topics for research in chemistry

100+ Great Chemistry Research Topics

Table of contents

• 1 5 Tips for Writing Chemistry Research Papers
• 2 Chemical Engineering Research Topics
• 3 Organic Сhemistry Research Topics
• 4 Іnorganic Сhemistry Research Topics
• 5 Biomolecular Сhemistry Research Topics
• 6 Analytical Chemistry Research Topics
• 7 Computational Chemistry Research Topics
• 8 Physical Chemistry Research Topics
• 9 Innovative Chemistry Research Topics
• 10 Environmental Chemistry Research Topics
• 11 Green Chemistry Research Topics
• 12.1 Conclusion

Do you need a topic for your chemistry research paper? Are you unsure of where to start? Don’t worry – we’re here to help. In this post, we’ll go over a series of the best chemistry research paper topics as well as Tips for Writing Chemistry Research Papers on different topics. By the time you finish reading this post, you’ll have plenty of ideas to get started on your next research project!

There are many different subfields of chemistry, so it can be tough to find interesting chemistry topics to write about. If you’re struggling to narrow down your topic, we’ll go over lists of topics in multiple fields of study.

Doing research is important to help scientists learn more about the world around us. By researching different compounds and elements, we can learn more about how they interact with one another and how they can be used to create new products or improve existing ones.

There are many different topics that you can choose to research in chemistry. Here are just a few examples:

• The history of chemistry and how it has evolved over time
• How different chemicals react with one another
• How to create new compounds or improve existing ones
• The role of chemistry in the environment
• The health effects of different chemicals

5 Tips for Writing Chemistry Research Papers

Once you have chosen a topic for your research paper , it is important to follow some tips to ensure that your paper is well-written and accurate. Here are a few tips to get you started:

• Start by doing some background research on your topic. This will help you understand the basics of the topic and give you a good foundation to build your paper on.
• Make sure to cite all of the sources that you use in your paper. This will help to show where you got your information and will also help to add credibility to your work.
• Be sure to proofread your paper before you submit it. This will ensure that there are no errors and that your paper is clear and concise.
• Get help from a tutor or friend if you are struggling with your paper. They may be able to offer helpful advice or feedback.
• Take your time when writing your research paper. This is not a race, and it is important to make sure that you do a good job on your research.

By following these tips, you can be sure that your chemistry research paper will be a success! So what are you waiting for? Let’s go over some of the best research paper topics out there. Choosing a chemistry research topic is just the first step. The complexity of scientific writing can be daunting. For those who need assistance, a professional research paper writer can help you craft a well-researched and clearly articulated paper.

Chemical Engineering Research Topics

Chemical Engineering is a branch of engineering that deals with the design and application of chemical processes. If you’re wondering how to choose a paper topic, here are some ideas to inspire you:

• How to create new alloy compounds or improve existing ones
• The health effects of the food industry chemicals
• Chemical engineering and sustainable development
• The future of chemical engineering
• Chemical engineering and the food industry
• Chemical engineering and the pharmaceutical industry
• Chemical engineering and the cosmetics industry
• Chemical engineering and the petrochemical industry
• Biocompatible materials for drug delivery systems
• Membrane technology in water treatment
• Development of synthetic fibers for industrial use

These are just a few examples – there are many more possibilities out there! So get started on your research today. Who knows what you might discover!

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Organic Сhemistry Research Topics

Organic chemistry is the study of carbon-containing molecules. There are many different organic chemistry research topics that a student could choose to focus on and here are just a few examples of possible research projects in organic chemistry:

• Investigating new methods for synthesizing chiral molecules
• Studying the structure and reactivity of carbon nanotubes
• Investigating metal complexes with organometallic ligands
• Designing benzene derivatives with improved thermal stability
• Exploring new ways to control the stereochemistry of chemical reactions
• Studying the role of enzymes in organic synthesis
• Investigating new strategies for combating drug resistance
• Developing new methods for detecting explosives residues
• Studying the photochemistry of organic molecules
• Studying the behavior of organometallic compounds in biological systems
• Synthetic routes for biodegradable plastics
• Catalysis in organic synthesis
• Development of non-toxic solvents

Іnorganic Сhemistry Research Topics

Inorganic Chemistry is the study of the chemistry of materials that do not contain carbon. Unlike other chemistry research topics, these include elements such as metals, minerals, and inorganic compounds. If you are looking for inorganic chemistry research topics on inorganic chemistry, here are some ideas to get you started:

• How different metals react with one another
• How to create new alloys or improve existing ones
• The role of inorganic chemistry in the environment
• Rare earth elements and their applications in electronics
• Inorganic polymers in construction materials
• Photoluminescent materials for energy conversion
• Inorganic chemistry and sustainable development
• The future of inorganic chemistry
• Inorganic chemistry and the food industry
• Inorganic chemistry and the pharmaceutical industry
• Atomic structure progressive scale grading
• Inorganiс Сhemistry and the cosmetics industry

Biomolecular Сhemistry Research Topics

Biomolecular chemistry is the study of molecules that are important for life. These molecules can be found in all living things, from tiny bacteria to the largest animals. Researchers who work in this field use a variety of techniques to learn more about how these molecules function and how they interact with each other.

If you are looking for essential biomolecular chemistry research topics, here are some ideas to get you started:

• The structure and function of DNA
• Lipidomics and its applications in disease diagnostics
• The structure and function of proteins
• The role of carbohydrates in the body
• The role of lipids in the body
• How enzymes work
• Protein engineering for therapeutic applications
• The role of biochemistry in heart disease
• Cyanides and their effect on the body
• The role of biochemistry in cancer treatment
• The role of biochemistry in Parkison’s disease treatment
• The role of biochemistry in the immune system
• Carbohydrate-based vaccines

The possibilities are endless for someone willing to dedicate some time to research.

Analytical Chemistry Research Topics

Analytical Chemistry is a type of chemistry that helps scientists figure out what something is made of. This can be done through a variety of methods, such as spectroscopy or chromatography. If you are looking for research topics, here are some ideas to get you started:

• How food chemicals react with one another
• Mass spectrometry
• Microplastics detection in marine environments
• Development of sensors for heavy metal detection in water
• Analytical aspects of gas and liquid chromatography
• Analytical chemistry and sustainable development
• Atomic absorption spectroscopy methods and best practices
• Analytical chemistry and the pharmaceutical industry in Ibuprofen consumption
• Analytical chemistry and the cosmetics industry in UV protectors
• High-throughput screening methods in pharmaceutical analysis
• Dispersive X-ray analysis of damaged tissues

Analytical chemistry is considered by many a complex science and there is a lot yet to be discovered in the field.

Computational Chemistry Research Topics

Computational chemistry is a way to use computers to help chemists understand chemical reactions. This can be done by simulating reactions or by designing new molecules. If you are looking for essential chemistry research topics in computational chemistry, here are some ideas to get you started:

• Molecular mechanics simulation
• Machine learning applications in predicting molecular properties
• Reaction rates of complex chemical reactions
• Designing new molecules: how can simulation help
• The role of computers in the study of quantum mechanics
• How to use computers to predict chemical reactions
• Using computers to understand organic chemistry
• The future of computational Chemistry in organic reactions
• The impacts of simulation on the development of new medications
• Combustion reaction simulation impact on engine development
• Quantum-chemistry simulation review
• Simulation of protein folding and misfolding in diseases
• Development of algorithms for chemical synthesis planning
• Applications of Metal-Organic Frameworks in water sequestration and catalysis

Computers are cutting-edge technology in chemical research and this relatively new field of study has a ton yet to be explored.

Physical Chemistry Research Topics

Physical chemistry is the study of how matter behaves. It looks at the physical and chemical properties of atoms and molecules and how they interact with each other. If you are looking for physical chemistry research topics, here are some ideas to get you started:

• Standardization of pH scales
• Structure of atom on a quantum scale
• Bonding across atoms and molecules
• The effect of temperature on chemical reactions
• The role of light in in-body chemical reactions
• Chemical kinetics
• Molecular dynamics in confined spaces
• Quantum computing for solving chemical problems
• Studies on non-Newtonian fluids in industrial processes
• Surface tension and its effects on mixtures
• The role of pressure in chemical reactions
• Rates of diffusion in gases and liquids
• The role of entropy in chemical reactions

Here are just a few samples, but there are plenty more options! Start your research right now!

Innovative Chemistry Research Topics

Innovative chemistry is all about coming up with new ideas and ways to do things. This can be anything from creating new materials to finding new ways to make existing products. If you are looking for ground-breaking chemistry research topics, here are some ideas to get you started:

• Amino acids side chain effects in protein folding
• Chemistry in the production of nanomaterials
• The role of enzymes in chemical reactions
• Photocatalysis in 3D printing
• Avoiding pesticides in agriculture
• Combining chemical and biological processes
• Gene modification in medicinal chemistry
• The role of quantum mechanics in chemical reactions
• Astrochemical research on extraterrestrial molecules
• Spectroscopy signatures of pressurized organic components
• Development of smart materials with responsive properties
• Chemistry in space: studying chemical reactions in microgravity
• Utilization of CO2 in chemical synthesis
• Use of black soldier fly carcasses for bioplastic production using extracted chitin
• Bioorthogonal chemistry for molecule synthesis inside living systems

If you need a hand, there are several sites that also offer research papers for sale and can be a great asset as you work to create your own research papers.

Whatever route you decide to take, good luck! And remember – the sky’s the limit when it comes to research! So get started today and see where your studies may take you. Who knows, you might just make a breakthrough discovery!

Environmental Chemistry Research Topics

Environmental Chemistry is the study of how chemicals interact with the environment. This can include anything from the air we breathe to the water we drink. If you are looking for environmental chemistry research topics, here are some ideas to get you started:

• Plastic effects on ocean life
• Urban ecology
• The role of carbon in climate change
• Air pollution and its effects
• Water pollution and its effects
• Chemicals in food and their effect on the body
• The effect of chemicals on plant life
• Earth temperature prediction models
• Effects of pharmaceuticals in aquatic environments
• Atmospheric chemistry and urban air quality
• Bioremediation techniques for oil spill cleanup
• Regulatory and environmental impact of Per- and Polyfluoroalkyl (PFA) substances
• Comparison of chemical regulation impacts like PFA with historical cases such as lead in fuel

A lot of research on the environment is being conducted at the moment because the environment is in danger. There are a lot of environmental problems that need to be solved, and research is the key to solving them.

