth period is vitally important to precision agriculture. In the new stage of agriculture, both remote sensing and DL play indispensable roles. Specifically, remote sensing (including proximal sensing) could produce agricultural big data from ground, air-borne, to space-borne platforms, which have a unique potential to offer an economical approach for non-destructive, timely, objective, synoptic, long-term, and multi-scale information for crop monitoring and management, thereby greatly assisting in precision decisions regarding irrigation, nutrients, disease, pests, and yield. 141 , 142 DL makes it possible to simply, efficiently, and accurately discover knowledge from massive and complicated data, especially for remote sensing big data that are characterized with multiple spatial-temporal-spectral information, owing to its strong capability for feature representation and superiority in capturing the essential relation between observation data and agronomy parameters or crop traits. 135 , 143 Integration of DL and big data for agriculture has demonstrated the most disruptive force, as big as the green revolution. As shown in Figure 7 , for possible application a scenario of smart agriculture, multi-source satellite remote sensing data with various geo- and radio-metric information, as well as abundance of spectral information from UV, visible, and shortwave infrared to microwave regions, can be collected. In addition, advanced aircraft systems, such as unmanned aerial vehicles with multi/hyper-spectral cameras on board, and smartphone-based portable devices, will be used to obtain multi/hyper-spectral data in specific fields. All types of data can be integrated by DL-based fusion techniques for different purposes, and then shared for all users for cloud computing. On the cloud computing platform, different agriculture remote sensing models developed by a combination of data-driven ML methods and physical models, will be deployed and applied to acquire a range of biophysical and biochemical parameters of crops, which will be further analyzed by a decision-making and prediction system to obtain the current water/nutrient stress, growth status, and to predict future development. As a result, an automatic or interactive user service platform can be accessible to make the correct decisions for appropriate actions through an integrated irrigation and fertilization system.

Integration of AI and remote sensing in smart agriculture

Furthermore, DL presents unique advantages in specific agricultural applications, such as for dense scenes, that increase the difficulty of artificial planting and harvesting. It is reported that CNNs and Autoencoder models, trained with image data, are being used increasingly for phenotyping and yield estimation, 144 such as counting fruits in orchards, grain recognition and classification, disease diagnosis, etc. 145 , 146 , 147 Consequently, this may greatly liberate the labor force.

The application of DL in agriculture is just beginning. There are still many problems and challenges for the future development of DL technology. We believe, with the continuous acquisition of massive data and the optimization of algorithms, DL will have a better prospect in agricultural production.

AI in physics

The scale of modern physics ranges from the size of a neutron to the size of the Universe ( Figure 8 ). According to the scale, physics can be divided into four categories: particle physics on the scale of neutrons, nuclear physics on the scale of atoms, condensed matter physics on the scale of molecules, and cosmic physics on the scale of the Universe. AI, also called ML, plays an important role in all physics in different scales, since the use of the AI algorithm will be the main trend in data analyses, such as the reconstruction and analysis of images.

Scale of the physics

Speeding up simulations and identifications of particles with AI

There are many applications or explorations of applications of AI in particle physics. We cannot cover all of them here, but only use lattice quantum chromodynamics (LQCD) and the experiments on the Beijing spectrometer (BES) and the large hadron collider (LHC) to illustrate the power of ML in both theoretical and experimental particle physics.

LQCD studies the nonperturbative properties of QCD by using Monte Carlo simulations on supercomputers to help us understand the strong interaction that binds quarks together to form nucleons. Markov chain Monte Carlo simulations commonly used in LQCD suffer from topological freezing and critical slowing down as the simulations approach the real situation of the actual world. New algorithms with the help of DL are being proposed and tested to overcome those difficulties. 148 , 149 Physical observables are extracted from LQCD data, whose signal-to-noise ratio deteriorates exponentially. For non-Abelian gauge theories, such as QCD, complicated contour deformations can be optimized by using ML to reduce the variance of LQCD data. Proof-of-principle applications in two dimensions have been studied. 150 ML can also be used to reduce the time cost of generating LQCD data. 151

On the experimental side, particle identification (PID) plays an important role. Recently, a few PID algorithms on BES-III were developed, and the ANN 152 is one of them. Also, extreme gradient boosting has been used for multi-dimensional distribution reweighting, muon identification, and cluster reconstruction, and can improve the muon identification. U-Net is a convolutional network for pixel-level semantic segmentation, which is widely used in CV. It has been applied on BES-III to solve the problem of multi-turn curling track finding for the main drift chamber. The average efficiency and purity for the first turn's hits is about 91%, at the threshold of 0.85. Current (and future) particle physics experiments are producing a huge amount of data. Machine leaning can be used to discriminate between signal and overwhelming background events. Examples of data analyses on LHC, using supervised ML, can be found in a 2018 collaboration. 153 To take the potential advantage of quantum computers forward, quantum ML methods are also being investigated, see, for example, Wu et al., 154 and references therein, for proof-of-concept studies.

AI makes nuclear physics powerful

Cosmic ray muon tomography (Muography) 155 is an imaging graphe technology using natural cosmic ray muon radiation rather than artificial radiation to reduce the dangers. As an advantage, this technology can detect high-Z materials without destruction, as muon is sensitive to high-Z materials. The Classification Model Algorithm (CMA) algorithm is based on the classification in the supervised learning and gray system theory, and generates a binary classifier designing and decision function with the input of the muon track, and the output indicates whether the material exists at the location. The AI helps the user to improve the efficiency of the scanning time with muons.

AIso, for nuclear detection, the Cs 2 LiYCl 6 :Ce (CLYC) signal can react to both electrons and neutrons to create a pulse signal, and can therefore be applied to detect both neutrons and electrons, 156 but needs identification of the two particles by analyzing the shapes of the waves, that is n-γ ID. The traditional method has been the PSD (pulse shape discrimination) method, which is used to separate the waves of two particles by analyzing the distribution of the pulse information—such as amplitude, width, raise time, fall time, and the two particles that can be separated when the distribution has two separated Gaussian distributions. The traditional PSD can only analyze single-pulse waves, rather than multipulse waves, when two particles react with CLYC closely. But it can be solved by using an ANN method for classification of the six categories (n,γ,n + n,n + γ,γ + n,γ). Also, there are several parameters that could be used by AI to improve the reconstruction algorithm with high efficiency and less error.

