analytical biochemistry research centre

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PhD (Analytical Biochemistry) - Analytical Biochemistry Research Centre

Opportunities are available to suitably qualified graduates to carry out research in analytical biochemistry which involves different fields of study, such as food biochemistry, environmental biochemistry, proteomics, genomics, lipidomics, glycomics, metabolomics, environmental toxicology, forensic toxicology and biochemical analysis. Transdisciplinary research is encouraged within the centre and with other schools within the university. There are also opportunities to be involved in research projects which are carried out in collaboration with other universities, institutions, industry and community in Malaysia, as well as abroad.

The Analytical Biochemistry Research Centre offers the degrees of MSc and PhD by research in the following fields of specialization:

Expertises available in research centre are as follows:  ABrC Organizational Chart

Applicants should possess one of the following:

A. Master's degree in biochemistry, chemistry, biology, biotechnology, biomedical or other related fields

• A Master's degree in research mode; or
• A Master’s degree with CGPA 3.00/4; or
• A Master’s degree with CGPA 2.50-2.99/4 with additional requirements; or

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(Applicable for International Applicants Only)

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• A minimum of Band 107 for CIEP Level (ELS); or
• A minimum of Band 3.5 for Malaysian University English Test (MUET)

Exemption is given to candidate if:

• English is the candidate’s mother tongue or National Language; or
• Candidate graduated from an Institution of Higher Learning in which the medium of instruction at Bachelor and/or Master degree level is English (statement of proof required)
• Full-time: Min 4 semesters / Max 10 semesters
• Part-time: Min 6 semesters / Max 15 semesters

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Analytical biochemistry articles within Nature Chemistry

Article | 05 June 2023

A high-dimensional microfluidic approach for selection of aptamers with programmable binding affinities

Generating aptamers for use as affinity reagents in analytical applications is important, but SELEX, the standard method for aptamer generation, is unable to select for pre-defined binding affinities. Now, by combining efficient particle display, high-performance microfluidic sorting and high-content bioinformatics, the method ‘Pro-SELEX’ can afford the quantitative generation of aptamers with programmable binding affinities.

• Dingran Chang
• , Zongjie Wang
•  &  Shana O. Kelley

News & Views | 30 April 2021

Signal transduction with a swing

The continuous monitoring of proteins is a current challenge in medical diagnostics. A new electrochemical approach aiming to address this has been described. The method uses antibodies as a recognition element to achieve the real-time measurement of proteins in saliva in the mouth.

• Kevin J. Cash
•  &  Kevin W. Plaxco

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Detection of Intermolecular Interactions Based on Surface Plasmon Resonance Registration

Affiliation.

• 1 Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071, Russia. [email protected].
• PMID: 26878582
• DOI: 10.1134/S0006297915130131

Methods for registration of intermolecular interactions based on the phenomenon of surface plasmon resonance (SPR) have become one of the most efficient tools to solve fundamental and applied problems of analytical biochemistry. Nevertheless, capabilities of these methods are often insufficient to detect low concentrations of analytes or to screen large numbers of objects. That is why considerable efforts are directed at enhancing the sensitivity and efficiency of SPR-based measurements. This review describes the basic principles of the detection of intermolecular interactions using this method, provides a comparison of various types of SPR detectors, and classifies modern approaches to enhance sensitivity and efficiency of measurements.

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• Surface plasmon resonance biosensors incorporating gold nanoparticles. Bedford EE, Spadavecchia J, Pradier CM, Gu FX. Bedford EE, et al. Macromol Biosci. 2012 Jun;12(6):724-39. doi: 10.1002/mabi.201100435. Epub 2012 Mar 13. Macromol Biosci. 2012. PMID: 22416018 Review.
• A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes. Chien FC, Chen SJ. Chien FC, et al. Biosens Bioelectron. 2004 Oct 15;20(3):633-42. doi: 10.1016/j.bios.2004.03.014. Biosens Bioelectron. 2004. PMID: 15494249
• Bioanalytical approaches for the detection of single nucleotide polymorphisms by Surface Plasmon Resonance biosensors. Ermini ML, Mariani S, Scarano S, Minunni M. Ermini ML, et al. Biosens Bioelectron. 2014 Nov 15;61:28-37. doi: 10.1016/j.bios.2014.04.052. Epub 2014 May 5. Biosens Bioelectron. 2014. PMID: 24841091 Review.
• Surface plasmon resonance biosensing. Piliarik M, Vaisocherová H, Homola J. Piliarik M, et al. Methods Mol Biol. 2009;503:65-88. doi: 10.1007/978-1-60327-567-5_5. Methods Mol Biol. 2009. PMID: 19151937 Review.
• Near infrared surface plasmon resonance phase imaging and nanoparticle-enhanced surface plasmon resonance phase imaging for ultrasensitive protein and DNA biosensing with oligonucleotide and aptamer microarrays. Zhou WJ, Halpern AR, Seefeld TH, Corn RM. Zhou WJ, et al. Anal Chem. 2012 Jan 3;84(1):440-5. doi: 10.1021/ac202863k. Epub 2011 Dec 15. Anal Chem. 2012. PMID: 22126812
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Analytical Biochemistry Research Centre (ABrC)  |  Pusat Penyelidikan Biokimia Analisis

Postgraduate Studies & Training

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Handbook of Postgraduate Studies and other registration activities could be achieved via  https://ips.usm.my/index.php/download  

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PUSAT PENYELIDIKAN BIOKIMIA ANALISIS (ABrC) Analytical Biochemistry Research Centre (ABrC) Inkubator Inovasi Universiti (I 2 U), SAINS@USM,  Universiti Sains Malaysia, 11900 Bayan Lepas, Penang, Malaysia

 Tel:+6(04)-653 6828  |  Fax:+6(04)-653 4688 |  Email :  [email protected]