Green Chemistry Research Topics

Green chemistry is the study of how to make products and processes that are environmentally friendly. This can include anything from finding new ways to recycle materials to developing new products that are biodegradable. If you are looking for green chemistry research topics, here are some ideas to get you started:

• Recycling and reuse of materials
• Developing biodegradable materials
• Improving existing recycling processes
• Green chemistry and sustainable development
• The future of green chemistry
• Green chemistry and the food industry
• Lifecycle assessment of chemical processes
• Green chemistry and the pharmaceutical industry
• Development of catalysts for green chemistry
• Green chemistry and the cosmetics industry
• Alternative energy sources for chemical synthesis

A more environmentally friendly world is something we all aspire for and a lot of research has been conducted on how we can achieve this, making this one of the most promising areas of study. The results have been varied, but there are a few key things we can do to make a difference.

Controversial Chemistry Research Topics

Controversial chemistry is all about hot-button topics that people are passionate about. This can include anything from the use of chemicals in warfare to the health effects of different chemicals. If you are looking for controversial topics to write about , here are some ideas to get you started:

• The use of chemicals in warfare
• Gene modification in human babies
• Bioengineering
• How fast food chemicals affect the human brain
• The role of the government in regulating chemicals
• Evolution of cigarette chemicals over time
• Chemical effects of CBD oils
• Ethical issues in genetic modification of organisms
• Nuclear energy: risks and benefits
• Use of chemicals in electronic waste recycling
• Antidepressant chemical reactions
• Synthetic molecule replication methods
• Gene analysis

Controversial research papers often appear in the media before it has been peer-reviewed and published in a scientific journal. The reason for this is that the media is interested in stories that are new, exciting, and generate a lot of debate.

Chemistry is an incredibly diverse and interesting field, with many controversial topics to write about. If you are looking for a research topic, consider the examples listed in this article. With a little bit of effort, you are sure to find a topic that is both interesting and within your skillset.

In order to be a good researcher, it is important to be able to think critically and solve problems. However, innovation in chemistry research can be challenging. When thinking about how to innovate, it is important to consider both the practical and theoretical aspects of your research. Additionally, try to build on the work of others in order to create something new and unique. With a little bit of effort, you are sure to be able to find a topic that is both interesting and within your skillset.

Happy writing!

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Home » 300+ Chemistry Research Topics

300+ Chemistry Research Topics

Table of Contents

Chemistry is a fascinating and complex field that explores the composition, properties, and behavior of matter at the molecular and atomic level. As a result, there are numerous chemistry research topics that can be explored, ranging from the development of new materials and drugs to the study of natural compounds and the environment. In this rapidly evolving field, researchers are constantly uncovering new insights and pushing the boundaries of our understanding of chemistry. Whether you are a student, a professional researcher, or simply curious about the world around you, there is always something new to discover in the field of chemistry. In this post, we will explore some of the exciting and important research topics in chemistry today.

Chemistry Research Topics

Chemistry Research Topics are as follows:

Organic Chemistry Research Topics

Organic Chemistry Research Topics are as follows:

• Development of novel synthetic routes for the production of biologically active natural products
• Investigation of reaction mechanisms and kinetics for organic transformations
• Design and synthesis of new catalysts for asymmetric organic reactions
• Synthesis and characterization of chiral compounds for pharmaceutical applications
• Development of sustainable methods for the synthesis of organic molecules using renewable resources
• Discovery of new reaction pathways for the conversion of biomass into high-value chemicals
• Study of molecular recognition and host-guest interactions for drug design
• Design and synthesis of new materials for energy storage and conversion
• Development of efficient and selective methods for C-H functionalization reactions
• Exploration of the reactivity of reactive intermediates such as radicals and carbenes
• Study of supramolecular chemistry and self-assembly of organic molecules
• Development of new methods for the synthesis of heterocyclic compounds
• Investigation of the biological activities and mechanisms of action of natural products
• Synthesis of polymeric materials with controlled architecture and functionality
• Development of new synthetic methodologies for the preparation of bioconjugates
• Investigation of the mechanisms of enzyme catalysis and the design of enzyme inhibitors
• Synthesis and characterization of novel fluorescent probes for biological imaging
• Development of new synthetic strategies for the preparation of carbohydrates and glycoconjugates
• Study of the properties and reactivity of carbon nanomaterials
• Design and synthesis of novel drugs for the treatment of diseases such as cancer, diabetes, and Alzheimer’s disease.

Inorganic Chemistry Research Topics

Inorganic Chemistry Research Topics are as follows:

• Synthesis and characterization of new metal-organic frameworks (MOFs) for gas storage and separation applications
• Development of new catalysts for sustainable chemical synthesis reactions
• Investigation of the electronic and magnetic properties of transition metal complexes for spintronics applications
• Synthesis and characterization of novel nanomaterials for energy storage applications
• Development of new ligands for metal coordination complexes with potential medical applications
• Investigation of the mechanism of metal-catalyzed reactions using advanced spectroscopic techniques
• Synthesis and characterization of new inorganic materials for photocatalytic water splitting
• Development of new materials for electrochemical carbon dioxide reduction reactions
• Investigation of the properties of transition metal oxides for energy storage and conversion applications
• Synthesis and characterization of new metal chalcogenides for optoelectronic applications
• Development of new methods for the preparation of inorganic nanoparticles with controlled size and shape
• Investigation of the reactivity and catalytic properties of metal clusters
• Synthesis and characterization of new metal-organic polyhedra (MOPs) for gas storage and separation applications
• Development of new methods for the synthesis of metal nanoparticles using environmentally friendly reducing agents
• Investigation of the properties of metal-organic frameworks for gas sensing applications
• Synthesis and characterization of new coordination polymers with potential magnetic and electronic properties
• Development of new materials for electrocatalytic water oxidation reactions
• Investigation of the properties of metal-organic frameworks for carbon capture and storage applications
• Synthesis and characterization of new metal-containing polymers with potential applications in electronics and energy storage
• Development of new methods for the synthesis of metal-organic frameworks using green solvents and renewable resources.

Physical Chemistry Research Topics

Physical Chemistry Research Topics are as follows:

• Investigation of the properties and interactions of ionic liquids in aqueous and non-aqueous solutions.
• Development of advanced analytical techniques for the study of protein structure and dynamics.
• Investigation of the thermodynamic properties of supercritical fluids for use in industrial applications.
• Development of novel nanomaterials for energy storage applications.
• Studies of the surface chemistry of catalysts for the optimization of their performance in chemical reactions.
• Development of new methods for the synthesis of complex organic molecules with improved yields and selectivity.
• Investigation of the molecular mechanisms involved in the catalysis of biochemical reactions.
• Development of new strategies for the controlled release of drugs and other bioactive molecules.
• Studies of the interaction of nanoparticles with biological systems for biomedical applications.
• Investigation of the thermodynamic properties of materials under extreme conditions of temperature and pressure.
• Development of new methods for the characterization of materials at the nanoscale.
• Investigation of the electronic and magnetic properties of materials for use in spintronics.
• Development of new materials for energy conversion and storage.
• Studies of the kinetics and thermodynamics of adsorption processes on surfaces.
• Investigation of the transport properties of ionic liquids for use in energy storage and conversion devices.
• Development of new materials for the capture and sequestration of greenhouse gases.
• Studies of the structure and properties of biomolecules for use in drug design and development.
• Investigation of the dynamics of chemical reactions in solution using time-resolved spectroscopic techniques.
• Development of new approaches for the synthesis of metallic and semiconductor nanoparticles with controlled size and shape.
• Studies of the structure and properties of materials for use in electrochemical energy storage devices.

Analytical Chemistry Research Topics

Analytical Chemistry Research Topics are as follows:

• Development and optimization of analytical techniques for the quantification of trace elements in food and environmental samples.
• Design and synthesis of novel analytical probes for the detection of biomolecules in complex matrices.
• Investigation of the fundamental mechanisms involved in the separation and detection of complex mixtures using chromatographic techniques.
• Development of sensors and biosensors for the detection of chemical and biological species in real-time.
• Investigation of the chemical and structural properties of nanomaterials and their applications in analytical chemistry.
• Development and validation of analytical methods for the quantification of contaminants and pollutants in water, air, and soil.
• Investigation of the molecular mechanisms underlying drug metabolism and toxicity using mass spectrometry.
• Development of analytical tools for the identification and quantification of drugs of abuse in biological matrices.
• Investigation of the chemical composition and properties of natural products and their applications in medicine and food science.
• Development of advanced analytical techniques for the characterization of proteins and peptides.
• Investigation of the chemistry and mechanism of action of antioxidants in foods and their impact on human health.
• Development of analytical methods for the detection and quantification of microorganisms in food and environmental samples.
• Investigation of the molecular mechanisms involved in the biosynthesis and degradation of important biomolecules such as proteins, carbohydrates, and lipids.
• Development of analytical methods for the detection and quantification of environmental toxins and their impact on human health.
• Investigation of the structure and properties of biological membranes and their role in drug delivery and disease.
• Development of analytical techniques for the characterization of complex mixtures such as petroleum and crude oil.
• Investigation of the chemistry and mechanism of action of natural and synthetic dyes.
• Development of analytical techniques for the detection and quantification of pharmaceuticals and personal care products in water and wastewater.
• Investigation of the chemical composition and properties of biopolymers and their applications in biomedicine and biomaterials.
• Development of analytical methods for the identification and quantification of essential nutrients and vitamins in food and dietary supplements.

Biochemistry Research Topics

Biochemistry Research Topics are as follows:

• The role of enzymes in metabolic pathways
• The biochemistry of DNA replication and repair
• Protein folding and misfolding diseases
• Lipid metabolism and the pathogenesis of atherosclerosis
• The role of vitamins and minerals in human metabolism
• Biochemistry of cancer and the development of targeted therapies
• The biochemistry of signal transduction pathways and their regulation
• The mechanisms of antibiotic resistance in bacteria
• The biochemistry of neurotransmitters and their roles in behavior and disease
• The role of oxidative stress in aging and age-related diseases
• The biochemistry of microbial fermentation and its applications in industry
• The biochemistry of the immune system and its response to pathogens
• The biochemistry of plant metabolism and its regulation
• The molecular basis of genetic diseases and gene therapy
• The biochemistry of membrane transport and its role in cell function
• The biochemistry of muscle contraction and its regulation
• The role of lipids in membrane structure and function
• The biochemistry of photosynthesis and its regulation
• The biochemistry of RNA splicing and alternative splicing events
• The biochemistry of epigenetics and its regulation in gene expression.