AI-aided condensed matter physics

AI opens up a new avenue for physical science, especially when a trove of data is available. Recent works demonstrate that ML provides useful insights to improve the density functional theory (DFT), in which the single-electron picture of the Kohn-Sham scheme has the difficulty of taking care of the exchange and correlation effects of many-body systems. Yu et al. proposed a Bayesian optimization algorithm to fit the Hubbard U parameter, and the new method can find the optimal Hubbard U through a self-consistent process with good efficiency compared with the linear response method, 157 and boost the accuracy to the near-hybrid-functional-level. Snyder et al. developed an ML density functional for a 1D non-interacting non-spin-polarized fermion system to obtain significantly improved kinetic energy. This method enabled a direct approximation of the kinetic energy of a quantum system and can be utilized in orbital-free DFT modeling, and can even bypass the solving of the Kohn-Sham equation—while maintaining the precision to the quantum chemical level when a strong correlation term is included. Recently, FermiNet showed that the many-body quantum mechanics equations can be solved via AI. AI models also show advantages of capturing the interatom force field. In 2010, the Gaussian approximation potential (GAP) 158 was introduced as a powerful interatomic force field to describe the interactions between atoms. GAP uses kernel regression and invariant many-body representations, and performs quite well. For instance, it can simulate crystallization of amorphous crystals under high pressure fairly accurately. By employing the smooth overlap of the atomic position kernel (SOAP), 159 the accuracy of the potential can be further enhanced and, therefore, the SOAP-GAP can be viewed as a field-leading method for AI molecular dynamic simulation. There are also several other well-developed AI interatomic potentials out there, e.g., crystal graph CNNs provide a widely applicable way of vectorizing crystalline materials; SchNet embeds the continuous-filter convolutional layers into its DNNs for easing molecular dynamic as the potentials are space continuous; DimeNet constructs the directional message passing neural network by adding not only the bond length between atoms but also the bond angle, the dihedral angle, and the interactions between unconnected atoms into the model to obtain good accuracy.

AI helps explore the Universe

AI is one of the newest technologies, while astronomy is one of the oldest sciences. When the two meet, new opportunities for scientific breakthroughs are often triggered. Observations and data analysis play a central role in astronomy. The amount of data collected by modern telescopes has reached unprecedented levels, even the most basic task of constructing a catalog has become challenging with traditional source-finding tools. 160 Astronomers have developed automated and intelligent source-finding tools based on DL, which not only offer significant advantages in operational speed but also facilitate a comprehensive understanding of the Universe by identifying particular forms of objects that cannot be detected by traditional software and visual inspection. 160 , 161

More than a decade ago, a citizen science project called “Galaxy Zoo” was proposed to help label one million images of galaxies collected by the Sloan Digital Sky Survey (SDSS) by posting images online and recruiting volunteers. 162 Larger optical telescopes, in operation or under construction, produce data several orders of magnitude higher than SDSS. Even with volunteers involved, there is no way to analyze the vast amount of data received. The advantages of ML are not limited to source-finding and galaxy classification. In fact, it has a much wider range of applications. For example, CNN plays an important role in detecting and decoding gravitational wave signals in real time, reconstructing all parameters within 2 ms, while traditional algorithms take several days to accomplish the same task. 163 Such DL systems have also been used to automatically generate alerts for transients and track asteroids and other fast-moving near-Earth objects, improving detection efficiency by several orders of magnitude. In addition, astrophysicists are exploring the use of neural networks to measure galaxy clusters and study the evolution of the Universe.

In addition to the amazing speed, neural networks seem to have a deeper understanding of the data than expected and can recognize more complex patterns, indicating that the “machine” is evolving rather than just learning the characteristics of the input data.

AI in chemistry

Chemistry plays an important “central” role in other sciences 164 because it is the investigation of the structure and properties of matter, and identifies the chemical reactions that convert substances into to other substances. Accordingly, chemistry is a data-rich branch of science containing complex information resulting from centuries of experiments and, more recently, decades of computational analysis. This vast treasure trove of data is most apparent within the Chemical Abstract Services, which has collected more than 183 million unique organic and inorganic substances, including alloys, coordination compounds, minerals, mixtures, polymers, and salts, and is expanding by addition of thousands of additional new substances daily. 165 The unlimited complexity in the variety of material compounds explains why chemistry research is still a labor-intensive task. The level of complexity and vast amounts of data within chemistry provides a prime opportunity to achieve significant breakthroughs with the application of AI. First, the type of molecules that can be constructed from atoms are almost unlimited, which leads to unlimited chemical space 166 ; the interconnection of these molecules with all possible combinations of factors, such as temperature, substrates, and solvents, are overwhelmingly large, giving rise to unlimited reaction space. 167 Exploration of the unlimited chemical space and reaction space, and navigating to the optimum ones with the desired properties, is thus practically impossible solely from human efforts. Secondly, in chemistry, the huge assortment of molecules and the interplay of them with the external environments brings a new level of complexity, which cannot be simply predicted using physical laws. While many concepts, rules, and theories have been generalized from centuries of experience from studying trivial (i.e., single component) systems, nontrivial complexities are more likely as we discover that “more is different” in the words of Philip Warren Anderson, American physicist and Nobel Laureate. 168 Nontrivial complexities will occur when the scale changes, and the breaking of symmetry in larger, increasingly complex systems, and the rules will shift from quantitative to qualitative. Due to lack of systematic and analytical theory toward the structures, properties, and transformations of macroscopic substances, chemistry research is thus, incorrectly, guided by heuristics and fragmental rules accumulated over the previous centuries, yielding progress that only proceeds through trial and error. ML will recognize patterns from large amounts of data; thereby offering an unprecedented way of dealing with complexity, and reshaping chemistry research by revolutionizing the way in which data are used. Every sub-field of chemistry, currently, has utilized some form of AI, including tools for chemistry research and data generation, such as analytical chemistry and computational chemistry, as well as application to organic chemistry, catalysis, and medical chemistry, which we discuss herein.