Environmental Chemistry Research Topics

Environmental Chemistry Research Topics are as follows:

• Investigating the effects of microplastics on aquatic ecosystems and their potential impact on human health.
• Examining the impact of climate change on soil quality and nutrient availability in agricultural systems.
• Developing methods to improve the removal of heavy metals from contaminated soils and waterways.
• Assessing the effectiveness of natural and synthetic antioxidants in mitigating the effects of air pollution on human health.
• Investigating the potential for using algae and other microorganisms to sequester carbon dioxide from the atmosphere.
• Studying the role of biodegradable plastics in reducing plastic waste and their impact on the environment.
• Examining the impact of pesticides and other agricultural chemicals on water quality and the health of aquatic organisms.
• Investigating the effects of ocean acidification on marine organisms and ecosystems.
• Developing new materials and technologies to reduce carbon emissions from industrial processes.
• Evaluating the effectiveness of phytoremediation in cleaning up contaminated soils and waterways.
• Studying the impact of microplastics on terrestrial ecosystems and their potential to enter the food chain.
• Developing sustainable methods for managing and recycling electronic waste.
• Investigating the role of natural processes, such as weathering and erosion, in regulating atmospheric carbon dioxide levels.
• Assessing the impact of urbanization on air quality and developing strategies to mitigate pollution in cities.
• Examining the effects of climate change on the distribution and abundance of species in different ecosystems.
• Investigating the impact of ocean currents on the distribution of pollutants and other environmental contaminants.
• Developing new materials and technologies for renewable energy generation and storage.
• Studying the effects of deforestation on soil quality, water availability, and biodiversity.
• Assessing the potential for using waste materials, such as agricultural residues and municipal solid waste, as sources of renewable energy.
• Investigating the role of natural and synthetic chemicals in regulating ecosystem functions, such as nutrient cycling and carbon sequestration.

Polymer Chemistry Research Topics

Polymer Chemistry Research Topics are as follows:

• Development of new monomers for high-performance polymers
• Synthesis and characterization of biodegradable polymers for sustainable packaging
• Design of stimuli-responsive polymers for drug delivery applications
• Investigation of the properties and applications of conductive polymers
• Development of new catalysts for controlled/living polymerization
• Synthesis of polymers with tailored mechanical properties
• Characterization of the structure-property relationship in polymer nanocomposites
• Study of the impact of polymer architecture on material properties
• Design and synthesis of new polymeric materials for energy storage
• Development of high-throughput methods for polymer synthesis and characterization
• Exploration of new strategies for polymer recycling and upcycling
• Synthesis and characterization of responsive polymer networks for smart textiles
• Design of advanced polymer coatings with self-healing properties
• Investigation of the impact of processing conditions on the morphology and properties of polymer materials
• Study of the interactions between polymers and biological systems
• Development of biocompatible polymers for tissue engineering applications
• Synthesis and characterization of block copolymers for advanced membrane applications
• Exploration of the potential of polymer-based sensors and actuators
• Design of novel polymer electrolytes for advanced batteries and fuel cells
• Study of the behavior of polymers under extreme conditions, such as high pressure or temperature.

Materials Chemistry Research Topics

Materials Chemistry Research Topics are as follows:

• Development of new advanced materials for energy storage and conversion
• Synthesis and characterization of nanomaterials for environmental remediation
• Design and fabrication of stimuli-responsive materials for drug delivery
• Investigation of electrocatalytic materials for fuel cells and electrolysis
• Fabrication of flexible and stretchable electronic materials for wearable devices
• Development of novel materials for high-performance electronic devices
• Exploration of organic-inorganic hybrid materials for optoelectronic applications
• Study of corrosion-resistant coatings for metallic materials
• Investigation of biomaterials for tissue engineering and regenerative medicine
• Synthesis and characterization of metal-organic frameworks for gas storage and separation
• Design and fabrication of new materials for water purification
• Investigation of carbon-based materials for supercapacitors and batteries
• Synthesis and characterization of self-healing materials for structural applications
• Development of new materials for catalysis and chemical reactions
• Exploration of magnetic materials for spintronic devices
• Investigation of thermoelectric materials for energy conversion
• Study of 2D materials for electronic and optoelectronic applications
• Development of sustainable and eco-friendly materials for packaging
• Fabrication of advanced materials for sensors and actuators
• Investigation of materials for high-temperature applications such as aerospace and nuclear industries.

Nuclear Chemistry Research Topics

Nuclear Chemistry Research Topics are as follows:

• Nuclear fission and fusion reactions
• Nuclear power plant safety and radiation protection
• Radioactive waste management and disposal
• Nuclear fuel cycle and waste reprocessing
• Nuclear energy and its impact on climate change
• Radiation therapy for cancer treatment
• Radiopharmaceuticals for medical imaging
• Nuclear medicine and its role in diagnostics
• Nuclear forensics and nuclear security
• Isotopic analysis in environmental monitoring and pollution control
• Nuclear magnetic resonance (NMR) spectroscopy
• Nuclear magnetic resonance imaging (MRI)
• Radiation damage in materials and radiation effects on electronic devices
• Nuclear data evaluation and validation
• Nuclear reactors design and optimization
• Nuclear fuel performance and irradiation behavior
• Nuclear energy systems integration and optimization
• Neutron and gamma-ray detection and measurement techniques
• Nuclear astrophysics and cosmology
• Nuclear weapons proliferation and disarmament.

Medicinal Chemistry Research Topics

Medicinal Chemistry Research Topics are as follows:

• Drug discovery and development
• Design and synthesis of novel drugs
• Medicinal chemistry of natural products
• Structure-activity relationships (SAR) of drugs
• Rational drug design using computational methods
• Target identification and validation
• Drug metabolism and pharmacokinetics (DMPK)
• Drug delivery systems
• Development of new antibiotics
• Design of drugs for the treatment of cancer
• Development of drugs for the treatment of neurological disorders
• Medicinal chemistry of peptides and proteins
• Development of drugs for the treatment of infectious diseases
• Discovery of new antiviral agents
• Design of drugs for the treatment of cardiovascular diseases
• Medicinal chemistry of enzyme inhibitors
• Development of drugs for the treatment of inflammatory diseases
• Design of drugs for the treatment of metabolic disorders
• Medicinal chemistry of anti-cancer agents
• Development of drugs for the treatment of rare diseases.

Food Chemistry Research Topics

Food Chemistry Research Topics are as follows:

• Investigating the effect of cooking methods on the nutritional value of food.
• Analyzing the role of antioxidants in preventing food spoilage and degradation.
• Examining the effect of food processing techniques on the nutritional value of fruits and vegetables.
• Studying the chemistry of food additives and their impact on human health.
• Evaluating the role of enzymes in food digestion and processing.
• Investigating the chemical properties and functional uses of food proteins.
• Analyzing the effect of food packaging materials on the quality and safety of food products.
• Examining the chemistry of food flavorings and the impact of flavor on consumer acceptance.
• Studying the role of carbohydrates in food texture and structure.
• Investigating the chemistry of food lipids and their impact on human health.
• Analyzing the chemical properties and functional uses of food gums and emulsifiers.
• Examining the effect of processing on the flavor and aroma of food products.
• Studying the chemistry of food preservatives and their impact on food safety.
• Investigating the chemical properties and functional uses of food fibers.
• Analyzing the effect of food processing on the bioavailability of nutrients.
• Examining the chemistry of food colorants and their impact on consumer acceptance.
• Studying the role of vitamins and minerals in food and their impact on human health.
• Investigating the chemical properties and functional uses of food hydrocolloids.
• Analyzing the effect of food processing on the allergenicity of food products.
• Examining the chemistry of food sweeteners and their impact on human health.

Industrial Chemistry Research Topics

Industrial Chemistry Research Topics are as follows:

• Development of catalysts for selective hydrogenation reactions in the petrochemical industry.
• Green chemistry approaches for the synthesis of biodegradable polymers from renewable sources.
• Optimization of solvent extraction processes for the separation of rare earth elements from ores.
• Development of novel materials for energy storage applications, such as lithium-ion batteries.
• Production of biofuels from non-food sources, such as algae or waste biomass.
• Application of computational chemistry to optimize the design of new catalysts and materials.
• Design and optimization of continuous flow processes for large-scale chemical production.
• Development of new synthetic routes for the production of pharmaceutical intermediates.
• Investigation of the environmental impact of industrial processes and development of sustainable alternatives.
• Development of innovative water treatment technologies for industrial wastewater.
• Synthesis of functionalized nanoparticles for use in drug delivery and other biomedical applications.
• Optimization of processes for the production of high-performance polymers, such as polyamides or polyesters.
• Design and optimization of process control strategies for efficient and safe chemical production.
• Development of new methods for the detection and removal of heavy metal ions from industrial effluents.
• Investigation of the behavior of surfactants in complex mixtures, such as crude oil or food products.
• Development of new materials for catalytic oxidation reactions, such as the removal of volatile organic compounds from air.
• Investigation of the properties and behavior of materials under extreme conditions, such as high pressure or high temperature.
• Development of new processes for the production of chemicals from renewable resources, such as bio-based building blocks.
• Study of the kinetics and mechanism of chemical reactions in complex systems, such as multi-phase reactors.
• Optimization of the production of fine chemicals, such as flavors and fragrances, using biocatalytic processes.

Computational Chemistry Research Topics

Computational Chemistry Research Topics are as follows:

• Development and application of machine learning algorithms for predicting chemical reactions and properties.
• Investigation of the role of solvents in chemical reactions using molecular dynamics simulations.
• Modeling and simulation of protein-ligand interactions to aid drug design.
• Study of the electronic structure and reactivity of catalysts for sustainable energy production.
• Analysis of the thermodynamics and kinetics of complex chemical reactions using quantum chemistry methods.
• Exploration of the mechanism and kinetics of enzyme-catalyzed reactions using molecular dynamics simulations.
• Investigation of the properties and behavior of nanoparticles using computational modeling.
• Development of computational tools for the prediction of chemical toxicity and environmental impact.
• Study of the electronic properties of graphene and other 2D materials for applications in electronics and energy storage.
• Investigation of the mechanisms of protein folding and aggregation using molecular dynamics simulations.
• Development and optimization of computational methods for calculating thermodynamic properties of liquids and solids.
• Study of the properties of supercritical fluids for applications in separation and extraction processes.
• Development of new methods for the calculation of electron transfer rates in complex systems.
• Investigation of the electronic and mechanical properties of carbon nanotubes for applications in nanoelectronics and nanocomposites.
• Development of new approaches for modeling the interaction of biomolecules with biological membranes.
• Study of the mechanisms of charge transfer in molecular and hybrid solar cells.
• Analysis of the structural and mechanical properties of materials under extreme conditions using molecular dynamics simulations.
• Development of new approaches for the calculation of free energy differences in complex systems.
• Investigation of the reaction mechanisms of metalloenzymes using quantum mechanics/molecular mechanics (QM/MM) methods.
• Study of the properties of ionic liquids for applications in catalysis and energy storage.

Theoretical Chemistry Research Topics

Theoretical Chemistry Research Topics are as follows:

• Quantum Chemical Studies of Excited State Processes in Organic Molecules
• Theoretical Investigation of Structure and Reactivity of Metal-Organic Frameworks
• Computational Modeling of Reaction Mechanisms and Kinetics in Enzyme Catalysis
• Theoretical Investigation of Non-Covalent Interactions in Supramolecular Chemistry
• Quantum Chemical Studies of Photochemical Processes in Organic Molecules
• Theoretical Analysis of Charge Transport in Organic and Inorganic Materials
• Computational Modeling of Protein Folding and Dynamics
• Quantum Chemical Investigations of Electron Transfer Processes in Complex Systems
• Theoretical Studies of Surface Chemistry and Catalysis
• Computational Design of Novel Materials for Energy Storage Applications
• Theoretical Analysis of Chemical Bonding and Molecular Orbital Theory
• Quantum Chemical Investigations of Magnetic Properties of Complex Systems
• Computational Modeling of Biological Membranes and Transport Processes
• Theoretical Studies of Nonlinear Optical Properties of Molecules and Materials
• Quantum Chemical Studies of Spectroscopic Properties of Molecules
• Theoretical Investigations of Reaction Mechanisms in Organometallic Chemistry
• Computational Modeling of Heterogeneous Catalysis
• Quantum Chemical Studies of Excited State Dynamics in Photosynthesis
• Theoretical Analysis of Chemical Reaction Networks
• Computational Design of Nanomaterials for Biomedical Applications

Astrochemistry Research Topics

Astrochemistry Research Topics are as follows:

• Investigating the chemical composition of protoplanetary disks and its implications for planet formation
• Examining the role of magnetic fields in the formation of complex organic molecules in space
• Studying the effects of interstellar radiation on the chemical evolution of molecular clouds
• Exploring the chemistry of comets and asteroids to better understand the early solar system
• Investigating the origin and evolution of interstellar dust and its relationship to organic molecules
• Examining the formation and destruction of interstellar molecules in shocked gas
• Studying the chemical processes that occur in the atmospheres of planets and moons in our solar system
• Exploring the possibility of life on other planets through astrobiology and astrochemistry
• Investigating the chemistry of planetary nebulae and their role in the evolution of stars
• Studying the chemical properties of exoplanets and their potential habitability
• Examining the chemical reactions that occur in the interstellar medium
• Investigating the chemical composition of supernova remnants and their impact on the evolution of galaxies
• Studying the chemical composition of interstellar grains and their role in the formation of stars and planets
• Exploring the chemistry of astrocytes and their role in the evolution of galaxies
• Investigating the formation of interstellar ice and its implications for the origin of life
• Examining the chemistry of molecular clouds and its relationship to star formation
• Studying the chemical composition of the interstellar medium in different galaxies and how it varies
• Investigating the role of cosmic rays in the formation of complex organic molecules in space
• Exploring the chemical properties of interstellar filaments and their relationship to star formation
• Studying the chemistry of protostars and the role of turbulence in the formation of stars.

Geochemistry Research Topics

Geochemistry Research Topics are as follows:

• Understanding the role of mineralogical and geochemical factors on metal mobility in contaminated soils
• Investigating the sources and fate of dissolved organic matter in aquatic systems
• Exploring the geochemical signatures of ancient sedimentary rocks to reconstruct Earth’s past atmospheric conditions
• Studying the impacts of land-use change on soil organic matter content and quality
• Investigating the impact of acid mine drainage on water quality and ecosystem health
• Examining the processes controlling the behavior and fate of emerging contaminants in the environment
• Characterizing the organic matter composition of shale gas formations to better understand hydrocarbon storage and migration
• Evaluating the potential for carbon capture and storage in geologic formations
• Investigating the geochemical processes controlling the formation and evolution of ore deposits
• Studying the geochemistry of geothermal systems to better understand energy production potential and environmental impacts
• Exploring the impacts of climate change on the biogeochemistry of terrestrial ecosystems
• Investigating the geochemical cycling of nutrients in coastal marine environments
• Characterizing the isotopic composition of minerals and fluids to understand Earth’s evolution
• Developing new analytical techniques to better understand the chemistry of natural waters
• Studying the impact of anthropogenic activities on the geochemistry of urban soils
• Investigating the role of microbial processes in geochemical cycling of elements in soils and sediments
• Examining the impact of wildfires on soil and water chemistry
• Characterizing the geochemistry of mineral dust and its impact on climate and biogeochemical cycles
• Investigating the geochemical factors controlling the release and transport of contaminants from mine tailings
• Exploring the biogeochemistry of wetlands and their role in carbon sequestration and nutrient cycling.

Electrochemistry Research Topics

Electrochemistry Research Topics are as follows:

• Development of high-performance electrocatalysts for efficient electrochemical conversion of CO2 to fuels and chemicals
• Investigation of electrode-electrolyte interfaces in lithium-ion batteries for enhanced battery performance and durability
• Design and synthesis of novel electrolytes for high-energy-density and stable lithium-sulfur batteries
• Development of advanced electrochemical sensors for the detection of trace-levels of analytes in biological and environmental samples
• Analysis of the electrochemical behavior of new materials and their electrocatalytic properties in fuel cells
• Study of the kinetics of electrochemical reactions and their effect on the efficiency and selectivity of electrochemical processes
• Development of novel strategies for the electrochemical synthesis of value-added chemicals from biomass and waste materials
• Analysis of the electrochemical properties of metal-organic frameworks (MOFs) for energy storage and conversion applications
• Investigation of the electrochemical degradation mechanisms of polymer electrolyte membranes in fuel cells
• Study of the electrochemical properties of 2D materials and their applications in energy storage and conversion devices
• Development of efficient electrochemical systems for desalination and water treatment applications
• Investigation of the electrochemical properties of metal-oxide nanoparticles for energy storage and conversion applications
• Analysis of the electrochemical behavior of redox-active organic molecules and their application in energy storage and conversion devices
• Study of the electrochemical behavior of metal-organic frameworks (MOFs) for the catalytic conversion of CO2 to value-added chemicals
• Development of novel electrode materials for electrochemical capacitors with high energy density and fast charge/discharge rates
• Investigation of the electrochemical properties of perovskite materials for energy storage and conversion applications
• Study of the electrochemical behavior of enzymes and their application in bioelectrochemical systems
• Development of advanced electrochemical techniques for the characterization of interfacial processes in electrochemical systems
• Analysis of the electrochemical behavior of nanocarbons and their application in electrochemical energy storage devices
• Investigation of the electrochemical properties of ionic liquids for energy storage and conversion applications.

Surface Chemistry Research Topics

Surface Chemistry Research Topics are as follows:

• Surface modification of nanoparticles for enhanced catalytic activity
• Investigating the effect of surface roughness on the wetting behavior of materials
• Development of new materials for solar cell applications through surface chemistry techniques
• Surface chemistry of graphene and its applications in electronic devices
• Surface functionalization of biomaterials for biomedical applications
• Characterization of surface defects and their effect on material properties
• Surface modification of carbon nanotubes for energy storage applications
• Developing surface coatings for corrosion protection of metals
• Synthesis of self-assembled monolayers on surfaces for sensor applications
• Surface chemistry of metal-organic frameworks for gas storage and separation
• Investigating the role of surface charge in protein adsorption
• Developing surfaces with superhydrophobic or superoleophobic properties for self-cleaning applications
• Surface functionalization of nanoparticles for drug delivery applications
• Surface chemistry of semiconductors and its effect on photovoltaic properties
• Development of surface-enhanced Raman scattering (SERS) substrates for trace analyte detection
• Surface functionalization of graphene oxide for water purification applications
• Investigating the role of surface tension in emulsion formation and stabilization
• Surface modification of membranes for water desalination and purification
• Synthesis and characterization of metal nanoparticles for catalytic applications
• Development of surfaces with controlled wettability for microfluidic applications.

Atmospheric Chemistry Research Topics

Atmospheric Chemistry Research Topics are as follows:

• The impact of wildfires on atmospheric chemistry
• The role of aerosols in atmospheric chemistry
• The chemistry and physics of ozone depletion in the stratosphere
• The chemistry and dynamics of the upper atmosphere
• The impact of anthropogenic emissions on atmospheric chemistry
• The role of clouds in atmospheric chemistry
• The chemistry of atmospheric particulate matter
• The impact of nitrogen oxides on atmospheric chemistry and air quality
• The effects of climate change on atmospheric chemistry
• The impact of atmospheric chemistry on climate change
• The chemistry and physics of atmospheric mercury cycling
• The impact of volcanic eruptions on atmospheric chemistry
• The chemistry and physics of acid rain formation and effects
• The role of halogen chemistry in the atmosphere
• The chemistry of atmospheric radicals and their impact on air quality and health
• The impact of urbanization on atmospheric chemistry
• The chemistry and physics of stratospheric polar vortex dynamics
• The role of natural sources (e.g. ocean, plants) in atmospheric chemistry
• The impact of atmospheric chemistry on the biosphere
• The chemistry and dynamics of the ozone hole over Antarctica.

Photochemistry Research Topics

Photochemistry Research Topics are as follows:

• Investigating the mechanisms of photoinduced electron transfer reactions in organic photovoltaic materials.
• Developing novel photoredox catalysts for photochemical reactions.
• Understanding the effects of light on DNA and RNA stability and replication.
• Studying the photochemistry of atmospheric pollutants and their impact on air quality.
• Designing new photoresponsive materials for advanced photonic and electronic devices.
• Exploring the photochemistry of metalloporphyrins for potential applications in catalysis.
• Investigating the photochemistry of transition metal complexes and their use as photodynamic therapy agents.
• Developing new photocatalytic systems for sustainable energy production.
• Studying the photochemistry of natural products and their potential pharmaceutical applications.
• Investigating the role of light in the formation and degradation of environmental contaminants.
• Designing new photochromic materials for smart windows and displays.
• Exploring the photochemistry of carbon nanomaterials for energy storage and conversion.
• Developing new light-driven molecular machines for nanotechnology applications.
• Investigating the photochemistry of organic dyes for potential applications in dye-sensitized solar cells.
• Studying the effects of light on the behavior of biological macromolecules.
• Designing new photoresponsive hydrogels for drug delivery applications.
• Exploring the photochemistry of semiconductor nanoparticles for potential applications in quantum computing.
• Investigating the mechanisms of photochemical reactions in ionic liquids.
• Developing new photonic sensors for chemical and biological detection.
• Studying the photochemistry of transition metal complexes for potential applications in water splitting and hydrogen production.