AI breaks the limitations of manual feature selection methods

In analytical chemistry, the extraction of information has traditionally relied heavily on the feature selection techniques, which are based on prior human experiences. Unfortunately, this approach is inefficient, incomplete, and often biased. Automated data analysis based on AI will break the limitations of manual variable selection methods by learning from large amounts of data. Feature selection through DL algorithms enables information extraction from the datasets in NMR, chromatography, spectroscopy, and other analytical tools, 169 thereby improving the model prediction accuracy for analysis. These ML approaches will greatly accelerate the analysis of materials, leading to the rapid discovery of new molecules or materials. Raman scattering, for instance, since its discovery in the 1920s, has been widely employed as a powerful vibrational spectroscopy technology, capable of providing vibrational fingerprints intrinsic to analytes, thus enabling identification of molecules. 170 Recently, ML methods have been trained to recognize features in Raman (or SERS) spectra for the identity of an analyte by applying DL networks, including ANN, CNN, and fully convolutional network for feature engineering. 171 For example, Leong et al. designed a machine-learning-driven “SERS taster” to simultaneously harness useful vibrational information from multiple receptors for enhanced multiplex profiling of five wine flavor molecules at ppm levels. Principal-component analysis is employed for the discrimination of alcohols with varying degrees of substitution, and supported with vector machine discriminant analysis, is used to quantitatively classify all flavors with 100% accuracy. 172 Overall, AI techniques provide the first glimmer of hope for a universal method for spectral data analysis, which is fast, accurate, objective and definitive and with attractive advantages in a wide range of applications.

AI improves the accuracy and efficiency for various levels of computational theory

Complementary to analytical tools, computational chemistry has proven a powerful approach for using simulations to understand chemical properties; however, it is faced with an accuracy-versus-efficiency dilemma. This dilemma greatly limits the application of computational chemistry to real-world chemistry problems. To overcome this dilemma, ML and other AI methods are being applied to improve the accuracy and efficiency for various levels of theory used to describe the effects arising at different time and length scales, in the multi-scaling of chemical reactions. 173 Many of the open challenges in computational chemistry can be solved by ML approaches, for example, solving Schrödinger's equation, 174 developing atomistic 175 or coarse graining 176 potentials, constructing reaction coordinates, 177 developing reaction kinetics models, 178 and identifying key descriptors for computable properties. 179 In addition to analytical chemistry and computational chemistry, several disciplines of chemistry have incorporated AI technology to chemical problems. We discuss the areas of organic chemistry, catalysis, and medical chemistry as examples of where ML has made a significant impact. Many examples exist in literature for other subfields of chemistry and AI will continue to demonstrate breakthroughs in a wide range of chemical applications.

AI enables robotics capable of automating the synthesis of molecules

Organic chemistry studies the structure, property, and reaction of carbon-based molecules. The complexity of the chemical and reaction space, for a given property, presents an unlimited number of potential molecules that can be synthesized by chemists. Further complications are added when faced with the problems of how to synthesize a particular molecule, given that the process relies much on heuristics and laborious testing. Challenges have been addressed by researchers using AI. Given enough data, any properties of interest of a molecule can be predicted by mapping the molecular structure to the corresponding property using supervised learning, without resorting to physical laws. In addition to known molecules, new molecules can be designed by sampling the chemical space 180 using methods, such as autoencoders and CNNs, with the molecules coded as sequences or graphs. Retrosynthesis, the planning of synthetic routes, which was once considered an art, has now become much simpler with the help of ML algorithms. The Chemetica system, 181 for instance, is now capable of autonomous planning of synthetic routes that are subsequently proven to work in the laboratory. Once target molecules and the route of synthesis are determined, suitable reaction conditions can be predicted or optimized using ML techniques. 182

The integration of these AI-based approaches with robotics has enabled fully AI-guided robotics capable of automating the synthesis of small organic molecules without human intervention Figure 9 . 183 , 184

A closed loop workflow to enable automatic and intelligent design, synthesis, and assay of molecules in organic chemistry by AI

AI helps to search through vast catalyst design spaces

Catalytic chemistry originates from catalyst technologies in the chemical industry for efficient and sustainable production of chemicals and fuels. Thus far, it is still a challenging endeavor to make novel heterogeneous catalysts with good performance (i.e., stable, active, and selective) because a catalyst's performance depends on many properties: composition, support, surface termination, particle size, particle morphology, atomic coordination environment, porous structure, and reactor during the reaction. The inherent complexity of catalysis makes discovering and developing catalysts with desired properties more dependent on intuition and experiment, which is costly and time consuming. AI technologies, such as ML, when combined with experimental and in silico high-throughput screening of combinatorial catalyst libraries, can aid catalyst discovery by helping to search through vast design spaces. With a well-defined structure and standardized data, including reaction results and in situ characterization results, the complex association between catalytic structure and catalytic performance will be revealed by AI. 185 , 186 An accurate descriptor of the effect of molecules, molecular aggregation states, and molecular transport, on catalysts, could also be predicted. With this approach, researchers can build virtual laboratories to develop new catalysts and catalytic processes.

AI enables screening of chemicals in toxicology with minimum ethical concerns

A more complicated sub-field of chemistry is medical chemistry, which is a challenging field due to the complex interactions between the exotic substances and the inherent chemistry within a living system. Toxicology, for instance, as a broad field, seeks to predict and eliminate substances (e.g., pharmaceuticals, natural products, food products, and environmental substances), which may cause harm to a living organism. Living organisms are already complex, nearly any known substance can cause toxicity at a high enough exposure because of the already inherent complexity within living organisms. Moreover, toxicity is dependent on an array of other factors, including organism size, species, age, sex, genetics, diet, combination with other chemicals, overall health, and/or environmental context. Given the scale and complexity of toxicity problems, AI is likely to be the only realistic approach to meet regulatory body requirements for screening, prioritization, and risk assessment of chemicals (including mixtures), therefore revolutionizing the landscape in toxicology. 187 In summary, AI is turning chemistry from a labor-intensive branch of science to a highly intelligent, standardized, and automated field, and much more can be achieved compared with the limitation of human labor. Underlying knowledge with new concepts, rules, and theories is expected to advance with the application of AI algorithms. A large portion of new chemistry knowledge leading to significant breakthroughs is expected to be generated from AI-based chemistry research in the decades to come.