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• ACS Publications

33 Critical Topics in Chemistry for 2020

• Apr 9, 2020
• 21 min read

Browse 33 of the most important, engaging topics in chemistry with Virtual Collections released by ACS Publications journals in Q4 2019 and Q1 2020.

ACS Publications regularly produces collections of the most important chemistry research topics. These Virtual Collections of the most important chemistry research topics bring together the most important ideas in the field in a variety of ways, including Special Issues and ACS Selects from across the portfolio journals. These collections reflect the most important chemistry research topics of current scientific interest and are designed for experienced investigators and educators alike.

Browse 33 of the most important, engaging topics in chemistry with Virtual Collections released by ACS Publications journals in Q4 2019 and Q1 2020:

Resources for Teaching Your Chemistry Class Online: A Free to Read Collection from the American Chemical Society & the ACS Division of Chemical Education

In support of the dedicated educators who are meeting the challenge of keeping their students’ chemistry education going, while schools are closed to slow the spread of the novel coronavirus (2019–nCoV), ACS Publications and the ACS Division of Chemical Education are sharing this collection of resources, including free to read articles from the Journal of Chemical Education.

Women at the Forefront of Chemistry

In this special collection, the first Virtual Issue for ACS Omega, we celebrate the contribution of women researchers who have published new advances from their groups in our journal. The year 2020 is special since it marks the 25th anniversary of The Beijing Platform for Action, the most advanced blueprint for achieving gender equality in the world. It also marks ten years since the establishment of UN Women, and the 20th anniversary of the UN Security Council resolution 1325 on women, peace, and security.

Overview of Research on the Fate and Behavior of Enveloped Viruses in the Environment

A large majority of studies on the environmental sources, fate, and transport of viruses have focused on non-enveloped viruses such as norovirus and enteroviruses. More recent high profile, global outbreaks of viral diseases have been caused by enveloped viruses including viruses from the Coronavirus family (SARS, MERS, COVID-19). Enveloped viruses feature a lipid membrane surrounding their protein capsid and genome. Lack of knowledge on the presence of infective enveloped viruses in human waste, the environmental fate and transport of enveloped viruses, best practices to disinfect surfaces and water, wash contaminated body parts, and treat wastewater and feces to removal enveloped viruses, has hampered outbreak response. Research into the environmental persistence and routes of transmission of SARS, MERS, and COVID-19 is further complicated by safety concerns of working with high-risk viruses. Limited direct research is therefore available on the environmental persistence of viruses in the Coronavirus family. The majority of research has been conducted on enveloped ‘surrogate’ viruses.

Computational Toxicology

Computational models have earned broad acceptance for assessing chemical toxicity during early stages of drug discovery or environmental safety assessment. Consequently some academic groups and many companies have developed such platforms for chemical toxicity prediction. This joint virtual issue from Journal of Chemical Information and Modeling and Chemical Research in Toxicology highlights recent developments in the area of computational toxicology; an important component of modern drug discovery and chemical safety assessment research. Both journals continue to be committed to publishing innovative and impactful papers in this research discipline.

JOC 2019 Featured Articles: Unique, Inspiring, and Exceptionally Well-Done Chemistry

Like in sports, from the professional level on down to the local youth level, the top-performing athletes for a season garner accolades by winning awards and being named to all-star teams. In other venues, such as music, television, and film, we have Grammys, Emmys, and Oscars. In science, we have the Nobel Prize and election to National Academies. Those are just a few ways we recognize achievement. The Journal of Organic Chemistry has its annual list of all-star award-winners as well: Featured Articles.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE), a degenerative brain disease, is the result of a slow spreading of Tau proteins throughout the brain in a pattern that is unique to CTE, as a result of repetitive hits to the head. As a result, CTE patients experience progressive memory issues, severe mood changes and erratic, often suicidal and/or violent, behavior. The prevalence of this condition is becoming increasingly well understood, and has been observed in a broad range of individuals including athletes in high-contact sports, military veterans, even victims of repeated domestic abuse. A key issue is that the disease can only currently be definitively diagnosed post-mortem by brain tissue analysis. As a result, ACS Chemical Neuroscience has actively solicited and published a number of articles seeking novel approaches for diagnostic assays and imaging techniques, therapeutic strategies, and new insights into fundamentals aspects of Tau aggregation as it relates to CTE. With this Virtual Issue, we highlight key papers on the topic, and encourage you to continue submitting your significant advances on all aspects of Tau, CTE, and other prion diseases to ACS Chemical Neuroscience .

Carbon Capture & Conversion

Climate change is a global concern, with the potential to severely impact the lives of people all around the world. Researchers from across the ACS community are working to mitigate these changes by developing technologies to capture CO2 to keep it out of the atmosphere, and then convert CO2 to useful chemical stocks. This virtual issue brings together articles from Accounts of Chemical Research, ACS Applied Materials and Interfaces, ACS Catalysis, Chemical Reviews, and Journal of the American Chemical Society on the topic of Carbon Capture and Conversion.

Super-Resolution Far-Field Optical Microscopy

This Virtual Issue highlights recent articles in The Journal of Physical Chemistry A/B/C, The Journal of Physical Chemistry Letters, ACS Nano, Analytical Chemistry, ACS Photonics, and Nano Letters that describe super‐resolution measurements using far‐field optical microscopes. Optical microscopy is a widely used tool for examining the structure of materials and investigating dynamics. In traditional optical microscopes, the spatial resolution is limited by diffraction to roughly the wavelength of light divided by 2 (several hundred nanometers in most cases). This limit can be overcome in different ways, with the first demonstrations utilizing near‐field optical effects. More recently, there has been a large amount of effort in adapting regular far‐field optical microscopes for super‐resolution imaging. Varieties of different approaches have been developed, and the importance of this field was recognized with the 2014 Nobel Prize to Betzig, Hell and Moerner. The focus of this Virtual Issue is on far-field measurements because these techniques are less complex, easier to implement and have a wider field‐of‐view than that of near‐field scanning optical microscopy measurements.

Remembering Dr. Richard P. Van Duyne

To celebrate and honor the life and work of Prof. Richard Van Duyne, ACS Publications have compiled a partial list of his publications. Van Duyne was an extraordinary chemist best known for his pioneering roles in nanoscale plasmonics and surface‐enhanced Raman scattering (SERS) but also well‐known for his mentorship and advocacy for chemists from traditionally underrepresented groups. Van Duyne passed away in July 2019, leaving a multitude of mentees, collaborators, and friends whose careers and science are better for having interacted with him. There are many exciting publications that could not fit within this virtual issue, so please consider this invitation to explore all of Van Duyne’s scientific contributions more deeply.

F. Javier Aoiz Festschrift

F. Javier Aoiz started his career as an experimentalist. This experience provided him with a profound understanding of experimental research in molecular reaction dynamics, and that understanding pervades many of his publications. This ranges from providing detailed modeling of experimental methods, simulations of experimental results, or developments of data analysis. The motivation of this work is clear: the correct interpretation of an experiment is only possible if the experiment is fully characterized, and it is precisely understood what the experiment can measure. Many of Javier’s publications reveal detailed simulation work, in which experiments and theory are compared as closely as possible on the same footing.

Celebrating Women in Organic Chemistry

Organic Chemistry is arguably the richest and most diverse field of science, covering an impressive array of topics with foundations in biology, chemistry, physics, and materials science that give rise to applications that touch on every aspect of our daily lives. But as with all areas of science and engineering, the diversity of the people who contribute to this science remains a work in progress.

Chemistry in Coronavirus Research: A Free to Read Collection from the American Chemical Society

In light of the current outbreak of a novel coronavirus (2019–nCoV), ACS Publications would like to share this Virtual Issue that features a collection of articles on coronavirus research. Chemistry has a key role to play in understanding everything from viral structure to pathogenesis, isolation of vaccines and therapies, as well as in the development of materials and techniques used by basic researchers, virologists and clinicians. This Virtual Issue aims to provide a brief overview of the important contributions of chemistry to understanding and controlling the spread of coronaviruses and includes articles from ACS Infectious Diseases, ACS Chemical Biology, Journal of Medicinal Chemistry, Biochemistry, Chemical Reviews, and ACS Applied Materials & Interfaces as well as the preprint server ChemRxiv. We hope the research contained in this Virtual Issue will provide you with important insight into challenges and approaches in virus research.

From Russia, With Chemistry

When speaking of Russian chemistry, the first thoughts for many people will be of Mendeleev, best known for his rendering of the Periodic Table. Mendeleev is but one Russian chemist, though; Russia has a rich tradition in the chemical sciences, although international political-ideological differences and language barriers over time have limited open communication of this science around the world. In recent years, however, these challenges have been evaporating and leading to an unprecedented global reach for chemistry.

Women Scientists at the Forefront of Energy Research

We celebrate the contribution of female energy researchers who have published new advances from their laboratories in ACS Energy Letters. In order to inspire other scientists working in the field, we asked them to comment on their inspiration to engage in energy research, discuss an “aha” moment in research, and/or provide advice to newcomers in the field. These personal stories, collected from early career researchers to well-established senior scientists, span the successful career paths they have taken to become leaders in the community. It is our hope that these personal reflections can motivate many young researchers to tackle challenges in clean energy. In this two-part series, we compile papers published by women.

Metal Complexes for Catalytic Polymerizations

The production of polymers worldwide exceeds 350 million tons/year, and polymerization catalysis is crucial in this gargantuan effort, not just for mediating reaction rates and product selectivity to deliver cost-effect manufacturing but also for controlling polymer properties such as molecular weight, crystallinity, rheology, and mechanical performance. As such, innovations in polymerization catalysis require understanding both inorganic chemistry and polymer macromolecular properties. To reflect on this interdisciplinary approach, Inorganic Chemistry and Macromolecules present this Virtual Issue, “Metal Complexes for Catalytic Polymerizations,” depicting a collaboration between these two leading ACS journals that publish research at the heart of this chemistry.

Chasing Plasmons in Flatland

Two-dimensional layered crystals, including graphene and transition metal dichalcogenides, represent an interesting avenue for studying light-matter interactions at the nanoscale in confined geometries. They offer several attractive properties, such as large exciton binding energies, strong excitonic resonances, and tunable bandgaps from the visible to the near-IR along with large spin−orbit coupling, direct bandgap transitions, and valley-selective responses.