Conclusions

This paper carries out a comprehensive survey on the development and application of AI across a broad range of fundamental sciences, including information science, mathematics, medical science, materials science, geoscience, life science, physics, and chemistry. Despite the fact that AI has been pervasively used in a wide range of applications, there still exist ML security risks on data and ML models as attack targets during both training and execution phases. Firstly, since the performance of an ML system is highly dependent on the data used to train it, these input data are crucial for the security of the ML system. For instance, adversarial example attacks 188 providing malicious input data often lead the ML system into making false judgments (predictions or categorizations) with small perturbations that are imperceptible to humans; data poisoning by intentionally manipulating raw, training, or testing data can result in a decrease in model accuracy or lead to other error-specific attack purposes. Secondly, ML model attacks include backdoor attacks on DL, CNN, and federated learning that manipulate the model's parameters directly, as well as model stealing attack, model inversion attack, and membership inference attack, which can steal the model parameters or leak the sensitive training data. While a number of defense techniques against these security threats have been proposed, new attack models that target ML systems are constantly emerging. Thus, it is necessary to address the problem of ML security and develop robust ML systems that remain effective under malicious attacks.

Due to the data-driven character of the ML method, features of the training and testing data must be drawn from the same distribution, which is difficult to guarantee in practice. This is because, in practical application, the data source might be different from that in the training dataset. In addition, the data feature distribution may drift over time, which leads to a decline of the performance of the model. Moreover, if the model is trained with only new data, it will lead to catastrophic “forgetting” of the model, which means the model only remembers the new features and forgets the previously learned features. To solve this problem, more and more scholars pay attention on how to make the model have the ability of lifelong learning, that is, a change in the computing paradigm from “offline learning + online reasoning” to “online continuous learning,” and thus give the model have the ability of lifelong learning, just like a human being.

Acknowledgments

This work was partially supported by the National Key R&D Program of China (2018YFA0404603, 2019YFA0704900, 2020YFC1807000, and 2020YFB1313700), the Youth Innovation Promotion Association CAS (2011225, 2012006, 2013002, 2015316, 2016275, 2017017, 2017086, 2017120, 2017204, 2017300, 2017399, 2018356, 2020111, 2020179, Y201664, Y201822, and Y201911), NSFC (nos. 11971466, 12075253, 52173241, and 61902376), the Foundation of State Key Laboratory of Particle Detection and Electronics (SKLPDE-ZZ-201902), the Program of Science & Technology Service Network of CAS (KFJ-STS-QYZX-050), the Fundamental Science Center of the National Nature Science Foundation of China (nos. 52088101 and 11971466), the Scientific Instrument Developing Project of CAS (ZDKYYQ20210003), the Strategic Priority Research Program (B) of CAS (XDB33000000), the National Science Foundation of Fujian Province for Distinguished Young Scholars (2019J06023), the Key Research Program of Frontier Sciences, CAS (nos. ZDBS-LY-7022 and ZDBS-LY-DQC012), the CAS Project for Young Scientists in Basic Research (no. YSBR-005). The study is dedicated to the 10th anniversary of the Youth Innovation Promotion Association of the Chinese Academy of Sciences.

Author contributions

Y.X., Q.W., Z.A., Fei W., C.L., Z.C., J.M.T., and J.Z. conceived and designed the research. Z.A., Q.W., Fei W., Libo.Z., Y.W., F.D., and C.W.-Q. wrote the “ AI in information science ” section. Xin.L. wrote the “ AI in mathematics ” section. J.Q., K.H., W.S., J.W., H.X., Y.H., and X.C. wrote the “ AI in medical science ” section. E.L., C.F., Z.Y., and M.L. wrote the “ AI in materials science ” section. Fang W., R.R., S.D., M.V., and F.K. wrote the “ AI in geoscience ” section. C.H., Z.Z., L.Z., T.Z., J.D., J.Y., L.L., M.L., and T.H. wrote the “ AI in life sciences ” section. Z.L., S.Q., and T.A. wrote the “ AI in physics ” section. X.L., B.Z., X.H., S.C., X.L., W.Z., and J.P.L. wrote the “ AI in chemistry ” section. Y.X., Q.W., and Z.A. wrote the “Abstract,” “ introduction ,” “ history of AI ,” and “ conclusions ” sections.

Declaration of interests

The authors declare no competing interests.

Published Online: October 28, 2021

• Introduction
• Conclusions
• Article Information

eFigure 1. Large Language Model Integration

eFigure 2. Mock User Interface

eTable 1. Application of RE-AIM/PRISM for Evaluation of Implementation

eTable 2. Other Action Inclusions and Exclusions

eFigure 3. Time Metric Definitions

eFigure 4. Pre- and Postsurvey Questionnaire

eFigure 5. Clinician Recruitment Flowchart

eFigure 6. Histogram of Draft Utilization per Clinician With Pareto

eFigure 7. Draft Utilization vs Reply Action Count per Clinician

eTable 3. Draft Availability for All Unique Messages Viewed, Acted on or Replied to

eFigure 8. Average Time Spent per Clinician on Actions in Prepilot vs Pilot Periods

eFigure 9. Average Time Spent on Actions in Prepilot vs Pilot Periods Using a Linear Mixed Effects Model

eTable 4​. Impact of Draft Messages on Change in Log-Transformed Time Spent, Analyzed by Linear Mixed Effects Models

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• AI-Drafted Responses to Patients Reduced Clinician Burnout JAMA Medical News in Brief May 7, 2024 Emily Harris

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Garcia P , Ma SP , Shah S, et al. Artificial Intelligence–Generated Draft Replies to Patient Inbox Messages. JAMA Netw Open. 2024;7(3):e243201. doi:10.1001/jamanetworkopen.2024.3201

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Artificial Intelligence–Generated Draft Replies to Patient Inbox Messages

• 1 Department of Medicine, Stanford University School of Medicine, Stanford, California
• 2 Stanford Healthcare AI Applied Research Team, Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, California
• 3 Department of Family Medicine, University of California San Diego School of Medicine, La Jolla
• 4 Technology and Digital Solutions, Stanford Medicine, Stanford, California
• 5 Nursing Informatics & Innovation, Stanford Healthcare, Stanford, California
• 6 WellMD Center, Stanford University School of Medicine, Stanford, California
• Medical News in Brief AI-Drafted Responses to Patients Reduced Clinician Burnout Emily Harris JAMA

Question   What is the adoption of and clinician experience with clinical practice deployment of a large language model used to draft responses to patient inbox messages?

Findings   In this 5-week, single-group, quality improvement study of 162 clinicians, the mean draft utilization rate was 20%, there were statistically significant reductions in burden and burnout score derivatives, and there was no change in time.

Meaning   These findings suggest that the use of large language models in clinical workflows was spontaneously adopted, usable, and associated with improvement in clinician well-being.

Importance   The emergence and promise of generative artificial intelligence (AI) represent a turning point for health care. Rigorous evaluation of generative AI deployment in clinical practice is needed to inform strategic decision-making.

Objective   To evaluate the implementation of a large language model used to draft responses to patient messages in the electronic inbox.

Design, Setting, and Participants   A 5-week, prospective, single-group quality improvement study was conducted from July 10 through August 13, 2023, at a single academic medical center (Stanford Health Care). All attending physicians, advanced practice practitioners, clinic nurses, and clinical pharmacists from the Divisions of Primary Care and Gastroenterology and Hepatology were enrolled in the pilot.

Intervention   Draft replies to patient portal messages generated by a Health Insurance Portability and Accountability Act–compliant electronic health record–integrated large language model.

Main Outcomes and Measures   The primary outcome was AI-generated draft reply utilization as a percentage of total patient message replies. Secondary outcomes included changes in time measures and clinician experience as assessed by survey.

Results   A total of 197 clinicians were enrolled in the pilot; 35 clinicians who were prepilot beta users, out of office, or not tied to a specific ambulatory clinic were excluded, leaving 162 clinicians included in the analysis. The survey analysis cohort consisted of 73 participants (45.1%) who completed both the presurvey and postsurvey. In gastroenterology and hepatology, there were 58 physicians and APPs and 10 nurses. In primary care, there were 83 physicians and APPs, 4 nurses, and 8 clinical pharmacists. The mean AI-generated draft response utilization rate across clinicians was 20%. There was no change in reply action time, write time, or read time between the prepilot and pilot periods. There were statistically significant reductions in the 4-item physician task load score derivative (mean [SD], 61.31 [17.23] presurvey vs 47.26 [17.11] postsurvey; paired difference, −13.87; 95% CI, −17.38 to −9.50; P  < .001) and work exhaustion scores (mean [SD], 1.95 [0.79] presurvey vs 1.62 [0.68] postsurvey; paired difference, −0.33; 95% CI, −0.50 to −0.17; P  < .001).

Conclusions and Relevance   In this quality improvement study of an early implementation of generative AI, there was notable adoption, usability, and improvement in assessments of burden and burnout. There was no improvement in time. Further code-to-bedside testing is needed to guide future development and organizational strategy.

The emergence and ubiquity of generative artificial intelligence (AI) represents a turning point for health care. As organizations consider how to approach this new technology, several questions must be answered: How can the highest value and lowest risk use cases be identified? How should clinical practice deployments be structured to determine value? When is the right time to invest in widespread adoption of these technologies? As organizations grapple with how to integrate and implement AI technologies in a fair, useful, and reliable way, 1 rigorous evaluation of clinical practice generative AI deployment is needed to inform strategic decision-making.

One potentially high-value use case for large language models is to help address patient portal messaging, which has seen a 157% increase during the COVID-19 pandemic compared with prepandemic levels. 2 - 4 This rapidly growing modality for care has strained health system capacity and become a leading factor in clinician burnout. 2 , 3 Although several strategies have been proposed for inbox management, including automated message categorization and triage, team optimization, and billing for patient messages, 5 - 7 more effective solutions are required.

Large language models, like generative pretrained transformer 4 (GPT-4; OpenAI), 8 have shown the ability to draft empathetic responses to online patient questions 9 and to assist with medical knowledge tasks. 10 A novel Health Insurance Portability and Accountability Act–compliant, electronic health record (EHR)–integrated version of this tool was created to generate draft replies to patient portal messages for clinicians but has not been assessed in clinical practice. 11 Therefore, this study evaluated the implementation of this novel technology using an evaluation guided by the Reach, Efficacy, Adoption, Implementation, Maintenance/Practical, Robust Implementation, and Sustainability Model (RE-AIM/PRISM). 12 - 14 The developmental assessment of readiness for adoption and clinician experience included a primary outcome of utilization, with secondary outcomes evaluating time, usability, utility, and impact on clinician well-being.

The Stanford University institutional review board office determined that this study met the criteria for quality improvement and was exempt from institutional review board–mandated consent. All clinicians who participated were directly contacted via email and were allowed to opt out of the pilot. Clinicians who completed the presurvey or postsurvey were compensated with a $20 gift card upon completion of the postsurvey. Standards for Quality Improvement Reporting Excellence ( SQUIRE ) reporting guidelines for quality improvement studies were followed.

Stanford Medicine routed select patient messages upon arrival to the inbox messaging pool to EHR developer Epic (Epic Systems) for categorization via GPT-3.5 Turbo (selected by EPIC to minimize cost and compute) and GPT-4 for draft reply generation (eFigure 1 in Supplement 1 ). Messages written in a non-English language, with an attachment, or sent by a proxy were excluded. Messages were categorized into 1 of 4 categories (general, results, medications, and paperwork), which triggered a corresponding prompt that included the patient message, selected structured data elements (eg, name, age, department, allergies, and so forth) and the last clinic note. Patient messages and draft replies were displayed within the EHR with options to start with draft or start blank reply (eFigure 2 in Supplement 1 ). Technical reliability was tested with 14 ambulatory clinician beta users before study initiation. Education was provided via email and brief presentations at clinician group meetings.