Protein Engineering for Sensors

As masters of molecular recognition, proteins are key components in many molecular sensors, either as part of a sensor device or as a stand-alone sensor. The former include proteins involved in molecular recognition (antibodies, ligand-binding domains, DNA-binding proteins, enzymes) or in signal generation (reporter enzymes, fluorescent proteins, polymerases). Molecular recognition and signal generation are integrated into a single sensor protein in stand-alone sensors, rendering these sensors attractive as genetically encoded sensors for intracellular sensing and as sensor proteins for point-of-care diagnostics. Despite its importance, the role of protein engineering in sensor development remains sometimes underappreciated and many opportunities remain for protein engineering and synthetic biology to contribute to the sensor field. In this virtual issue, we have selected 27 recent articles from ACS Sensors, ACS Chemical Biology, ACS Synthetic Biology and Bioconjugate Chemistry that represent the most recent developments in the engineering of new proteins for sensing and together illustrate the importance of protein engineering to the field of sensors ***

Hai-Lung Dai Festschrift

Hai-Lung is a productive and creative experimental physical chemist, who has been a much-admired mentor for several generations of scientists, as well as a stimulating colleague and collaborator. This issue is a collection of papers from students and postdocs who have worked in Hai-Lung’s laboratory, as well as his colleagues and friends. As can be seen from the list of papers, the topics that are covered in this Virtual Special Issue are extremely broad, ranging from the high-resolution spectroscopy of small molecules, through to linear and nonlinear optical studies of biological systems, plasmonics, and surface science. This, of course, reflects Hai-Lung’s own broad interests in science. In addition to running a large and vigorous research group, Hai-Lung has also held a number of important administrative roles at the University of Pennsylvania and Temple University. In these roles, he has nurtured the careers of many scientists beyond those that have formally worked in his own group. Hai-Lung has also been a leader in advancing science and chemistry education in the city of Philadelphia, where he has spent the majority of his career and raised his family.

Recent Highlights on Interfaces from India

Getting to know the authors, reviewers, and readers from a broad range of institutions located around the world and at different stages in their career is one of the most exciting aspects of working with Langmuir. This global community is united in accumulating new knowledge on various facets of science where interface plays an important role. In this virtual issue, Langmuir is delighted to highlight the invaluable contributions of authors from India whose publications form a set of most widely read, and highly cited articles over the last three years.

Biomacromolecules for Emerging Biological and Medical Science and Technology

On the occasion of the 20th Anniversary of Biomacromolecules, we have also assembled a collection of 10 invited Perspectives from representative scientists in distinct research areas. The topics broadly cover development of biomacromolecules for advanced tissue engineering, bio-perspectives of shape-memory polymers, controlled synthesis and biomedical applications of biomacromolecules hybrid materials, polymeric vectors for non-viral nucleic acid delivery and gene editing, and advanced nanomedicines for cancer therapy. In the past 20 years, Biomacromolecules has become a flagship journal dedicated to serve the global biomacromolecules community and we hope the journal will continue to be a prime forum of choice for disseminating the most important findings in biomacromolecules research and development.

The Life and Times of Richard A. Andersen

Academic researchers are usually quick to recognize the accomplishments of their colleagues, heaping praise on them when they reach a milestone birthday or, sadly, when they pass away. A few seem to always rise above the accolades to a place of higher reverence. One of those is Chemistry Professor Richard A. Andersen of the University of California, Berkeley.

Leo Radom Festschrift

Professor Leo Radom was born in Shanghai in 1944. His family moved to Sydney, Australia, in 1947. Following his BSc in Chemistry at the University of Sydney, he obtained his Ph.D. in experimental physical organic chemistry in 1969 with Raymond Le Fèvre. Leo then turned to theory during a postdoctoral period with John Pople at Carnegie-Mellon University in Pittsburgh. He returned to Australia in 1972 to the Research School of Chemistry at the Australian National University and then moved to the University of Sydney in 2003, where he is now an Emeritus Professor of Chemistry. Leo’s main research interests concern the study of the structures and stabilities of molecules and the mechanisms of reactions in which they are involved, by the use of highly accurate computational quantum chemistry procedures. He has published over 500 papers, which have been cited over 39 000 times in the scientific literature.

The Waterloo Institute for Nanotechnology

The Waterloo Institute for Nanotechnology (WIN) is Canada’s largest nanotechnology institute and a world leader in nanoscience and nanotechnology that addresses the United Nations’ sustainable development goals. This Virtual Issue highlights research breakthroughs in energy harvesting and storage technology areas published by members of WIN in ACS Nano in the past decade.

Iron Redox Chemistry and Its Environmental Impact

Iron (Fe) is the most abundant redox-active element at the Earth’s surface. It occurs in diverse host rock lithologies, sediments, and soils as accessory oxide and oxyhydroxide minerals and nanoparticles that can dominate the reactive mineral/water interfacial area. From the field scale down to the nanoscale, this Virtual Special Issue seeks to highlight conceptual advances in understanding the interfacial redox chemistry of Fe and closely related metal oxide surfaces (e.g., Mn), so that reaction rates and the strength of chemical associations over time can ultimately be more accurately predicted. The issue features a critical review about the dissolution of Fe in Fe-rich minerals along with 20 research articles covering a broad spectrum of new geochemical process understanding in areas of (a) formation and phase transformations, (b) sorption processes, and (c) abiotic and biotic redox mechanisms at interfaces.

Structure Property Relationship in Crystalline Solids

Structural correlation with the properties of crystalline solids has witnessed remarkable growth in recent years. The complexities in the structure and its relationship with the molecular properties might need to reach the next level of understanding for a more efficient design of materials. Indeed, a thorough knowledge of X-ray crystallography is mandatory to understand the solid-state structure of crystalline materials and subsequently the molecular assembly for effective design of solids with tailored properties. To develop an effective material, primarily a robust perception about the directionality and strength of noncovalent interactions (comprising hydrogen bonding, π···π interactions, and halogen bonding) appears vital. To date, researchers have dedicated significant efforts to discover materials pertaining to a plethora of applications, but a faster progression could be achieved by the synergy between the design strategy of molecules and an adequate understanding of the intermolecular forces involved therein.

Astrochemistry: From the Chemical Laboratory to the Stars

This Virtual Issue combines recent publications from the Journal of Physical Chemistry A and ACS Earth and Space Chemistry to highlight new advances in the field of astrochemistry. The highly interdisciplinary field of astrochemistry incorporates research ranging over laboratory spectroscopic studies of astrophysical molecules, laboratory kinetics and dynamics studies of astrochemical processes, computational studies of astrophysical molecules, modeling of astrochemical processes, and observational studies of molecule-rich astronomical environments. The papers in this collection span this range of topics, offering a glimpse into a rich and interdisciplinary field that encompasses work from a variety of research areas in chemistry.

San Sebastian, a City of (Nano)Science and Technology

San Sebastian has recently become a city of science and technology, with a strong focus on nanoscience research, characterized by interdisciplinary approaches and the support of intense industrial activity in the region. The San Sebastian nanoscience community has contributed considerably to ACS Nano, with more than 100 publications during the past decade. This Virtual Issue of ACS Nano features the most impactful publications from San Sebastian nanoscience community.

Letters from India: A Perspective on Organic Chemistry

Crystal Growth of Organic Materials – CGOM13

This virtual issue features some selected papers taken from the 13th International Workshop on the Crystal Growth of Organic Materials (CGOM13) which was held in Seoul (South Korea) in August 2018. CGOM13 was organized by Professors Woo-Sik Kim and Jeong Won Kang from Kyung Hee University and Korea University, respectively, and attracted 175 attendees including 78 overseas delegates from 13 countries.

Lithium-Ion Batteries and Beyond: Celebrating the 2019 Nobel Prize in Chemistry

To commemorate the 2019 Nobel Prize in Chemistry awarded to John B. Goodenough, M. Stanley Whittingham, and Akira Yoshino for their pioneering contributions to Li-ion battery research, we are honoured to share a collection of reviews, perspectives, viewpoints, and research articles that Profs. Goodenough and Whittingham published in ACS journals. This virtual issue represents a small subset of their more recent articles (a challenge to narrow down when considering such prolific authors!) from the journals Accounts of Chemical Research, ACS Applied Energy Materials, ACS Applied Materials & Interfaces, ACS Catalysis, ACS Energy Letters, Chemical Reviews, Chemistry of Materials, Journal of the American Chemical Society, and The Journal of Physical Chemistry C. Through these articles, they explore the evolution of the Li-ion battery, state-of-the-art developments, opportunities and challenges in energy storage, as well as emerging areas such as the advancement of sodium-ion, inverse-aluminum, and solid-state batteries. We hope that you enjoy this collection in celebration of the pioneering achievements of Profs. Goodenough, Whittingham, and Yoshino.

Bioinspired Catalysis

Inspired by the wealth of chemistry that enzymes are able to perform in living organisms, chemists have looked up to nature in order to design more efficient and selective catalysts to enable challenging transformations. This virtual issue outlines some of the cutting-edge discoveries in the field touching on topics such as the emergence of homochirality, the development of asymmetric C–H activation processes as well as the design and repurposing of metalloenzymes among many others.

Machine-Learning Discoveries in Materials Science

Applications of machine learning, and machine learning-based models in materials chemistry, are a rapidly growing area of research. Machine learning enables the discovery of trends in chemical data, and provides guidance for new materials via fast screening of unexplored chemical white space. The next ground-breaking discovery of a high-efficiency thermoelectric or a room-temperature superconductor may happen thanks to insights from machine learning, and it is exciting to see a growing number of submissions to Chemistry of Materials that view machine learning as a helpful tool for materials discovery. We have loosely grouped the 22 papers in this virtual issue into two categories: machine learning to enable (i) predictions of materials properties, including band gap, thermal and ion conductivity, surface properties, and luminescence, and (ii) predictions of structure and experimental optimization. Of course, many of the papers tackle both aspects, and thus these divisions are a simply a loose classification to ‘guide the eye’. We hope that this virtual issue on machine learning applied to materials chemistry will inspire your own discoveries.

GPCRs – G Protein-Coupled Receptors

This Virtual Special Issue presents notable advances in our understanding of G Protein-Coupled Receptors (GPCRs) published in 2018 and 2019 in ACS Pharmacology & Translational Science. GPCRs are the largest class of cell surface receptor proteins and one of the major classes of drug targets. This collection, from many of the leading researchers in the field, explores the structure and function of GPCRs including the key concepts of biased signalling and allosteric modulation, the identification of new tools, and their application to advancing physiological understanding and disease intervention.