This prospective quality improvement study was conducted from July to August 2023 at a single academic medical center (Stanford Health Care). All attending physicians, advanced practice practitioners (APPs), clinical nurses, and clinical pharmacists from the Division of Primary Care and the Division of Gastroenterology and Hepatology were invited to participate. The pilot period lasted for 35 days extending from July 10 through August 13, 2023. A corresponding 35-day prepilot period extending from May 29 through July 2, 2023, was used for comparison.

The RE-AIM/PRISM framework was used to evaluate the implementation from the perspective of clinicians (eTable 1 in Supplement 1 ). For utilization, view was defined as any time a patient message was viewed by a pilot clinician; other action as any action taken by a pilot clinician directly linked to the message other than a reply (eTable 2 in Supplement 1 ); reply action as instances where pilot clinicians clicked start with draft, start blank reply, or reply to patient; and draft used as instances where pilot clinicians clicked start with draft. Patient messages that were not viewed by a pilot clinician and actions not linked to a message were not included in the analyses (eFigure 1 in Supplement 1 ).

For the time analysis, other action time was defined by the time between when the user last viewed the message and when the action on the message was initiated. Read time was measured as the time between when the user last viewed the message and when the user clicked start with draft, start blank reply, or reply to patient. Write time was measured as the time between when the user clicked start with draft, start blank reply, or reply to patient and when the reply was sent. Reply action time was defined by the time between when the user last viewed the message and when the message was sent. All times were measured in seconds using audit log data (eFigure 3 in Supplement 1 ). Outliers above 3000 seconds (0.1% of other action times, 1.23% of read times, and 0.26% of write times) were excluded.

Presurveys and postsurveys were distributed to all clinicians via email. Specialty and role were captured for all pilot users with additional demographic data captured for survey respondents. EHR burden was evaluated using an adapted NASA Task Load Index score with a 4-item physician task load score derivative. 15 - 17 Physician task load scores range from 0 to 100, with lower scores indicating less cognitive task load. Burnout was evaluated using the 4-item questionnaire evaluating work exhaustion from the Stanford Professional Fulfillment Index (PFI-WE). Work exhaustion scores range from 0 to 4, with lower scores indicating lower levels of work exhaustion. 18 , 19 Satisfaction was assessed via net promoter score, which is calculated by categorizing likelihood to recommend responses into promoters (score 9-10), passives (score 7-8), and detractors (score 0-6) and then subtracting the percentage of detractors from the percentage of promoters. The net promoter score ranges from –100 to 100, with higher scores indicating higher levels of satisfaction. 20 Usability was assessed with questions regarding perceived utility, quality, and time. Likert scale scores for utility, quality, and time range from 1 to 5, with lower scores indicating a higher level of agreement on a 5-point Likert scale. The text of all survey questions is available in eFigure 4 in Supplement 1 .

Free-text survey comments were analyzed to assess clinician perspectives. Comments were parsed into phrases to allow for granular analysis. A comprehensive code book, rooted in RE-AIM/PRISM, was developed to guide the systematic analysis. Both deductive and inductive codes were included. Two qualitative researchers (M.S. and A.D.S.) independently coded phrases using the deductive code book followed by consensus reconciliation. During consensus coding, inductive codes were introduced to capture emerging themes. Phrases were allowed to have multiple codes, and each code was assigned a positive, negative, or neutral connotation. Counts of codes in each category, as well as the distribution of sentiments (positive, negative, and neutral), were aggregated and summarized.

Clinician demographics were described with counts and proportions. A χ 2 test was used to compare the distribution of specialties and roles in the overall cohort compared with the survey cohort, with statistical significance considered at P  < .05.

Counts for reply actions, reply actions with draft available, and drafts used were aggregated at the level of individual clinicians for the pilot period. Draft utilization for each clinician was calculated as the count of drafts used by that clinician divided by the number of reply actions with drafts available. Summary statistics were calculated as means and SDs. To assess for significant between-group differences in draft utilization, the Kruskal-Wallis test was used, with P  < .05 considered statistically significant. Counts and proportions for draft availability were calculated for views, actions, and replies in the pilot period. For replies, counts and proportions were also calculated for message exclusions and error types.

The mean other action time, reply action time, read time, and write time was calculated for each clinician in both the prepilot and pilot periods. For those with at least 1 action in both periods, the change in mean other action time was calculated. For those with at least 1 reply in both periods, the change in mean reply action time, read time, and write time was also calculated. All measures were summarized as means and SDs. One-sample t tests were used to compare the observed differences against a null hypothesis of no change between the prepilot and pilot periods. P < .05 was considered statistically significant. To account for repeated measures and heterogeneity across clinicians, analysis was also performed using linear mixed effects models. The intervention period (ie, prepilot vs pilot) was considered as a fixed effect with clinicians incorporated as random effects with both a random intercept and random slope. A logarithmic transform was applied to time measures before fitting the model. P < .05 was considered significant.

The analysis of survey responses used the Wilcoxon signed-rank test, and statistical significance was considered for 2-sided P  < .05. Analysis was performed using the statsmodels package in Python programing language version 3.11.4 (Python Software Foundation), with the exception of the survey data, which were analyzed using Minitab Statistical Software version 21.4.2.0 (Minitab, LLC). Prespecified subgroups included specialties and roles.

Of the 197 clinicians enrolled in the pilot, 162 were included in the study analysis. Clinicians who were in the prepilot (14 clinicians), out of office (16 clinicians), or not working in a specific ambulatory clinic (4 triage nurses and 1 procedural nurse) were excluded (eFigure 5 in Supplement 1 ). The survey group consisted of 73 participants (45.1%) who completed both the presurvey and postsurvey.

In gastroenterology and hepatology, there were 58 physicians and APPs and 10 nurses. In primary care, there were 83 physicians and APPs, 4 nurses, and 8 clinical pharmacists ( Table 1 ). There was no statistically significant difference in the distribution of specialties and roles between the overall cohort and the survey cohort (χ 2 4  = 7.96; P  = .09). Additional demographics for the survey group, including age, years in practice since training, gender, and number of half-days of clinic per week, are also shown.

The overall mean utilization rate per clinician was 20% ( Table 2 ), with significant between-group differences in utilization ( k  = 10.8; P  = .03 by Kruskal-Wallis test). For gastroenterology and hepatology, nurses had the highest utilization at 29%, whereas clinical pharmacists had the highest utilization for primary care at 44%. High SDs reflect substantial within-group variability in both reply counts and draft utilization, confirmed on visualization of the behaviors of individual clinicians (eFigures 6 and 7 in Supplement 1 ).

Of the 12 844 messages for which replies were sent to patients, 9621 (75%) had a draft available (eTable 3 in Supplement 1 ). Of the 3223 (25%) messages for which a draft was not available, 2596 (20%) were due to exclusion criteria and 627 (5%) were due to technical limitations such as insufficient compute and token limits.

The mean (SD) change in time spent between the prepilot and pilot periods was not significant for other action time (1.3 [27.6] seconds), reply action time (11.8 [104.6] seconds), read time (6.7 [85.6] seconds), or write time (5.1 [70.2] seconds). Clinicians who performed at least 1 action (161 clinicians) or 1 reply (138 clinicians) in the prepilot and pilot periods were included in the analysis. There were notable differences in time parameters on subgroup analyses ( Table 3 ). On visualization of individual clinicians, there was significant within-group heterogeneity, although clinicians with higher reply counts fall closer to the diagonal, suggesting that at least part of the variation was random (eFigure 8 in Supplement 1 ).

To account for repeated measures and the observed heterogeneity, a similar analysis was performed comparing the same time measures in the prepilot and pilot periods using linear mixed effects models (eFigure 9 in Supplement 1 ). No significant change in time spent was identified as a result of the intervention (eTable 4 in Supplement 1 ).

Table 4 delineates the pivotal components from the presurvey and postsurvey results. Statistically significant reductions in 4-item physician task load score derivative (mean [SD], 61.31 [17.23] presurvey vs 47.26 [17.11] postsurvey; paired difference, −13.87; 95% CI, −17.38 to −9.50; P  < .001) and work exhaustion scores (PFI-WE) (mean [SD], 1.95 [0.79] presurvey vs 1.62 [0.68] postsurvey; paired difference, −0.33; 95% CI, −0.50 to −0.17; P  < .001) were found overall. When stratified by specialty, similar reductions in physician task load and work exhaustion were seen for both primary care (task load, mean [SD], 58.72 [14.64] presurvey vs 47.72 [18.15] postsurvey; paired difference, −10.99; 95% CI, −15.00 to −5.50; P < .001; work exhaustion, mean [SD], 1.96 [0.65] presurvey vs 1.64 [0.64] postsurvey; paired difference, −0.33; 95% CI, −0.50 to −0.42; P = .009) and gastroenterology and hepatology (task load, mean [SD], 64.39 [19.50] presurvey vs 46.63 [15.27] postsurvey; paired difference, −17.76; 95% CI, −26.38 to −11.25; P  < .001; work exhaustion, mean [SD], 1.93 [0.93] presurvey vs 1.60 [0.74] postsurvey; paired difference, −0.31; 95% CI, −0.50 to −0.13; P  < .001). Clinicians overall expressed optimism about utility and ability to save time before the pilot, and these positive perceptions remained largely unchanged afterward (mean [SD] score, 2.15 [0.85] presurvey vs 2.17 [0.99] postsurvey for utility; 2.23 [0.82] presurvey vs 2.29 [1.20] postsurvey for time-saving). In primary care, there were modest expectations about message quality that improved at the end of the pilot (mean [SD] score, 2.73 [0.98] presurvey vs 2.23 [1.12] postsurvey; paired difference, −0.43; 95% CI, −1.00 to −0.00; P = .04). Net promoter scores were favorable among primary care physicians and APPs (score, 13), primary care clinical pharmacists (score, 71), and gastroenterology and hepatology nurses (score, 50), but unfavorable among primary care nurses (score, −60) and gastroenterology and hepatology physicians and APPs (score, −19).

Table 5 showcases themes, representative quotations, and sentiments for the qualitative encoding of free-text survey comments. Comments about draft message voice and/or tone were the most common and included the highest absolute number of negative comments (10 positive, 2 neutral, and 14 negative). The second most common theme was about future use and included the highest absolute and relative number of positive comments (18 positive and 1 negative). The most negative relative comments were about draft message length and/or brevity (1 positive, 2 neutral, and 8 negative). Facilitators for adoption include readiness for future use, utility (13 positive, 2 neutral, and 4 negative), and time-saving (12 positive and 1 negative). Barriers to adoption include draft message voice and/or tone, content relevance (8 positive, 1 neutral, and 9 negative), and accuracy (4 positive and 5 negative).

Although generative AI may ultimately transform the practice of medicine and help address challenges in care delivery, it is important to ground organizational strategy in clinical practice data about outcomes and value. In one of the earliest implementations of generative AI in clinical practice, this quality improvement study evaluated the adoption, usability, and utility of AI-generated draft replies to patient messages. The mean cumulative draft utilization after only 5 weeks was 20%. This is remarkable given that (1) these versions of GPT were not trained on medical literature or fine-tuned for this task specifically, (2) limited context was available from the patient’s EHR for draft generation, and (3) minimal user education was necessary for adoption.

Improvements in task load and emotional exhaustion scores suggest that generated draft replies have the potential to impact cognitive burden and burnout. Similarly, users expressed high expectations about utility, quality, and time that were either met or exceeded at the end of the pilot. Given the evidence that burnout is associated with turnover, reductions in clinical activity, and quality, even a modest improvement may have a substantial impact. 21 - 24

Despite improvements in burden and burnout, no changes in overall reply time, read time, or write time were found when comparing prepilot and pilot periods. It may be that switching from writing to editing may be less cognitively taxing despite taking the same amount of time. That said, survey respondents showed optimism about time saved, suggesting that perceptions of time may be different from time captured via EHR metadata, both of which may be different than real time. Finally, although future iterations may focus on measurable time-savings, considering other relevant outcomes including volume of follow-up messages and patient experience will provide a more complete picture.