Three Pillars of Effective Research: Measurements, Analysis, and Dissemination

The availability of automated instruments and software has created a level playing field for performing scientific measurements for researchers around the globe. Individuals have the responsibility to ensure that all steps undertaken to build the three pillars of scientific research (collection, analysis and presentation of data) are verifiable. This Virtual Issue features articles from ACS Catalysis, ACS Energy Letters, ACS Nano, Chemistry of Materials, and the Journal of Physical Chemistry Letters that serve as valuable resources for both well-established and early career researchers as they seek to conduct and present their work with optimal accuracy and reliability.

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Collection  29 March 2022

2021 Top 25 Chemistry and Materials Sciences Articles

We are pleased to share with you the 25 most downloaded  Nature Communications  articles* in chemistry and materials sciences published in 2021. Featuring authors from around the world, these papers highlight valuable research from an international community.

Browse all Top 25 subject area collections  here .

*Data obtained from SN Insights (based on Digital Science's Dimensions) and normalised to account for articles published later in the year.

Research highlights

Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis

Grignard reagents have widespread utility in organic chemistry, but their preparation is limited by several drawbacks, such as the use of dry organic solvents and long reaction times. Here, the authors report a general mechanochemical synthesis of Grignard reagents in paste form in air, using a ball milling technique.

• Rina Takahashi

Programmable microbial ink for 3D printing of living materials produced from genetically engineered protein nanofibers

Living cells can precisely assemble to build 3D functional architectures. Here the authors produce an extrudable microbial ink entirely from the engineered cells, which can be further programmed to 3D print functional living materials.

• Anna M. Duraj-Thatte
• Avinash Manjula-Basavanna
• Neel S. Joshi

A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems

Lipid nanoparticle delivery of mRNA vaccines has become of particular importance, however, mRNA stability is a major concern. Here, the authors report on a study of lipid impurity mRNA interactions using reverse phase ion pair HPLC to identify reactions which render the mRNA untranslatable, reducing vaccine efficiency.

• Meredith Packer
• Dipendra Gyawali

Understanding Li-based battery materials via electrochemical impedance spectroscopy

Electrochemical impedance spectroscopy is a key technique for understanding Li-based battery processes. Here, the authors discuss the current state of the art, advantages and challenges of this technique, also giving an outlook for future developments.

• Miran Gaberšček

A general strategy for C(sp 3 )–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor

When carbon-based units are functionalized in photoredox catalysis, electrophilic coupling partners are often used, such that the polarities of the two fragments are appropriately matched. Here the authors show a generalized methodology to instead use nucleophilic coupling partners, which are cheaper and often simpler, via successive hydrogen atom transfer and oxidative radical-polar crossover.

• Isabelle Nathalie-Marie Leibler
• Makeda A. Tekle-Smith
• Abigail G. Doyle

Identifying molecules as biosignatures with assembly theory and mass spectrometry

The search for life in the universe is difficult due to issues with defining signatures of living systems. Here, the authors present an approach based on the molecular assembly number and tandem mass spectrometry that allows identification of molecules produced by biological systems, and use it to identify biosignatures from a range of samples, including ones from outer space.

• Stuart M. Marshall
• Cole Mathis
• Leroy Cronin

Tempering of cocoa butter and chocolate using minor lipidic components

In chocolate production, a complicated tempering process is used to guide the crystallization of cocoa butter towards its most desirable polymorph, which gives the chocolate proper melting behavior, gloss, and snap—hallmarks of good quality chocolate. Here, the authors find that simply adding a specific phospholipid also directs crystallization towards this polymorph, producing chocolate with comparable microstructure and properties to tempered chocolate.

• Saeed M. Ghazani
• Alejandro G. Marangoni

Production of high-energy Li-ion batteries comprising silicon-containing anodes and insertion-type cathodes

Large-scale manufacturing of high-energy Li-ion cells is of paramount importance for developing efficient rechargeable battery systems. Here, the authors report in-depth discussions and evaluations on the use of silicon-containing anodes together with insertion-based cathodes.

• Gebrekidan Gebresilassie Eshetu
• Egbert Figgemeier

Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life

Coacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RNA and lipids, enabling RNA to protect the droplet from dissolution by lipids.

• Muneyuki Matsuo
• Kensuke Kurihara

Nickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO 2

Electrochemistry is a promising approach to make existing chemical protocols milder, but many simple transformations of feedstocks are still out of reach. Here, the authors transform unactivated aryl and alkyl (pseudo)halides into carboxylic acids, via nickel catalysis and electricity, using atmospheric CO 2 as the carbon source.

• Guo-Quan Sun

Gene editing enables rapid engineering of complex antibiotic assembly lines

Engineering biosynthetic assembly lines is a powerful path to new natural products but is challenging with current methods. Here the authors use CRISPR-Cas9 to exchange subdomains within NRPS to alter substrate selectivity.

• Wei Li Thong
• Yingxin Zhang
• Jason Micklefield

Electrochemical ammonia synthesis via nitrate reduction on Fe single atom catalyst

Developing green and delocalized routes for ammonia synthesis is highly important but still very challenging. Here the authors report an efficient ammonia synthesis process via nitrate reduction to ammonia on Fe single atom catalyst.

• Mohammadreza Karamad
• Haotian Wang

Coordination environment dependent selectivity of single-site-Cu enriched crystalline porous catalysts in CO 2 reduction to CH 4

Crystalline porous catalysts with single Cu sites are dedicated to exploring the dependence of CO 2 electroreduction selectivity on the coordination environment of catalytic sites. The conductive MOF Cu-DBC with oxygen-coordinated Cu sites shows a high Faradaic efficiency ~80% of CO 2 -to-CH 4 .

• Long-Zhang Dong
• Ya-Qian Lan

6 nm super-resolution optical transmission and scattering spectroscopic imaging of carbon nanotubes using a nanometer-scale white light source

The authors present a super-resolution hyperspectral imaging technique using a nanoscale white light source generated by superfocusing light from a tungsten-halogen lamp. They achieve 6 nm resolution, measuring longitudinal and transverse optical electronic transitions in single-walled carbon nanotubes.

Electrochemical C–N bond activation for deaminative reductive coupling of Katritzky salts

Electrochemical transformations use electrons and electron holes instead of chemical oxidants and reductants as reagents. Here, the authors report an electrochemical reductive deaminative cross-coupling of Katrizky salts with various radical acceptors, including examples of fluoroalkenylation, alkynylation and thiolation.

• Xiangzhang Tao

Ultra-thin self-healing vitrimer coatings for durable hydrophobicity

By now a plethora of ultrathin hydrophobic coatings are available but their durability are not well developed. Here, the authors present a thin, durable and fluorine-free PDMS-based vitrimer coating that implements many desirable aspects like energy efficiency, durability and sustainability.

• Jingcheng Ma
• Laura E. Porath
• Christopher M. Evans

A saccharide-based binder for efficient polysulfide regulations in Li-S batteries

The long-term cycling of Li-S batteries depends on the polysulfides shuttling regulation. Here, the authors present a saccharide-based binder system to control the polysulfides migration and improve the cycle life of a Li-S pouch cell.

• Yingyi Huang
• Mahdokht Shaibani
• Mainak Majumder

Sustained enzymatic activity and flow in crowded protein droplets

Living cells can harvest environmental energy to drive chemical processes. Here the authors design a minimal artificial system that achieves steady states at similar metabolic densities to microorganisms.

• Andrea Testa
• Mirco Dindo
• Paola Laurino

Freezing of few nanometers water droplets

Ice nucleation in confined geometries is a ubiquitous phenomenon, but difficult to characterize. Here the authors investigate experimentally the freezing of water nanodroplets surrounded by octane in nanopores down to 2 nm, and demonstrate that the soft curved oil-water interface suppresses heterogeneous ice nucleation, which occurs at a lower temperature than homogenous bulk nucleation.

• Alireza Hakimian
• Mohammadjavad Mohebinia
• Hadi Ghasemi

Transition metal-doped Ni-rich layered cathode materials for durable Li-ion batteries

Long-term efficient cycling stability is of paramount importance for the development of high-energy Li-ion batteries. Here, the authors investigate the effect of transition metal dopants on the electrochemical, morphological, and structural properties of Ni-rich cathode active materials.

• H. Hohyun Sun
• Un-Hyuck Kim
• Yang-Kook Sun

Divergent functionalization of aldehydes photocatalyzed by neutral eosin Y with sulfone reagents

Acyl radicals represent a reactive species that allow for aldehyde subunits to be nucleophilic instead of their typical electrophilic behavior; however, these species are difficult to access in mild conditions. Here the authors show a method to generate acyl radicals using only an organic photocatalyst and light, and these species are shown as competent nucleophiles in a variety of couplings.

• Jianming Yan

Engineering single-atomic ruthenium catalytic sites on defective nickel-iron layered double hydroxide for overall water splitting

Rational design of single atom catalyst is critical for efficient sustainable energy conversion. Single-atomic-site ruthenium stabilized on defective nickel-iron layered double hydroxide nanosheets achieve superior HER and OER performance in alkaline media.

• Panlong Zhai
• Mingyue Xia
• Jungang Hou

Artificial intelligence-enhanced quantum chemical method with broad applicability

Artificial intelligence is combined with quantum mechanics to break the limitations of traditional methods and create a new general-purpose method for computational chemistry simulations with high accuracy, speed and transferability.

• Peikun Zheng
• Roman Zubatyuk
• Pavlo O. Dral

Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films

Green use of plant derived proteins in functional materials has been limited by inefficient methods to control micro and nanoscale structure. Here, the authors use nanoscale assembly of water-insoluble plant proteins to make meter scale films with comparable properties to conventional plastics.

• Ayaka Kamada
• Marc Rodriguez-Garcia
• Tuomas P. J. Knowles

Moving beyond bimetallic-alloy to single-atom dimer atomic-interface for all-pH hydrogen evolution

While single, dispersed atoms enable efficient atomic utilization, controllably preparing single-atom dimers remains challenging. Here, authors prepare nickel-cobalt single-atom dimers as high-performance pH-universal H 2 evolution electrocatalysts.

• Ashwani Kumar
• Viet Q. Bui
• Hyoyoung Lee

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Chemistry - research topics.

The following Research Topics are led by experts in their field and contribute to the scientific understanding of chemistry. These Research topics are published in the peer-reviewed journal Frontiers in Chemistry , as open access articles .

Polymer Functional Composite

This Research Topic provides a good platform for communication and better reflects the current development status and future trends of polymer functional composite materials.