Subgroup analysis showed that gastroenterology and hepatology nurses had higher draft utilization, a trend toward time saved, and positive net promoter scores. This finding suggests that the value of future generative AI tools may vary according to specific practice patterns and workflows. Understanding this fit is necessary to optimize use, especially in cases where tools are expensive or require substantial training. In addition to between-group heterogeneity, there was also significant within-group heterogeneity for adoption and time spent. These findings were supported by the qualitative analysis of free-text feedback where, for example, some individuals preferred longer, more empathetic responses but others preferred shorter, more formal responses.

Given the rapid evolution of generative AI, these shortcomings represent opportunities for further research and development. Personalization can be addressed at the vendor level (eg, embedded tools to control brevity and tone) or at the system level (fine-tuning on data specific to an institution or individuals). Additional enhancements may also lead to improved performance, including increased access to patient information to inform draft generation, optimized categorization leading to better response specificity, and the development of large language models trained and/or fine-tuned on medical literature and EHR data.

Finally, it is worth considering the need for reference standards. Although there has been early work done to identify benchmarks for training sets for EHR data, 25 there is no reference standard for patient message replies either from a clinician or patient perspective. As generative AI technologies evolve, identifying reference standards and developing training sets to fine-tune models and evaluate model performance for specific use cases will be essential.

This was a single-group prospective study at a single institution, which limits the generalizability of results. Although there were 162 participants in the primary analyses and 73 survey respondents in the supplemental analyses, they were limited to 2 departments and 4 types of clinicians. Given the observed between-group and within-group heterogeneity, the study may have been insufficiently powered to identify subgroup differences. Regarding cognitive burden and burnout outcomes, novelty bias and the Hawthorne effect may have skewed toward positive results. Regarding time, there are known limitations to the use of EHR metadata to approximate time, 26 which underscores the need to develop standardized time calculations and definitions. Future controlled trials at multiple sites with a focus on understanding what might be mediating the changes identified in this study are warranted.

In this quality improvement study of generative AI in health care, using GPT-4 to generate draft responses to patient messages, we found adoption, usability, and notable improvements in mental task load and work exhaustion. There were no adverse safety signals, and qualitative feedback suggested high expectations for future use. These findings are especially remarkable given minimal user education and the use of a large language model without domain-specific training. That said, we did not find time-savings, and feedback highlighted the need for improvements in tone, brevity and personalization. Ongoing code-to-bedside testing is needed to inform future development and strategic organizational decision-making. In the case of generated draft messages, there is a cost each time GPT-4 is used to generate a draft response; multiplying that cost by millions of patient messages could represent a substantial expense to the US health care delivery system that must be justified with clinical practice data. Although the transformative potential of generative AI is evident, understanding when these tools have reached a maturity level to warrant costly investments and widespread use is paramount.

Accepted for Publication: January 26, 2024.

Published: March 20, 2024. doi:10.1001/jamanetworkopen.2024.3201

Open Access: This is an open access article distributed under the terms of the CC-BY License . © 2024 Garcia P et al. JAMA Network Open .

Corresponding Authors: Patricia Garcia, MD, Department of Medicine, Stanford University School of Medicine, 430 Broadway St, 3rd Floor, Redwood City, CA 94063 ( [email protected] ); Stephen P. Ma, MD, PhD, Department of Medicine, Stanford University School of Medicine, 453 Quarry Road, MC 5660, Palo Alto, CA 94304 ( [email protected] ).

Author Contributions: Drs Garcia and Ma had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Garcia and Ma contributed equally to this work and share co–first authorship.

Concept and design: Garcia, Ma, Shah, Smith, Tai-Seale, Takazawa, Clutter, Vogt, Rojo, Lin, Shanafelt, Pfeffer, Sharp.

Acquisition, analysis, or interpretation of data: Garcia, Ma, Shah, Smith, Jeong, Devon-Sand, Clutter, Vogt, Lugtu, Shanafelt, Sharp.

Drafting of the manuscript: Garcia, Ma, Shah, Smith, Takazawa, Vogt, Rojo, Sharp.

Critical review of the manuscript for important intellectual content: Garcia, Ma, Smith, Jeong, Devon-Sand, Tai-Seale, Clutter, Vogt, Lugtu, Lin, Shanafelt, Pfeffer, Sharp.

Statistical analysis: Garcia, Ma, Smith, Jeong, Devon-Sand, Clutter, Vogt.

Obtained funding: Pfeffer.

Administrative, technical, or material support: Garcia, Shah, Smith, Jeong, Tai-Seale, Takazawa, Clutter, Vogt, Lugtu, Rojo, Pfeffer, Sharp.

Supervision: Garcia, Smith, Vogt, Lin, Pfeffer, Sharp.

Conflict of Interest Disclosures: Ms Smith reported receiving grants from Google, Omada Health, and PredictaMed outside the submitted work. Dr Shanafelt reported having a patent for Well-being Index Instruments and Mayo Leadership Impact Index, with royalties paid from Mayo Clinic, and receiving honoraria for presenting grand rounds and keynote lectures and advising health care organizations on clinician well-being. No other disclosures were reported.

Data Sharing Statement: See Supplement 2 .

Additional Contributions: We thank the following groups for their contributions to this article: Stanford Technology and Digital Solutions Teams; Stanford Department of Medicine, Division of Primary Care; Stanford Department of Medicine, Division of Gastroenterology and Hepatology; Microsoft; and Epic Systems. Cole Armstrong, BS (Grant Street Group), Matthew Wiese, BS (Epic Systems), Wyatt Harrison, BS (Epic Systems), and Shashank Raghu, MS (Epic Systems), provided invaluable technical and data expertise. They were not compensated for this work.

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