Exploring Novel Approaches to Small Molecule Kinase Inhibitors in Cancer Treatment

This Research Topic focuses on novel, small molecules targeting protein kinases in cancer treatment.

Nanochemistry in Biomaterials for Regenerative Medicine and Controlled Drug Release

Research Topic aims to highlight the importance of integrating nanochemistry principles to achieve precise control over material properties and drug interactions, resulting in improved therapeutic outcomes.

Diversifying Chemical Synthesis with Cascade Catalysis

The goal of this Research Topic is to provide a comprehensive overview and stimulate increased efforts in cascade catalysis, combining electro-, photo-, thermo-, and biocatalysis to create a chemical synthesis library and innovate synthetic pathways...

Photosensitizers: Synthesis and Biomedical Applications

This Research Topic encompasses the design, synthesis, and characterization of photosensitizing molecules and their biophotonics applications.

Sustainable Hydrogen Production and Utilization

This Research Topic aims to collect the latest technological advancements in the hydrogen production and utilization to provide cost-effective CO2 mitigation and low-cost energy.

Functional Nanomaterials for the Therapeutic Regulation of Tissue Redox Microenvironment- Volume II

In this Research Topic the aim is to cover the latest research on functional nanoparticles with unique capabilities for redox-related disease therapy.

Theory and Simulations of Liquid Electrolytes on Charged Interfaces and Under Nanoconfinement: Thermodynamic Equilibrium and Beyond

This Research Topic aims to demonstrate the practical applications of computational methods and algorithms, including molecular dynamics simulations, classical density functional theory (DFT), mean-field theory, machine learning, & artificial intelligence.

Sustainable Design and Fabrication of Nanomaterials and Micro-Devices

This research topic seeks original and innovative contributions to solve the problems of sustainable design, preparation and use of energy, materials and devices.

Lignin-based Micro- and Nano-entities: Functionalities and Applications

This Research Topic aims at providing state-of-the-art knowledge, technologies and highlight advances on lignin chemistry, behavior and performance at nanoscale.

Frontiers in Chemistry: Rising Stars in China

This collection showcases the high-quality work of Chinese recognized researchers in the early stages of their independent careers.

Quinoline as Lead Structures for the Development of Leishmanicidal Agents

This Research Topic seeks manuscripts dealing with novel approaches of identification of key pharmacophores for the design and development of new leishmanicidal agents based-on quinoline structure, either for models of Cutaneous or Visceral Leishmaniasis.

Design of Extended Networks for Tuning Functionality of Materials

The goal of this Research Topic is to cover promising, recent, and novel research trends in the design of extended networks for tuning functionality of materials.

Renewable Chemistry

This Research Topic will address the growing interest in and increasing need for renewable chemistry – both chemical reactions and processes that are based on renewable resources, and on products made from such resources.

Recent Applications of Polymers in Solar Cells

Background: Organic photovoltaics has drawn immense attraction in recent years due to advancements in development of new materials.

Unveiling the Significance of tert -Butoxides in Transition Metal-Free Cross-Coupling Reactions

• Vipin Kumar
• Suman Majee
• Devalina Ray

Research Progress of Deep-Red to Near-Infrared Electroluminescent Materials Based on Organic Cyclometallated Platinum(II) Complexes

• Cheng Zhang
• Yuanyuan Fang
• Wenjing Xiong

Recent Focuses in the Syntheses and Applications of Magnetic Metal–Organic Frameworks

• Yosra Mostafapour Kandelous
• Mohammad Nikpassand
• Leila Zare Fekri

A Review on Recent Development of Phenothiazine-Based Chromogenic and Fluorogenic Sensors for the Detection of Cations, Anions, and Neutral Analytes

• Mohan Ilakiyalakshmi
• Kumudhavalli Dhanasekaran
• Ayyakannu Arumugam Napoleon

Emerging Nanomaterials as Versatile Nanozymes: A New Dimension in Biomedical Research

• Denno Mathew
• Anitha Varghese

The Hamilton Receptor in Supramolecular Polymer Sciences

• Shafieq Ahmad Wagay

Review on Synthesis of 2-(2-Hydroxyaryl) Benzothiazoles (HBT) for Excited-State Intra-molecular Proton Transfer (ESIPT)-Based Detection of Ions and Biomolecules

• Amandeep Kaur
• R. P. Chaudhary

Advances in Black Phosphorus Quantum Dots for Cancer Research: Synthesis, Characterization, and Applications

• Elham Einafshar
• Ahmad Ghorbani

Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously

• Kevin R. Venrooij
• Lucienne de Bondt
• Kimberly M. Bonger

The State-of-the-Art Overview to Application of Deep Learning in Accurate Protein Design and Structure Prediction

• Saber Saharkhiz
• Mehrnaz Mostafavi
• Reza Akhavan-Sigari

Significance of Chalcone Scaffolds in Medicinal Chemistry

• Rishav Mazumder
• Rajat Ghosh

What Should be Considered While Designing Hole-Transporting Material for Perovskite Solar Cells? A Special Attention to Thiophene-Based Hole-Transporting Materials

• Palani Purushothaman
• Subramanian Karpagam

Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview

• Iqra Kalsoom
• Kiran Shehzadi
• Ming-jia Yu

Properties, Synthesis and Emerging Applications of Graphdiyne: A Journey Through Recent Advancements

• H. V. Nidhi
• Vinayaka S. Koppad

Indole as a Versatile Building Block in Cycloaddition Reactions: Synthesis of Diverse Heterocyclic Frameworks

• Biswajita Baruah
• Choitanya Dev Pegu
• Mohit L. Deb

Computational Organic Chemistry: The Frontier for Understanding and Designing Bioorthogonal Cycloadditions

• Dennis Svatunek

Coumarin—Synthetic Methodologies, Pharmacology, and Application as Natural Fluorophore

• Deepshikha Gupta
• Eksha Guliani
• Kiran Bajaj

Advances in the Synthesis of Bioorthogonal Reagents: s -Tetrazines, 1,2,4-Triazines, Cyclooctynes, Heterocycloheptynes, and trans -Cyclooctenes

• Yinzhi Fang
• Ashlyn S. Hillman
• Joseph M. Fox

Water-Soluble Small Organic Fluorophores for Oncological Theragnostic Applications: Progress and Development

• Ashanul Haque
• Khalaf M. Alenezi
• Wai-Yeung Wong

Pushing Boundaries: What’s Next in Metal-Free C–H Functionalization for Sulfenylation?

• Sandhya Chahal
• Jayant Sindhu

Reaction Pattern and Mechanistic Aspects of Iodine and Iodine-Based Reagents in Selenylation of Aliphatic, Aromatic, and (Hetero)Cyclic Systems

• Pankaj Kumar
• Aman Bhalla

Research Progress in Structure Synthesis, Properties, and Applications of Small-Molecule Silicone Surfactants

• Wenhui Zhao
• Yuqiao Cheng

Recent Advances in the Application of P(III)-Nucleophiles to Create New P−C Bonds through Michaelis–Arbuzov-Type Rearrangement

• Biquan Xiong
• Minjing Yuan
• Ke-Wen Tang

Chemical Aspects of Halide Perovskite Nanocrystals

• Mrinmoy Roy
• Milan Sykora

Unlocking Diversity: From Simple to Cutting-Edge Synthetic Methodologies of Bis(indolyl)methanes

• Pankaj Teli
• Shivani Soni
• Shikha Agarwal

Bioorthogonal Reactions in Bioimaging

• Eszter Kozma

Pt(IV) Complexes in the Search for Novel Platinum Prodrugs with Promising Activity

• Sainath Aher

Recent Progress in Phenoxazine-Based Thermally Activated Delayed Fluorescent Compounds and Their Full-Color Organic Light-Emitting Diodes

• Houda Al-Sharji
• Rashid Ilmi
• Muhammad S. Khan

Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

• Vipin K. Maikhuri
• Divya Mathur
• Brajendra K. Singh

Palladium N -Heterocyclic Carbene-Catalyzed Aminations: An Outline

• S. B. Umabharathi
• Mohan Neetha
• Gopinathan Anilkumar

Bioorthogonal Chemistry in Cellular Organelles

• Veronika Šlachtová
• Marek Chovanec
• Milan Vrabel

Photo-activatable Reagents for Bioorthogonal Ligation Reactions

• Heyang Zhang

Recent Advances in Bioorthogonal Ligation and Bioconjugation

• Florian M. Zielke
• Floris P. J. T. Rutjes

Progress of Metal Nanomaterial Controllable Preparation by Photoreduction

• Haifeng Han

Recent Advances in Palladium-Catalyzed [4 +  n ] Cycloaddition of Lactones, Benzoxazinanones, Allylic Carbonates, and Vinyloxetanes

• Mengyan Guo
• Panke Zhang

The Renaissance of Ferrocene-Based Electrocatalysts: Properties, Synthesis Strategies, and Applications

Principles of Photocatalysts and Their Different Applications: A Review

• Mohamed A. Hassaan
• Mohamed A. El-Nemr
• Ahmed El Nemr

Construction of 1,4-Dihydropyridines: The Evolution of C4 Source

• Yongchao Wang

C–H Bond Functionalization of N -Heteroarenes Mediated by Selectfluor

• Angel H. Romero

Functionalization of BODIPY Dyes with Additional C–N Double Bonds and Their Applications

• Huriye Ilhan
• Yusuf Cakmak

Recent Advances in MXene Quantum Dots: A Platform with Unique Properties for General-Purpose Functional Materials with Novel Biomedical Applications

• Nafiseh Einafshar
• Majid Khazaei

The Novel Organic Emitters for High-Performance Narrow-Band Deep Blue OLEDs

Recent Progress on Nitrogen-Rich Energetic Materials Based on Tetrazole Skeleton

Performance Regulation of Single-Atom Catalyst by Modulating the Microenvironment of Metal Sites

• Yanyan Zhao

Recent Progress in NiH-Catalyzed Linear or Branch Hydrofunctionalization of Terminal or Internal Alkenes

• Huimin Yang

Structure-Based Drug Design of RdRp Inhibitors against SARS-CoV-2

• Afsheen Saba
• Jianhua Liang

Photothermal Catalytic CO 2 Conversion: Beyond Catalysis and Photocatalysis

• Fernando Fresno
• Ana Iglesias-Juez
• Juan M. Coronado

The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles

• Carme Masdeu
• Jesús M. de los Santos
• Concepción Alonso

Multicomponent Reactions Using C , N -Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles

• Tasneem Parvin

Laser-Induced Transfer of Functional Materials

• Connie Kong Wai Lee
• Mitch Guijun Li

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